ChemicalBook > CAS DataBase List > CNQX

CNQX

Product Name
CNQX
CAS No.
115066-14-3
Chemical Name
CNQX
Synonyms
CNQX;CNOX;FG-9065;CNQX 2NA;CNQX DISODIUM;CNQX DISODIUM SALT;CNQX disodium salt hydrate;CNQX, AMPA / kainate antagonist;CNQX DISODIUM KAINATE/AMPA RECEPTOR;CNQX (FG-9065) (6-CYANO-7-NITROQUINO
CBNumber
CB0728641
Molecular Formula
C9H4N4O4
Formula Weight
232.15
MOL File
115066-14-3.mol
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CNQX Property

Melting point:
300 °C
Boiling point:
374.31°C (rough estimate)
Density 
1.5507 (rough estimate)
refractive index 
1.6590 (estimate)
RTECS 
VD1520000
storage temp. 
protect from light
solubility 
H2O: 10 mg/mL
form 
solid
pka
8.16±0.20(Predicted)
color 
orange to red
Stability:
Store Tightly Sealed at RT
CAS DataBase Reference
115066-14-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C127
Product name
CNQX
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$162
Updated
2024/03/01
Sigma-Aldrich
Product number
C127
Product name
CNQX
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$546
Updated
2024/03/01
Sigma-Aldrich
Product number
5.04914
Product name
CNQX - CAS 115066-14-3 - Calbiochem
Packaging
10mg
Price
$176
Updated
2024/03/01
Alfa Aesar
Product number
J63472
Product name
6-Cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione, 98%
Packaging
10mg
Price
$133.65
Updated
2024/03/01
Alfa Aesar
Product number
J63472
Product name
6-Cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione, 98%
Packaging
25mg
Price
$349.65
Updated
2024/03/01
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CNQX Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

CNQX disodium salt hydrate has been used as:

  • as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
  • as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
  • as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Uses

A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively

Uses

CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.

Definition

ChEBI: 6-Cyano-7-nitroquinoxaline-2,3-dione is a quinoxaline derivative.

Biological Activity

Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

storage

Room temperature

CNQX Preparation Products And Raw materials

Raw materials

Preparation Products

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CNQX Suppliers

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View Lastest Price from CNQX manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
6-Cyano-7-Nitroquinoxaline-2,3-Dione 115066-14-3
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-10-31
Zhuozhou Wenxi import and Export Co., Ltd
Product
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 115066-14-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

115066-14-3, CNQXRelated Search:

2-Nitrobenzonitrile N,N'-Dimethyloxalamide 2-HYDROXY-6-METHYLQUINOXALINE 3-Methyl-4-nitroaniline 1,2,3,4-TETRAHYDRO-QUINOXALINE 4-ACETAMIDOBENZONITRILE 2,3-DIHYDROXYQUINOXALINE 3,4-Diaminobenzonitrile 4-ACETAMIDO-2-METHYLNITROBENZENE 6-NITROQUINOXALINE-2,3-DIONE 2,5-Diaminobenzonitrile 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE 6-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINE 4-(N-Methylamino)benzonitrile CNQX N'-METHYL-4-NITROPHENYLENEDIAMINE-(1,2) PYRAZINE-2,3-DIOL N-(4-amino-3-methylphenyl)acetamide

  • 7-Nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile
  • 6-CYANO-7-NITROQUINOXALINE-2,3 (1H,4H)-DIONE
  • CNQX
  • CNQX 2NA
  • CNQX DISODIUM
  • CNQX DISODIUM SALT
  • FG-9065
  • CNQX DISODIUM KAINATE/AMPA RECEPTOR
  • CNQX (FG-9065) (6-CYANO-7-NITROQUINO
  • 2,3-Dioxo-7-nitroquinoxaline-6-carbonitrile
  • 6-Nitro-7-cyanoquinoxaline-2,3-dione
  • CNOX
  • 1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile
  • 7-Nitro-2,3-dihydroxyquinoxaline-6-carbonitrile
  • 6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
  • 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline
  • 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate
  • CNQX disodium salt hydrate
  • 7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile
  • 6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-
  • 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE
  • 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 2NA
  • 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM
  • 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM SALT
  • CNQX,6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
  • 1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxaline
  • CNQX, AMPA / kainate antagonist
  • 115066-14-3
  • 486724-17-2
  • C9H2N4Na2O4
  • C9H2N4O4Na2
  • C9H4N4O4
  • Cell Signaling and Neuroscience
  • BioChemical
  • Cell Biology
  • Ligand-Gated Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Heterocyclic Compounds
  • Neurochemicals
  • Glutamate receptor
  • Glutamate
  • Aromatics
  • Heterocycles