ChemicalBook > CAS DataBase List > 3-Aminobenzamide

3-Aminobenzamide

Product Name
3-Aminobenzamide
CAS No.
3544-24-9
Chemical Name
3-Aminobenzamide
Synonyms
3-AB;3-ABA;INO-1001;PARP-IN-1;3-AB, 3-ABA;3-amino-benzamid;M-AMINOBENZAMIDE;3-AMINOBENZAMIDE;m-amino-benzamid;Benzamide, m-amino-
CBNumber
CB0681621
Molecular Formula
C7H8N2O
Formula Weight
136.15
MOL File
3544-24-9.mol
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3-Aminobenzamide Property

Melting point:
115-116 °C (lit.)
Boiling point:
250.42°C (rough estimate)
Density 
1.1778 (rough estimate)
refractive index 
1.5769 (estimate)
storage temp. 
room temp
solubility 
ethanol: 50 mg/mL, clear, faintly yellow
form 
powder
pka
16.26±0.50(Predicted)
color 
white to off-white
Water Solubility 
Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).
Sensitive 
Light Sensitive
BRN 
2802373
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
LogP
-0.330
CAS DataBase Reference
3544-24-9(CAS DataBase Reference)
NIST Chemistry Reference
3-NH2-C6H4CONH2(3544-24-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
3077
WGK Germany 
3
RTECS 
CU8992000
HS Code 
29242990
Hazardous Substances Data
3544-24-9(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0788
Product name
3-Aminobenzamide
Purity
≥99% (TLC)
Packaging
1g
Price
$432
Updated
2024/03/01
Sigma-Aldrich
Product number
165350
Product name
PARP Inhibitor I, 3-ABA
Packaging
100mg
Price
$56.2
Updated
2024/03/01
TCI Chemical
Product number
A0630
Product name
3-Aminobenzamide
Purity
>98.0%(T)
Packaging
5g
Price
$40
Updated
2024/03/01
TCI Chemical
Product number
A0630
Product name
3-Aminobenzamide
Purity
>98.0%(T)
Packaging
25g
Price
$135
Updated
2024/03/01
Alfa Aesar
Product number
A10793
Product name
3-Aminobenzamide, 98%
Packaging
5g
Price
$54.65
Updated
2024/03/01
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3-Aminobenzamide Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

Chemical Properties

beige powder

Uses

The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.

Uses

3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects.

Definition

ChEBI: A substituted aniline that is benzamide in which one of the meta- hydrogens is replaced by an amino group.

Biochem/physiol Actions

3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.

References

1) Purnell and Whish (1980), Novel inhibitors of poly(ADP-ribose) synthetase; Biochem. J., 185 775 2) Kuo et al. (1996), Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells; Biochem. Biophys. Res. Commun., 219 502 3) Malorni et al. (1995), 3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion; Biochem. Biophys. Res. Commun., 207 715 4) Heller et al. (1995), Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells; J. Biol. Chem., 270 11176

3-Aminobenzamide Preparation Products And Raw materials

Raw materials

Methanesulfonic acid Sodium sulfate Dichloromethane 3-Aminobenzonitrile Aluminum oxide

Preparation Products

3-NITROSOBENZAMIDE
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3-Aminobenzamide Suppliers

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View Lastest Price from 3-Aminobenzamide manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
3-Aminobenzamide 3544-24-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-10
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Aminobenzamide 3544-24-9
Price
US $9.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
100tons
Release date
2024-08-16
Shaanxi Dideu Medichem Co. Ltd
Product
3-Aminobenzamide 3544-24-9
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19

3544-24-9, 3-AminobenzamideRelated Search:

Benzamide 3-Aminobenzoic acid Chlorantraniliprole Metrizamide 3,5-Dinitrobenzamide N-(4-Aminobutyl)-N-ethylisoluminol 4-AMINO-3,5-DINITROBENZAMIDE 4-Nitrophthalhydrazide (R)-(+)-1-(4-Methylphenyl)ethylamine 3-Nitrophthalhydrazide 2-AB, 2-Aminobenzamide,2-AMINOBENZAMIDE p-Aminobenzamide 4-Nitrophthalimide XYLIDYL BLUE I SODIUM SALT Luminol 4-Aminophthalhydrazide 2-[2-HYDROXY-3-(2,4-XYLYLCARBAMOYL)-1-NAPHTHYLAZO]PHENOL (R)-(-)-N-(3,5-DINITROBENZOYL)-ALPHA-PHENYLETHYLAMINE

  • M-AMINOBENZAMIDE
  • 3-ABA
  • 3-AMINOBENZAMIDE
  • PARP Inhibitor I, 3-ABA
  • PARP Inhibitor I, 3-ABA - CAS 3544-24-9 - Calbiochem
  • 3-AMINOBENZAMIDE;INO1001;INO 1001
  • INO-1001 (3-Aminobenzamide
  • Aminobenzamide, 3- - AB, 3- | ABA, 3-
  • 3-amino-benzamid
  • Benzamide, 3-amino-
  • Benzamide, m-amino-
  • m-amino-benzamid
  • 3-AB
  • m-Amino Benzamide 3-Amino Benzamide
  • 3-AB, 3-ABA
  • 3-Aminobenzamide,3-AB, 3-ABA
  • INO-1001
  • 3-AMinobenzaMide, 98% 1GR
  • 3-AMinobenzaMide, 98% 5GR
  • Benzamide, 3-amino- (9CI)
  • 3-Aminobenzamide,98%
  • META-AMINOBENZAMIDE
  • 3-Aminobenzamide &gt
  • PARP-IN-1
  • PARP-IN-1 (3-aminobenzamide
  • 3-Aminobenzamide (3-AB), PARP inhibitor
  • 3544-24-9
  • PARP
  • PARP Regulators
  • Organic Building Blocks
  • Building Blocks
  • Apoptosis and Cell Cycle
  • BioChemical
  • Amides
  • Cell Biology
  • Carbonyl Compounds
  • Cell Signaling and Neuroscience
  • A-AM
  • Amides
  • Bioactive Small Molecules
  • AMIDE
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Inhibitors
  • Inhibitor
  • Building Blocks
  • Carbonyl Compounds
  • Cell Biology
  • Chemical Synthesis
  • Organic Building Blocks