Phenyl-4-aminosalicylate
- Product Name
- Phenyl-4-aminosalicylate
- CAS No.
- 133-11-9
- Chemical Name
- Phenyl-4-aminosalicylate
- Synonyms
- FR 7;Tebamin;Tebanyl;fenamisal;NSC-40144;PHENYL PAS;p-Aminosalol;Pheny-PAS-Tebamin;Phenyl-PAS-Tebamin;TIMTEC-BB SBB000692
- CBNumber
- CB0734217
- Molecular Formula
- C13H11NO3
- Formula Weight
- 229.23
- MOL File
- 133-11-9.mol
Phenyl-4-aminosalicylate Property
- Melting point:
- 150-152 °C(lit.)
- Boiling point:
- 371.13°C (rough estimate)
- Density
- 1.2084 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 8.76±0.10(Predicted)
- form
- Solid
- color
- Off-White
- CAS DataBase Reference
- 133-11-9(CAS DataBase Reference)
- EPA Substance Registry System
- Phenyl 4-aminosalicylate (133-11-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- P309020
- Product name
- Phenyl4-Aminosalicylate
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 462417
- Product name
- Phenyl 4-Aminosalicylate
- Packaging
- 250mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- P309020
- Product name
- Phenyl4-Aminosalicylate
- Packaging
- 2.5g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- I555
- Product name
- Phenyl-4-aminosalicylate
- Packaging
- 1g
- Price
- $314
- Updated
- 2021/12/16
- Product number
- 48190
- Product name
- Phenyl4-Aminosalicylate
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
Phenyl-4-aminosalicylate Chemical Properties,Usage,Production
Chemical Properties
WHITE POWDER
Originator
Pheny-Pas-Teb-Amin ,Purdue Frederick, US,1959
Uses
Phenyl 4-Aminosalicylate is a reactant in the synthesis of p-aminosalicylic ester imines with antitubercular activity.
Uses
Antibacterial(tuberculostatic).
Definition
ChEBI: 4-amino-2-hydroxybenzoic acid phenyl ester is a carbonyl compound.
Manufacturing Process
183 g of p-nitrosalicylic acid are dissolved in 564 g of phenol by heating to 140°C to 150°C on an oil bath. When all the p-nitrosalicylic acid is dissolved, 153 g of phosphorus oxychloride are run in, drop by drop, over a period of about 2 hours, while maintaining the temperature at about 150°C. The still warm mixture is run into 2 liters of water with agitation. The precipitate formed is filtered off, washed with water until phenol is removed and then dried.
There are thus obtained 250 g of 2-hydroxy-4-nitrophenylbenzoate which melts at 154°C to 155°C.
In a hydrogenation autoclave are introduced 92 g of 2-hydroxy-4nitrophenylbenzoate preceded by 200 cc of ethyl acetate; Raney nickel, obtained from 30 g of alloy, is added with 300 cc of ethyl acetate. Hydrogenation under pressure (100 to 120 kg) at ordinary temperature is carried out during a period of about 12 hours. The nickel is filtered off and the ethyl acetate is removed by distillation on the water bath under a vacuum of 300 mm. There is thus obtained 80 g of crude damp 2-hydroxy-4amnophenylbenzoate which after recrystallization from isopropyl alcohol melts at 153°C.
brand name
Pheny-Pas-Tebamin (Purdue Frederick).
Therapeutic Function
Antibacterial (tuberculostatic)
Purification Methods
Crystallise the ester from EtOH (m 155o, also 149-150.5o), aqueous EtOH (m 147-149o), or isopropanol. It is tuberculostatic.[Beilstein 13 IV 1979.]
Phenyl-4-aminosalicylate Preparation Products And Raw materials
Raw materials
Preparation Products
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