5-BROMOCYTIDINE
- Product Name
- 5-BROMOCYTIDINE
- CAS No.
- 3066-86-2
- Chemical Name
- 5-BROMOCYTIDINE
- Synonyms
- 5-Br-Cr;5-Br-Cytidine;5-BROMOCYTIDINE;Cytidine, 5-bromo-;5-Bromo-D-cytidine;5-BROMOCYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM;4-amino-5-bromo-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;4-amino-5-bromo-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one;4-Amino-5-bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
- CBNumber
- CB0724052
- Molecular Formula
- C9H12BrN3O5
- Formula Weight
- 322.11
- MOL File
- 3066-86-2.mol
5-BROMOCYTIDINE Property
- Melting point:
- 183-185 °C
- Boiling point:
- 555.4±60.0 °C(Predicted)
- Density
- 2.28±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 13.48±0.70(Predicted)
- form
- Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B4165
- Product name
- 5-Bromocytidine
- Packaging
- 500MG
- Price
- $330
- Updated
- 2025/07/31
- Product number
- 295426
- Product name
- 5-Bromocytidine
- Packaging
- 500mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- B701358
- Product name
- 5-Bromocytidine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- NB06281
- Product name
- 5-Bromocytidine
- Packaging
- 5G
- Price
- $393.8
- Updated
- 2021/12/16
- Product number
- 098565
- Product name
- 5-Bromocytidine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $395
- Updated
- 2021/12/16
5-BROMOCYTIDINE Chemical Properties,Usage,Production
Description
5-Bromocytidine is a pyrimidine nucleoside. 5-Bromocytidine is used in the synthesis of substituted cytidine analogs identification of potent inhibitor of viral rnadependent RNA polymerases and has been shown to inhibit the replication of influenza virus in cell culture.
Uses
5-Bromocytidine is a useful research chemical used in the preparation and synthesis of substituted cytidine analogs identification of potent inhibitor of viral rnadependent RNA polymerases.
Synthesis
65-46-3
3066-86-2
The general procedure for the synthesis of 4-amino-5-bromo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one from cytidine was as follows: using a typical method of bromination of unprotected nucleosides, 1,3-dibromo-5,5-dimethylglycolactonium (DBH, 323 mg, 1.13 mmol ) was added to a stirred solution of cytidine (1d, 500 mg, 2.05 mmol) in N,N-dimethylformamide (DMF, 5 mL). The reaction mixture was stirred at room temperature for 20 min or monitored by thin layer chromatography (TLC) until the starting material completely disappeared and a less polar product was formed. Subsequently, the volatile solvent was evaporated under reduced pressure and the residue was co-evaporated with acetonitrile (MeCN) to remove the residual DMF.The resulting light-colored solid was recrystallized from hot acetone to give the target product 2d (500 mg, 75% yield) as colorless crystals with physicochemical properties consistent with those reported in the literature.
References
[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 30, p. 5634 - 5644
[2] Synthesis, 2009, # 23, p. 3957 - 3962
[3] Tetrahedron Letters, 2012, vol. 53, # 26, p. 3333 - 3336
[4] Molecules, 2013, vol. 18, # 10, p. 12740 - 12750
[5] Journal of the American Chemical Society, 1995, vol. 117, # 2, p. 704 - 714
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View Lastest Price from 5-BROMOCYTIDINE manufacturers
- Product
- 5-Bromocytidine 3066-86-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- 100kgs
- Release date
- 2021-09-07
- Product
- 5-BROMOCYTIDINE 3066-86-2
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-08-02