2-Chloro-1,3,2-dioxaphospholane-2-oxide
- Product Name
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide
- CAS No.
- 6609-64-9
- Chemical Name
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide
- Synonyms
- 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE;ETHYLENE CHLOROPHOSPHATE;ETHYLENE CYCL-CHLOROPHOSPHATE;Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane);Ethylene chl;2-chloro-1,3,2;CYCLIC CHLOROPHOSPHATE;Ethylene chlorophosphate, tech. 90%;Ethylene glycol chlorophosphate, 95%;2-chloro-1,3,2λ?-dioxaphospholan-2-one
- CBNumber
- CB0664909
- Molecular Formula
- C2H4ClO3P
- Formula Weight
- 142.48
- MOL File
- 6609-64-9.mol
2-Chloro-1,3,2-dioxaphospholane-2-oxide Property
- Melting point:
- 12-14 °C
- Boiling point:
- 89-91 °C0.8 mm Hg(lit.)
- Density
- 1.55 g/mL at 25 °C(lit.)
- vapor pressure
- 1.06hPa at 25℃
- refractive index
- n20/D 1.45(lit.)
- Flash point:
- >230 °F
- storage temp.
- -20°C
- solubility
- Chloroform (Soluble), Ethyl Acetate (Slightly)
- form
- Solid or Film
- color
- White to off-white
- Water Solubility
- Miscible with water and chloroform.
- Sensitive
- Moisture Sensitive
- BRN
- 606582
- Stability:
- Extremely moisture sensitive
- InChIKey
- SBMUNILHNJLMBF-UHFFFAOYSA-N
- LogP
- -0.485 at 25℃ and pH7
- CAS DataBase Reference
- 6609-64-9(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 14-34
- Safety Statements
- 26-36/37/39-45-8-25-27
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 10
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29209090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 377953
- Product name
- 2-Chloro-1,3,2-dioxaphospholane 2-oxide
- Packaging
- 5g
- Price
- $154
- Updated
- 2024/03/01
- Product number
- C1250
- Product name
- 2-Chloro-2-oxo-1,3,2-dioxaphospholane
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $85
- Updated
- 2024/03/01
- Product number
- C1250
- Product name
- 2-Chloro-2-oxo-1,3,2-dioxaphospholane
- Purity
- >95.0%(GC)(T)
- Packaging
- 25g
- Price
- $261
- Updated
- 2024/03/01
- Product number
- A18320
- Product name
- Ethylene chlorophosphate
- Purity
- 95%
- Packaging
- 5g
- Price
- $77.7
- Updated
- 2023/06/20
- Product number
- A18320
- Product name
- Ethylene chlorophosphate
- Purity
- 95%
- Packaging
- 25g
- Price
- $290
- Updated
- 2023/06/20
2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties,Usage,Production
Chemical Properties
clear colourless liquid
Uses
Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.
Uses
2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:
- 2-methacryloyloxyethylphosphorylcholine
- miltefosine (hexadecylphosphocholine, MT) analogs
- phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
- uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
- adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
- structurally related phospholipids which are either conformationally restricted or flexible
- phosphatidylcholines
Uses
2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.
General Description
2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.
Purification Methods
It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.]
2-Chloro-1,3,2-dioxaphospholane-2-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-1,3,2-dioxaphospholane-2-oxide Suppliers
View Lastest Price from 2-Chloro-1,3,2-dioxaphospholane-2-oxide manufacturers
- Product
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
- Price
- US $1000.00/KG
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2021-09-01
- Product
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-07
- Product
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide 6609-64-9
- Price
- US $19.90/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-04-23