Azido-PEG7-COOtBu
- Product Name
- Azido-PEG7-COOtBu
- CAS No.
- 2596867-40-0
- Chemical Name
- Azido-PEG7-COOtBu
- Synonyms
- N3-PEG7-COOtBu;Azido-PEG7-COOtBu;Azido-PEG7-tBu Ester;N3-PEG7-CH2CH2COOtBu;tert-butyl 1-azido-3,6,9,12,15,18,21-heptaoxatetracosan-24-oate;4,7,10,13,16,19,22-Heptaoxatetracosanoic acid, 24-azido-, 1,1-dimethylethyl ester
- CBNumber
- CB05478194
- Formula Weight
- 479.57
- MOL File
- 2596867-40-0.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Azido-PEG7-COOtBu Chemical Properties,Usage,Production
Uses
Azido-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG7-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
Azido-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Azido-PEG7-COOtBu Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG7-COOtBu manufacturers
- Product
- tert-butyl 1-azido-3,6,9,12,15,18,21-heptaoxatetracosan-24-oate 2596867-40-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12
- Product
- azido-PEG7-t-Butyl ester 2596867-40-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23