4-Chloro-3-nitroanisole
- Product Name
- 4-Chloro-3-nitroanisole
- CAS No.
- 10298-80-3
- Chemical Name
- 4-Chloro-3-nitroanisole
- Synonyms
- 1-CHLORO-4-METHOXY-2-NITROBENZENE;2-CHLORO-5-METHOXYNITROBENZENE;dioxoaMine;Eramod Impurity 2;Iguratimod Impurity 4;Iguratimod Impurity 30;3-NITRO-4-CHLOROANISOLE;4-chloro-3-nitro-anisol;4-CHLORO-3-NITROANISOLE;4-CHLORO-3-NITROANISOLE,98%
- CBNumber
- CB0736059
- Molecular Formula
- C7H6ClNO3
- Formula Weight
- 187.58
- MOL File
- 10298-80-3.mol
4-Chloro-3-nitroanisole Property
- Melting point:
- 41-43 °C (lit.)
- Boiling point:
- 293°C
- Density
- 1.366
- refractive index
- 1.6000 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Amber
- BRN
- 640872
- InChI
- InChI=1S/C7H6ClNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3
- InChIKey
- HISHUMDTGXICEZ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=CC=C(OC)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 10298-80-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 116289
- Product name
- 4-Chloro-3-nitroanisole
- Purity
- 98%
- Packaging
- 25g
- Price
- $96.4
- Updated
- 2023/06/20
- Product number
- C1225
- Product name
- 4-Chloro-3-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- C381703
- Product name
- 4-Chloro-3-nitroanisole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR5423
- Product name
- 4-Chloro-3-nitroanisole
- Packaging
- 100g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 4654-5-X9
- Product name
- 4-Chloro-3-nitroanisole
- Packaging
- 100g
- Price
- $96
- Updated
- 2021/12/16
4-Chloro-3-nitroanisole Chemical Properties,Usage,Production
Chemical Properties
beige to ochre powder
Uses
4-Chloro-3-nitroanisole can be used as disperse azo dyes.
Uses
4-chloro-3-nitroanisole is used to synthesize a group of derivatives of 7-methanesulfonylamino-6-phenoxychromone at the pyrone and phenoxy rings.
Synthesis
96-96-8
10298-80-3
In a reaction vessel, a concentrated phosphoric acid solution with a mass fraction of 80% and 100 mL of water were added, followed by 4-amino-3-nitroanisole (2) 0.25 mol. The stirring speed was controlled to 230 rpm and the temperature of the solution was lowered to 9 °C. A solution configured from potassium nitrite 0.25 mol dissolved in 100 mL of water was added slowly. A further 200 mL of potassium bisulfite solution with a mass fraction of 55% was added to the reaction vessel, the reaction temperature was maintained at 8 °C, and the reaction lasted for 50 min. 0.30 mol of stannous bromide was dissolved in 130 mL of concentrated potassium chloride solution, and the diazonium salt solution was rapidly added to the stannous bromide solution at 19 °C and allowed to stand for 5 hours. Subsequently, the temperature of the solution was gradually raised to 70 °C until no gas escaped. The distillate was collected by steam distillation and extracted with acetone. The extracts were combined and washed sequentially with sodium bicarbonate solution and potassium chloride solution and finally dehydrated by activated alumina. After recovery of acetone, 43.71 g of yellow solid 4-chloro-3-nitroanisole was obtained in 93% yield.
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Patent: CN104292107, 2016, B. Location in patent: Paragraph 0030; 0031
[3] Patent: CN105439868, 2016, A. Location in patent: Paragraph 0014; 0015
[4] Tetrahedron Letters, 2010, vol. 51, # 51, p. 6769 - 6771
[5] Organic Process Research and Development, 2017, vol. 21, # 1, p. 44 - 51
4-Chloro-3-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-3-nitroanisole Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
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- 6700
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View Lastest Price from 4-Chloro-3-nitroanisole manufacturers
- Product
- 4-Chloro-3-nitroanisole 10298-80-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-28
- Product
- 4-Chloro-3-nitroanisole 10298-80-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 4-Chloro-3-nitroanisole 10298-80-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08