BocNH-PEG5-acid

ChemicalBook > CAS DataBase List > BocNH-PEG5-acid

Product Name: BocNH-PEG5-acid
CAS No.: 890152-41-7
Chemical Name: BocNH-PEG5-acid
Synonyms: BocNH-PEG5-acid;BocNH-P5-CH2CO2H;NHBoc-PEG5-CH2COOH;T-boc-n-amido-peg5-ch2co2h;t-boc-N-amido-PEG5-acetic acid;17-(Boc-amino)-3,6,9,12,15-pentaoxaheptadecan-1-oic Acid;2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid;17-{[(tert-butoxy)carbonyl]amino}-3,6,9,12,15-pentaoxaheptadecanoic acid;5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester;BocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester
CBNumber: CB05430550
Molecular Formula: C17H33NO9
Formula Weight: 395.45
MOL File: 890152-41-7.mol

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BocNH-PEG5-acid Property

Boiling point:: 526.2±50.0 °C(Predicted)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO : 100 mg/mL (252.88 mM; Need ultrasonic)
pka: 3.39±0.10(Predicted)
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 902683
Product name: BocNH-PEG5-acid
Packaging: 250MG
Price: $301
Updated: 2024/03/01

Sigma-Aldrich

Product number: 902683
Product name: BocNH-PEG5-acid
Packaging: 1G
Price: $925
Updated: 2024/03/01

Chemenu

Product number: CM327825
Product name: 2-[2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]aceticacid
Purity: 95%+
Packaging: 5g
Price: $1562
Updated: 2021/12/16

Acrotein

Product number: B-0896
Product name: BocNH-PEG5-CH2COOH
Purity: 97%
Packaging: 0.5g
Price: $302.5
Updated: 2021/12/16

Acrotein

Product number: B-0896
Product name: BocNH-PEG5-CH2COOH
Purity: 97%
Packaging: 1g
Price: $458.33
Updated: 2021/12/16

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BocNH-PEG5-acid Chemical Properties,Usage,Production

Description

t-Boc-N-amido-PEG5-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

reaction suitability

reaction type: Pegylations
reagent type: cross-linking reagent

BocNH-PEG5-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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BocNH-PEG5-acid Suppliers

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890152-41-7, BocNH-PEG5-acidRelated Search:

Biotin-PEG36-PFP ester N-(Amino-PEG3)-N-bis(PEG4-Boc) Biotin-PEG6-t-butyl ester FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID 2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHYL BROMIDE t-Boc-Aminooxy-PEG2-CH2CO2H N-Boc-PEG4-bromide N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Mal-amido-PEG7-acid Fmoc-NH-PEG12-CH2COOH

BocNH-PEG5-acid

5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester

t-boc-N-amido-PEG5-acetic acid

BocNH-P5-CH2CO2H

T-boc-n-amido-peg5-ch2co2h

NHBoc-PEG5-CH2COOH

BocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester

17-(Boc-amino)-3,6,9,12,15-pentaoxaheptadecan-1-oic Acid

2-[2-[2-[2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

17-{[(tert-butoxy)carbonyl]amino}-3,6,9,12,15-pentaoxaheptadecanoic acid

2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid

890152-41-7

C17H33NO9

peg