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Thiophene-3-ethanol

Product Name
Thiophene-3-ethanol
CAS No.
13781-67-4
Chemical Name
Thiophene-3-ethanol
Synonyms
2-(thiophen-3-yl)ethan-1-ol;3-THIOPHENEETHANOL;2-(thiophen-3-yl)ethanol;2-(3-ThienyL;THIOPHENE-3-ETHANOL;Thiophen-3-ylethanol;2-(3-THIENYL)ETHANOL;3-Thiopheneethanol 99%;Clopidogrel Impurity 51;3-THIOPHENEETHANOL 98+%
CBNumber
CB0492744
Molecular Formula
C6H8OS
Formula Weight
128.19
MOL File
13781-67-4.mol
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Thiophene-3-ethanol Property

Boiling point:
110-111 °C14 mm Hg(lit.)
Density 
1.144 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.552(lit.)
Flash point:
199 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
14.92±0.10(Predicted)
form 
Liquid
color 
Clear colorless to yellow-brown
Specific Gravity
1.144
Water Solubility 
Sparingly soluble in water(0.059 g/L at 25°C).
BRN 
107080
InChIKey
YYPNNBPPDFTQFX-UHFFFAOYSA-N
LogP
1.07
CAS DataBase Reference
13781-67-4(CAS DataBase Reference)
NIST Chemistry Reference
3-Thiopheneethanol(13781-67-4)
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Safety

Safety Statements 
23-24/25
WGK Germany 
3
F 
10
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
228796
Product name
3-Thiopheneethanol
Purity
99%
Packaging
5g
Price
$83.6
Updated
2025/07/31
Sigma-Aldrich
Product number
228796
Product name
3-Thiopheneethanol
Purity
99%
Packaging
25g
Price
$379.35
Updated
2025/07/31
TCI Chemical
Product number
T1475
Product name
3-Thiopheneethanol
Purity
>97.0%(GC)
Packaging
5g
Price
$83
Updated
2025/07/31
TCI Chemical
Product number
T1475
Product name
3-Thiopheneethanol
Purity
>97.0%(GC)
Packaging
25g
Price
$332
Updated
2025/07/31
TRC
Product number
T344865
Product name
3-Thiopheneethanol
Packaging
1g
Price
$55
Updated
2021/12/16
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Thiophene-3-ethanol Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellowish-brown liquid

Uses

3-Thiopheneethanol is used as a reagent in the synthesis of pH-responsive near-IR emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery. 3-Thiopheneethanol is also used as a reagent in the preparation of potent respiratory syncytial virus RNA polymerase inhibitors.

Uses

3-Thiopheneethanol [3-(2-hydroxyethyl)thiophene] was used in the synthesis of various ether and ester derivatives such as 3-(2-(benzyloxy)ethyl)thiophene, 3-[2-((triphenylmethyl)oxy)ethyl]thiophene, 3-[2-((trimethylsilyl)oxy)ethyl]thiophene, 3-[2-((dimethyl-tert-butylsilyl)oxy)ethyl]thiophene, 3-(2-acetoxyethyl)thiophene and 3-(2-(benzoyloxy)ethyl)thiophene.

Synthesis

6964-21-2

13781-67-4

Step 2: Synthesis of 2-(thiophen-3-yl)ethanol 1. to LiAlH4 (4.56 g, 0.12 mol) was added tetrahydrofuran (200 mL) at 0 °C and the mixture was stirred. 2. Slowly add THF solution of 2-(thiophen-3-yl)acetic acid (14.2 g, 0.1 mol dissolved in 100 mL of THF) dropwise to the above mixture, keeping the temperature at 0 °C. 3. after the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 2 hours. 4. EtOAc (200 mL) was slowly added to the reaction mixture followed by water (5 mL) to quench the reaction. 5. The resulting suspension was filtered through diatomaceous earth and the filtrate was dried with anhydrous sodium sulfate. 6. The dried filtrate was concentrated to dryness to give 2-(thiophen-3-yl)ethanol (12.44 g, yield: 99%). 7. The product was characterized by 1H NMR (MeOD, 400 MHz): δ 5.92-5.87 (m, 1H), 5.69-5.66 (m, 1H), 5.57 (s, 1H), 2.90 (d, J=14.0 Hz, 1H), 2.38 (d, J=14 Hz, 1H), 1.55-1.42 (m, 2H).

References

[1] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 148
[2] Synthesis, 2005, # 2, p. 267 - 271
[3] Synthesis (Germany), 2015, vol. 47, # 24, p. 3972 - 3982
[4] Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 256, p. 439 - 448
[5] Organic Process Research and Development, 2015, vol. 19, # 11, p. 1568 - 1575

Thiophene-3-ethanol Preparation Products And Raw materials

Raw materials

Nitrogen Tetrahydrofuran 3-Bromothiophene Lithium Aluminum Hydride n-Butyllithium Methyl chloroacetate

Preparation Products

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View Lastest Price from Thiophene-3-ethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Thiophene-3-ethanol 13781-67-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Henan Aochuang Chemical Co.,Ltd.
Product
Thiophene-3-ethanol 13781-67-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
R&D Scientific Inc.
Product
2-(Thiophen-3-yl)ethanol 13781-67-4
Price
US $320.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-02-19

13781-67-4, Thiophene-3-ethanolRelated Search:

Thiophene Ethyl acetate Thianaphthene 2-(METHYLSULFONYL)ETHANOL Ethanol Cephalothin sodium Thifensulfuron methyl 2-Thiophenecarboxaldehyde Tetrahydrothiophene 2-Thiazolecarboximidamide 2-Thiophenecarboxylic acid 2,5-Thiophenedicarboxylic acid Tioxolone 2,3-THIOPHENEDICARBOXALDEHYDE THIOPHENE-2-CARBOXALDOXIME 4-(2-THIAZOLYLAZO)RESORCINOL THIOPHENE-2-THIOCARBOXAMIDE N'-HYDROXY-2-THIOPHENECARBOXIMIDAMIDE

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  • 3-THIOPHENEETHANOL
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