RO 20-1724

Product Name: RO 20-1724
CAS No.: 29925-17-5
Chemical Name: RO 20-1724
Synonyms: RO 20-1724;ro 20-172;R 020-1724;Ro-20-1724 - CAS 29925-17-5 - Calbiochem;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE;4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE;4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE;4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid;4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
CBNumber: CB0710844
Molecular Formula: C15H22N2O3
Formula Weight: 278.35
MOL File: 29925-17-5.mol

More

Less

RO 20-1724 Property

Boiling point:: 483.8±25.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: ethanol: 7 mg/mL
form: solid
pka: 14.54±0.40(Predicted)
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
CAS DataBase Reference: 29925-17-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B8279
Product name: 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one
Purity: solid
Packaging: 100mg
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: 557502
Product name: Ro-20-1724
Packaging: 100mg
Price: $99.4
Updated: 2024/03/01

Cayman Chemical

Product number: 18272
Product name: Ro 20-1724
Purity: ≥95%
Packaging: 25mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18272
Product name: Ro 20-1724
Purity: ≥95%
Packaging: 50mg
Price: $50
Updated: 2024/03/01

Sigma-Aldrich

Product number: B8279
Product name: 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one
Purity: solid
Packaging: 500mg
Price: $512
Updated: 2024/03/01

More

Less

RO 20-1724 Chemical Properties,Usage,Production

Description

RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable

Uses

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.

Uses

Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.

Definition

ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.

Biological Activity

Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Biochem/physiol Actions

Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.

storage

Store at RT

References

1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19

RO 20-1724 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

RO 20-1724 Suppliers

China 69 Germany 2 Japan 2 Switzerland 2 United Kingdom 6 United States 20 USA 1 Global 102

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Focus Biomolecules

Tel: --
Fax: --
Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Biochemicals.net

Tel: --
Fax: --
Country: United States
ProdList: 40
Advantage: 47

ASDI Incorporated

Tel: --
Fax: --
Email: customerservice@asdi.net
Country: United States
ProdList: 6922
Advantage: 67

Kainic.com

Tel: --
Fax: --
Email: info@Kainic.com
Country: United States
ProdList: 330
Advantage: 38

EMD Biosciences, Inc.

Tel: --
Fax: --
Email: technical@calbiochem.com
Country: United States
ProdList: 6529
Advantage: 66

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

A.G. Scientific, Inc.

Tel: --
Fax: --
Email: support@agscientific.com
Country: United States
ProdList: 1066
Advantage: 71

BIOMOL INTERNATIONAL, LP

Tel: --
Fax: --
Email: info@biomol.com
Country: United States
ProdList: 1499
Advantage: 77

More

Less

View Lastest Price from RO 20-1724 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: RO 20-1724 29925-17-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

29925-17-5, RO 20-1724Related Search:

ZARDAVERINE S- (+)-Rolipram ETAZOLATE BRL 50481 Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE EHNA HYDROCHLORIDE 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE 3-ETHOXY-4-METHOXYPHENETHYLAMINE 3-ETHOXYPHENETHYLAMINE 3-(3-METHOXY-PHENYL)-PROPYLAMINE RO 20-1724 2-Imidazolidinone, 4-((3-(cyclopentyloxy)-4-methoxyphenyl)methyl)- AKOS BB-3072

4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE

4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE

4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE

4-[(3-BUTOXY-4-METHOXYPHENYL)METHYL]-2-IMIDAZOLIDINONE

4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE

ro 20-172

RO 20-1724

4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one

Ro-20-1724 - CAS 29925-17-5 - Calbiochem

2-Imidazolidinone, 4-[(3-butoxy-4-methoxyphenyl)methyl]-

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid

R 020-1724

neuroprotective,Ro 201724,Ro 20-174,Ro 20 1724,Ro 20-1724,phosphodiesterase,cognitive,cAMP,antioxidant,inhibit,Inhibitor,Phosphodiesterase (PDE)

29925-17-5

Inhibitor of cAMP phosphodiesterase. IC50 33 uM in vascular smooth muscle of the aorta.

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Phosphodiesterase Inhibitors

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide Metabolism

Cyclic Nucleotide related

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase.