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Ticlopidine hydrochloride

Product Name
Ticlopidine hydrochloride
CAS No.
53885-35-1
Chemical Name
Ticlopidine hydrochloride
Synonyms
Soper;tiklid;53-32c;4-c-32;ticlid;Tiklyd;ticlodix;Iparazin;panaldine;ticlodone
CBNumber
CB0674371
Molecular Formula
C14H14ClNS.ClH
Formula Weight
300.25
MOL File
53885-35-1.mol
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Ticlopidine hydrochloride Property

Melting point:
205°C
Density 
1.37 g/cm3
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Sparingly soluble in water and in anhydrous ethanol, very slightly soluble in ethyl acetate.
pka
7.64(at 25℃)
form 
Solid
color 
White
Water Solubility 
Soluble to 100 mM in water and to 100 mM in DMSO.
λmax
295nm(H2O)(lit.)
Merck 
14,9421
CAS DataBase Reference
53885-35-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-37/39-26
WGK Germany 
3
RTECS 
XJ9089100
HS Code 
2934990002
Toxicity
LD50 in mice (mg/kg/24 hrs): 55 i.v.; >300 orally (Castaigne)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T6654
Product name
Ticlopidine hydrochloride
Purity
analytical standard, for drug analysis
Packaging
1g
Price
$39.4
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3367
Product name
Ticlopidine hydrochloride
Purity
certified reference material, pharmaceutical secondary standard
Packaging
300MG
Price
$208
Updated
2024/03/01
Sigma-Aldrich
Product number
1667144
Product name
Ticlopidine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$261.6
Updated
2024/03/01
TCI Chemical
Product number
T3110
Product name
Ticlopidine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$61
Updated
2024/03/01
TCI Chemical
Product number
T3110
Product name
Ticlopidine Hydrochloride
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$159
Updated
2024/03/01
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Ticlopidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Ticlid,Millot,France,1978

Uses

Ticlopidine hydrochloride is a selective P2Y12 receptor antagonist. It inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo.

Uses

An antithrombotic. a platelet aggregation inhibitor

Uses

mucolytic, antibacterial, surface active agent

Manufacturing Process

A solution of thieno[3,2-c]pyridine (13.5 g; 0.1 mol) and 2-chlorobenzyl chloride (17.7 g) in acetonitrile (150 ml) is boiled during 4 hours. After evaporation of the solvent, the solid residue consists of 5-(2- chlorobenzyl)-thieno[3,2-c]pyridinium chloride which melts at 166°C (derivative n° 30). This compound is taken up into a solution comprising ethanol (300 ml) and water (100 ml). Sodium borohydride (NaBH4)(20 g) is added portionwise to the solution maintained at room temperature. The reaction medium is maintained under constant stirring during 12 hours and is then evaporated. The residue is taken up into water and made acidic with concentrated hydrochloric acid to destroy the excess reducing agent. The mixture is then made alkaline with ammonia and extracted with ether. The ether solution is washed with water, dried and evaporated. The oily residue is dissolved in isopropanol (50 ml) and hydrochloric acid in ethanol solution is then added thereto.
After filtration and recrystallization from ethanol, there are obtained 5-(2- chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride crystals (yield: 60%) having a melting point (Koefler block) of 190°C.

Therapeutic Function

Platelet aggregation inhibitor

Biological Activity

Selective P2Y 12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo .

Ticlopidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ticlopidine hydrochloride Suppliers

Suzhou Philip Johnson Pharmaceutical Co., Ltd
Tel
0512-82780333-8506
Fax
0512-82782911,82780556
Email
wangchunhua@homesunpharm.com
Country
China
ProdList
57
Advantage
50
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
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View Lastest Price from Ticlopidine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ticlopidine hydrochloride 53885-35-1
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min
Supply Ability
500kg
Release date
2021-09-22
Hebei Weibang Biotechnology Co., Ltd
Product
Ticlopidine hydrochloride 53885-35-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-31
Hebei Chuanghai Biotechnology Co,.LTD
Product
Ticlopidine Hydrochloride 53885-35-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2024-08-20

53885-35-1, Ticlopidine hydrochlorideRelated Search:


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