ChemicalBook > CAS DataBase List > Ethyl 4-methyl-1,3-oxazole-5-carboxylate

Ethyl 4-methyl-1,3-oxazole-5-carboxylate

Product Name: Ethyl 4-methyl-1,3-oxazole-5-carboxylate
CAS No.: 20485-39-6
Chemical Name: Ethyl 4-methyl-1,3-oxazole-5-carboxylate
Synonyms: EINECS 243-848-9;4-methyl-1,3-oxazole-5-carboxylate;ethyl 4-methyloxazole-5-carboxylate;5-(Ethoxycarbonyl)-4-methyl-1,3-oxazole;ETHYL 4-METHYL-1,3-OXAZOLE-5-CARBOXYLATE;Ethyl 4-Methyloxazole-5-carboxylate, 97+%;4-METHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;5-Oxazolecarboxylic acid, 4-methyl-, ethyl ester
CBNumber: CB0729936
Molecular Formula: C7H9NO3
Formula Weight: 155.15
MOL File: 20485-39-6.mol

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Ethyl 4-methyl-1,3-oxazole-5-carboxylate Property

Melting point:: 38 °C
Boiling point:: 62°C/1.5mmHg(lit.)
Density: 1.139±0.06 g/cm3(Predicted)
refractive index: 1.4680 to 1.4720
storage temp.: 2-8°C
form: clear liquid
pka: -0.80±0.14(Predicted)
color: Colorless to Light orange to Yellow
CAS DataBase Reference: 20485-39-6

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1270
Product name: Ethyl 4-Methyloxazole-5-carboxylate
Purity: >96.0%(GC)
Packaging: 1g
Price: $93
Updated: 2025/07/31

TRC

Product number: E926695
Product name: Ethyl 4-Methyloxazole-5-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0029739
Product name: ETHYL 4-METHYL-1,3-OXAZOLE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 2.5G
Price: $1065.66
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0029739
Product name: ETHYL 4-METHYL-1,3-OXAZOLE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $1295.03
Updated: 2021/12/16

AK Scientific

Product number: W4308
Product name: Ethyl 4-Methyloxazole-5-carboxylate
Packaging: 25g
Price: $548
Updated: 2021/12/16

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Ethyl 4-methyl-1,3-oxazole-5-carboxylate Chemical Properties,Usage,Production

Synthesis

584-08-7

609-15-4

20485-39-6

Example 1 Preparation of ethyl 4-methyl-5-oxazolecarboxylate: the compound was prepared according to the method described in French Patent No. 4,522,587. A mixture of 50.0 g (0.337 mol) of ethyl 2-chloroacetoacetate and 42.0 g (0.933 mol) of formamide was stirred and reacted at 120°C to 135°C for 18 hours. Upon completion of the reaction, the reaction mixture was cooled to 10°C using an ice bath. 300 mL of 1N potassium carbonate (K2CO3) solution was slowly added dropwise, taking care to control the rate of gas escape. After dropwise addition, the reaction mixture was mixed with 200 mL of benzene/ether (2:1, v/v), stirred and saturated with sodium chloride (NaCl). The insoluble material was removed by filtration, the organic layer (benzene/ether layer) was separated, washed with water, dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure. The resulting brown residue was distilled through a Kugelrohr distillation apparatus to give 14.8 g of white solid product with a melting point of 31 °C to 33 °C. The yield was 31%; nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3) data were as follows: δ 8.0 (single peak, 1H, C2H), 4.4 (quartet, J = 7 Hz, 2H, CH2), 2.5 (single peak, 3H, CH3), 1.4 (triple peak, 3H, CH3).

References

[1] Patent: US4303439, 1981, A

Ethyl 4-methyl-1,3-oxazole-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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20485-39-6, Ethyl 4-methyl-1,3-oxazole-5-carboxylateRelated Search:

Sulfamethoxazole RESMETHRIN Benzocaine Methyl acetate Urethane Ethyl formate Methylparaben Bensulfuron methyl Methyl acrylate Kresoxim-methyl 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID 4-METHYLOXAZOLE-5-METHANOL Thiophanate-methyl Methyl Parathion-methyl Ethyl chloroformate Methyl bromide 2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

4-METHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

ETHYL 4-METHYL-1,3-OXAZOLE-5-CARBOXYLATE

ethyl 4-methyloxazole-5-carboxylate

EINECS 243-848-9

Ethyl 4-Methyloxazole-5-carboxylate, 97+%

5-(Ethoxycarbonyl)-4-methyl-1,3-oxazole

4-methyl-1,3-oxazole-5-carboxylate

5-Oxazolecarboxylic acid, 4-methyl-, ethyl ester

20485-39-6

Esters

Oxazoles, Isoxazoles & Benzoxazoles