ChemicalBook > CAS DataBase List > 2-Chloro-1,3,2-dioxaphospholane-2-oxide

2-Chloro-1,3,2-dioxaphospholane-2-oxide

Product Name
2-Chloro-1,3,2-dioxaphospholane-2-oxide
CAS No.
6609-64-9
Chemical Name
2-Chloro-1,3,2-dioxaphospholane-2-oxide
Synonyms
2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE;ETHYLENE CHLOROPHOSPHATE;ETHYLENE CYCL-CHLOROPHOSPHATE;Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane);Ethylene chl;2-chloro-1,3,2;CYCLIC CHLOROPHOSPHATE;Ethylene chlorophosphate, tech. 90%;Ethylene glycol chlorophosphate, 95%;2-chloro-1,3,2λ?-dioxaphospholan-2-one
CBNumber
CB0664909
Molecular Formula
C2H4ClO3P
Formula Weight
142.48
MOL File
6609-64-9.mol
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2-Chloro-1,3,2-dioxaphospholane-2-oxide Property

Melting point:
12-14 °C
Boiling point:
89-91 °C0.8 mm Hg(lit.)
Density 
1.55 g/mL at 25 °C(lit.)
vapor pressure 
1.06hPa at 25℃
refractive index 
n20/D 1.45(lit.)
Flash point:
>230 °F
storage temp. 
-20°C
solubility 
Chloroform (Soluble), Ethyl Acetate (Slightly)
form 
Solid or Film
color 
White to off-white
Water Solubility 
Miscible with water and chloroform.
Sensitive 
Moisture Sensitive
BRN 
606582
Stability:
Extremely moisture sensitive
InChIKey
SBMUNILHNJLMBF-UHFFFAOYSA-N
LogP
-0.485 at 25℃ and pH7
CAS DataBase Reference
6609-64-9(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
14-34
Safety Statements 
26-36/37/39-45-8-25-27
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
F 
10
HazardClass 
8
PackingGroup 
II
HS Code 
29209090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
377953
Product name
2-Chloro-1,3,2-dioxaphospholane 2-oxide
Packaging
5g
Price
$154
Updated
2024/03/01
TCI Chemical
Product number
C1250
Product name
2-Chloro-2-oxo-1,3,2-dioxaphospholane
Purity
>95.0%(GC)(T)
Packaging
5g
Price
$85
Updated
2024/03/01
TCI Chemical
Product number
C1250
Product name
2-Chloro-2-oxo-1,3,2-dioxaphospholane
Purity
>95.0%(GC)(T)
Packaging
25g
Price
$261
Updated
2024/03/01
Alfa Aesar
Product number
A18320
Product name
Ethylene chlorophosphate
Purity
95%
Packaging
5g
Price
$77.7
Updated
2023/06/20
Alfa Aesar
Product number
A18320
Product name
Ethylene chlorophosphate
Purity
95%
Packaging
25g
Price
$290
Updated
2023/06/20
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2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties,Usage,Production

Chemical Properties

clear colourless liquid

Uses

Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.

Uses

2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:

  • 2-methacryloyloxyethylphosphorylcholine
  • miltefosine (hexadecylphosphocholine, MT) analogs
  • phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
  • uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
  • adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
  • structurally related phospholipids which are either conformationally restricted or flexible
  • phosphatidylcholines

Uses

2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.

General Description

2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.

Purification Methods

It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.]

2-Chloro-1,3,2-dioxaphospholane-2-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-1,3,2-dioxaphospholane-2-oxide Suppliers

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View Lastest Price from 2-Chloro-1,3,2-dioxaphospholane-2-oxide manufacturers

Hubei Langyou International Trading Co., Ltd
Product
2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
Price
US $1000.00/KG
Min. Order
10g
Purity
99%
Supply Ability
20tons
Release date
2021-09-01
Hebei Mojin Biotechnology Co., Ltd
Product
2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-07
Hebei Guanlang Biotechnology Co., Ltd.
Product
2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
Price
US $19.90/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-04-23

6609-64-9, 2-Chloro-1,3,2-dioxaphospholane-2-oxideRelated Search:

INDIUM TIN OXIDE Cyclopentyl chloride Phosphorus oxybromide Pralidoxime Chloride Bromocyclopentane Methylcyclopentane ETHYLENE OXIDE Fluroxypyr NITRIC OXIDE Cyclopentane Zinc oxide Chromium(III) oxide (Diethoxymethyl)diphenylphosphine oxide NITROUS OXIDE (4R,5R)-2-CHLORO-4,5-DIMETHYL-1,3,2-DIOXAPHOSPHOLANE 2-OXIDE DIMETHYL PHOSPHOROCHLORIDATE Difluorochloromethane 2-Chloro-1,3,2-dioxaphospholane

  • Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane)
  • 2-Chloro-1,3-dioxa-2-phosphacyclopentane 2-oxide
  • Ethylene chlorophosphate, tech. 90%
  • 2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene cycl-chlorophosphate
  • 2-Chloro-1,3,2-dioxaphospholane-2-oxide, Ethylene cycl-chlorophosphate
  • 1,3,2-Dioxaphospholane, 2-chloro-, 2-oxide
  • CYCLIC CHLOROPHOSPHATE
  • Ethylene glycol chlorophosphate, 95%
  • 2-Chloro-1,3,2-dioxaphospholane-2-oxide,95%
  • Ethylene chl
  • ETHYLENE CHLOROPHOSPHATE
  • ETHYLENE CYCL-CHLOROPHOSPHATE
  • 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE
  • 2-CHLORO-1,3,2-DIOXAPHOSPHOLANE-2-OXIDE
  • 2-Chloro-1,2,3-dioxaphospholane-2-oxide
  • 2-Chloro-2-oxo-1,3,2-dioxaphospholane &gt
  • 2-chloro-2-oxo-1,3, 2-dioxophosphorus heterocyclopentane
  • 2-Chloro-1,3,2-dioxaphospholane-2-oxide/ Ethylene Chlorophosphate
  • 2-Chloro-1,3,2-dioxaphospholane-2-oxide (Technical Grade)
  • 2-chloro-1,3,2λ?-dioxaphospholan-2-one
  • 2-chloro-1,3,2
  • 2-chloro-2-oxo-1,3, 2-dioxophosphoheterocyclopentane
  • 2-Chloro-2-Oxido-1,3,2- Dioxaphospholane
  • 6609-64-9
  • C2H4ClO3P
  • Organic Building Blocks
  • Phosphorus Halides
  • Phosphorus Compounds
  • Building Blocks
  • Phosphorylating Agents
  • DNA / RNA Synthesis
  • Phosphorylation
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Phosphorylating and Phosphorothioating Agents
  • Phosphorylation
  • Protecting Agents, Phosphorylating Agents & Condensing Agents
  • Synthetic Organic Chemistry