BocNH-PEG5-acid
- Product Name
- BocNH-PEG5-acid
- CAS No.
- 890152-41-7
- Chemical Name
- BocNH-PEG5-acid
- Synonyms
- BocNH-PEG5-acid;BocNH-P5-CH2CO2H;NHBoc-PEG5-CH2COOH;T-boc-n-amido-peg5-ch2co2h;t-boc-N-amido-PEG5-acetic acid;17-(Boc-amino)-3,6,9,12,15-pentaoxaheptadecan-1-oic Acid;17-{[(tert-butoxy)carbonyl]amino}-3,6,9,12,15-pentaoxaheptadecanoic acid;5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester;BocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester;2-[2-[2-[2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
- CBNumber
- CB05430550
- Molecular Formula
- C17H33NO9
- Formula Weight
- 395.45
- MOL File
- 890152-41-7.mol
BocNH-PEG5-acid Property
- Boiling point:
- 526.2±50.0 °C(Predicted)
- Density
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO : 100 mg/mL (252.88 mM; Need ultrasonic)
- pka
- 3.39±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 902683
- Product name
- BocNH-PEG5-acid
- Packaging
- 250MG
- Price
- $301
- Updated
- 2024/03/01
- Product number
- 902683
- Product name
- BocNH-PEG5-acid
- Packaging
- 1G
- Price
- $925
- Updated
- 2024/03/01
- Product number
- CM327825
- Product name
- 2-[2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]aceticacid
- Purity
- 95%+
- Packaging
- 5g
- Price
- $1562
- Updated
- 2021/12/16
- Product number
- B-0896
- Product name
- BocNH-PEG5-CH2COOH
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $302.5
- Updated
- 2021/12/16
- Product number
- B-0896
- Product name
- BocNH-PEG5-CH2COOH
- Purity
- 97%
- Packaging
- 1g
- Price
- $458.33
- Updated
- 2021/12/16
BocNH-PEG5-acid Chemical Properties,Usage,Production
Description
t-Boc-N-amido-PEG5-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.