2'-O-Methyluridine

Product Name: 2'-O-Methyluridine
CAS No.: 2140-76-3
Chemical Name: 2'-O-Methyluridine
Synonyms: 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxyMethyl)-3-Methoxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;OMe-rU;2'-OMe-Ur;2'-OMe-rU;2'-O-Me-U;2'-OMe-Ur;2'-OMe Uridine;2-Methyoxy uridine;2'-O-METHYLURIDINE;2'-O-Methyluridine
CBNumber: CB8397539
Molecular Formula: C10H14N2O6
Formula Weight: 258.23
MOL File: 2140-76-3.mol

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2'-O-Methyluridine Property

Melting point:: 154-156°C
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 9.39±0.10(Predicted)
form: Powder
color: White to Off-white
PH: ～9.3
λmax: 261nm(MeOH)(lit.)
InChI: InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1
InChIKey: SXUXMRMBWZCMEN-ZOQUXTDFSA-N
SMILES: OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1O
CAS DataBase Reference: 2140-76-3(CAS DataBase Reference)

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 24/25
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2290
Product name: 2'-O-Methyluridine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $65
Updated: 2024/03/01

TCI Chemical

Product number: M2290
Product name: 2'-O-Methyluridine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $195
Updated: 2024/03/01

Alfa Aesar

Product number: J64897
Product name: 2'-O-Methyluridine, 99%
Packaging: 1g
Price: $33.3
Updated: 2023/06/20

TRC

Product number: M338200
Product name: 2''-O-MethylUridine
Packaging: 50g
Price: $1245
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM04259
Product name: 2'-O-Methyluridine
Packaging: 50g
Price: $350
Updated: 2021/12/16

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2'-O-Methyluridine Chemical Properties,Usage,Production

Description

2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands.

Chemical Properties

White Solid

Uses

Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Uses

Uridine analog. 2'-O-Methyluridine is used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Definition

ChEBI: A methyluridine that consists of uridine bearing a single methyl substituent located at position O-2' on the ribose ring.

Source

2'-O-Methyluridine is found in rRNA, snRNA, snoRNA and tRNA of Archaea, Bacteria, and Eukaryota[1].

References

[1] Agota Au?ynait?. “Identification of a 2’-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries.” Molecules 23 11 (2018).

2'-O-Methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-Methyluridine Suppliers

Americas 1 Canada 2 China 274 Europe 3 Germany 3 India 8 Japan 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 8 United States 40 Global 343

Jiangsu Synthgene Biotechnology Co.,Ltd.

Tel: 18136497538
Email: znf@syngenebio.com
Country: China
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Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-0553-5842013-801-801 18155347026
Fax: 086-553-5843138
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Country: China
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Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: sales@nuowei-chem.com
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Jinan Kabotang Biological Technology Co.,Ltd.

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Zhengzhou First biochem technology Co.,Ltd.

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Email: firstbio@126.com
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Shandong utilizing biological technology co., LTD

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Nugene Biopharm Science (Hangzhou) Co., Ltd.

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Shanghai Bolu Biotechnology Co., Ltd

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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
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View Lastest Price from 2'-O-Methyluridine manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd

Product: 2'-O-Methyluridine 2140-76-3
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 1000
Release date: 2025-01-03

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2'-O-Methyluridine 2140-76-3
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 98%min HPLC
Supply Ability: 10KGS
Release date: 2021-06-28

Hefei Huana Biomedical Technology Co.,Ltd.

Product: 2'-OME-rU 2140-76-3
Price: US $0.00/g
Min. Order: 100g
Purity: ≥98%(HPLC)
Supply Ability: 20t
Release date: 2023-03-23

2140-76-3, 2'-O-MethyluridineRelated Search:

(Trifluoromethoxy)benzene Trifluridine Doxifluridine 2',3',5'-Tri-O-acetyluridine uridine diphosphate glucose {= UDP-glucose} Methyluridine 2',3',5'-TRI-O-BENZOYLURIDINE 2′,3′-O-Isopropylideneuridine 5-METHY-5-METHYLURIDINE,5-METHYL-2'-O-METHYLURIDINE,2'-O-METHYL-5-METHYLURIDINE 2'-O-Methyl-5'-O-DMT-Uridine 2'-OMe-U-CE Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite 2,2'-ANHYDRO-5-METHYLURIDINE,2,2'β-Oxy-2-deoxo-2,3-didehydro-2'-deoxy-5-methyluridine,O2,2'-Anhydro-5-methyluridine 2'-DEOXY-2'-FLUORO-5-METHYLURIDINE 3-METHYLURIDINE 2'-C-Methyluridine 3',5'-DI-O-BENZOYL-5-FLUORO-2'-O-METHYLURIDINE 5'-O-(DMT)-5-IODO-2'-O-METHYLURIDINE

2'-O-METHYLURIDINE (CHIRAL)

2''-O-METHYLURIDINE CRYSTALLINE

1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

2'-O-METHYLURIDINE

1-[(2R,3R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHOXYOXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE

2'-O-Methyluridine 98+%

2'-O-Methyluridine, 98.0 %

2-Methyoxy uridine

1-[(2S,3S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione

1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxyMethyl)-3-Methoxytetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione

1-(2-O-Methyl-beta-D-ribofuranosyl)uracil

2'-OMe-Ur

2'-O-Methyluridine&gt

Uridine, 2'-O-methyl-

2'-OMe-rU

2'-O-Methyluridine USP/EP/BP

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

2’-O-Methyl uridine, RNA modified nucleoside Um

RNA modified nucleoside Um

1-((2S,3S,4S,5S)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

2 '- Methoxyuridine

OMe-rU

2'-O-Methyluridine

2'-OMe Uridine

2'-O-Me-U

2'-OMe-Ur

1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxy- tetrahydrofuran-2-yDpyrimidine-2,4(1H,3H)-dione

2’-Methyoxy uridine

2140-76-3

2140-79-3

2104-76-3

pyrimidine

Heterocycle-Pyrimidine series

Bases & Related Reagents

Carbohydrates & Derivatives

Heterocycles

Nucleotides

Pharmaceutical

2140-76-3

Nucleosides

Modified（deoxy）nucleoside

Nucleosides-2'-OMe Nucleosides