ChemicalBook > CAS DataBase List > 3-Amino-4-chlorophenol
3-Amino-4-chlorophenol
- Product Name
- 3-Amino-4-chlorophenol
- CAS No.
- 16026-77-0
- Chemical Name
- 3-Amino-4-chlorophenol
- Synonyms
- 3-Amino-4-chlorophenol;4-chloro-3-amino phenol;Phenol, 3-amino-4-chloro-;3-AMINO-4-CHLOROPHENOL 97;3-Amino-4-chlorophenol 97%;3-
AMino- 4- chlorophenol - CBNumber
- CB0499798
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 16026-77-0.mol
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3-Amino-4-chlorophenol Property
- Melting point:
- 151-154 °C (lit.)
- Boiling point:
- 282.8±20.0 °C(Predicted)
- Density
- 1.406±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Powder
- pka
- 9.57±0.18(Predicted)
- color
- Pale orange to brown
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 16026-77-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 552488
- Product name
- 3-Amino-4-chlorophenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $73.3
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 552488
- Product name
- 3-Amino-4-chlorophenol
- Purity
- 97%
- Packaging
- 5g
- Price
- $184
- Updated
- 2023/06/20
TRC
- Product number
- A617735
- Product name
- 3-Amino-4-chlorophenol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
AK Scientific
- Product number
- J98867
- Product name
- 3-Amino-4-chlorophenol
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0021112
- Product name
- 3-AMINO-4-CHLOROPHENOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $349.65
- Updated
- 2021/12/16
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3-Amino-4-chlorophenol Chemical Properties,Usage,Production
Uses
3-Amino-4-chlorophenol may be used in the synthesis of hydroxymethyl rhodamines (HMRs).
General Description
3-Amino-4-chlorophenol is formed as a product from the photochemical decomposition of 2,5-dichloroaniline.
Synthesis
610-78-6
16026-77-0
Step 1. Reduction reaction: 4-chloro-3-nitrophenol (6.0 g, 34.6 mmol) and acetic acid (60 mL) were added to a 100-mL round-bottom flask equipped with a magnetic stir bar. Iron powder (325 mesh, 19.31 g, 346 mmol) was then added and the reaction mixture was heated with stirring at 100 °C for 30 min. After completion of the reaction, the mixture was cooled to room temperature and diluted with deionized water (40 mL). Step 2. Post-treatment: The diluted mixture was filtered through a diatomaceous earth pad and washed thoroughly with deionized water. The filtrate was extracted with ethyl acetate and the organic phases were combined and concentrated under reduced pressure. Step 3. Purification: Heptane (~100 mL) was added to the concentrated residue, followed by evaporation under reduced pressure to remove residual acetic acid and water, and the process was repeated. The final residue was dissolved in acetonitrile and concentrated again under reduced pressure. The resulting solid was suspended in heptane and concentrated under reduced pressure to afford 3-amino-4-chlorophenol (4.38 g, 88% yield) as a lavender to amber solid. The mass spectrum (ESI, cation mode) showed m/z 144 [M + 1].
References
[1] Journal of Organic Chemistry, 2013, vol. 78, # 9, p. 4530 - 4542
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 21, p. 3454 - 3457
[3] Patent: WO2015/74064, 2015, A2. Location in patent: Paragraph 0227
[4] Journal of the Brazilian Chemical Society, 2016, vol. 27, # 2, p. 372 - 381
3-Amino-4-chlorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-4-chlorophenol manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-Amino-4-chlorophenol 16026-77-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
Career Henan Chemical Co
- Product
- 3-Amino-4-chlorophenol 16026-77-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02
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