2-Bromo-5-fluoroanisole
- Product Name
- 2-Bromo-5-fluoroanisole
- CAS No.
- 450-88-4
- Chemical Name
- 2-Bromo-5-fluoroanisole
- Synonyms
- BUTTPARK 87\07-62;2-BROMO-5-FLUOROANISOLE;2-Bromo-5-fluoroanisole >2-Bromo-5-fluoroanisole98+%;2-bromo-5-fluorobenzane ether;2-methoxy-4-fluorobromobenzene;1-Bromo-4-fluoro-2-methoxybenzene;2-BroMo-5-fluoroanisole, 95.0%(GC);Benzene, 1-bromo-4-fluoro-2-methoxy-;2-Bromo-5-fluoroanisole ISO 9001：2015 REACH
- CBNumber
- CB0745262
- Molecular Formula
- C7H6BrFO
- Formula Weight
- 205.02
- MOL File
- 450-88-4.mol
2-Bromo-5-fluoroanisole Property
- Boiling point:
- 143-145 °C
- Density
- 1.5983
- refractive index
- 1.542
- Flash point:
- 90 °C
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow
- InChIKey
- KGYXKRGMSUHYCY-UHFFFAOYSA-N
- CAS DataBase Reference
- 450-88-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Harmful
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 682543
- Product name
- 2-Bromo-5-fluoroanisole
- Purity
- 99%
- Packaging
- 5g
- Price
- $179
- Updated
- 2022/05/15
- Product number
- B3875
- Product name
- 2-Bromo-5-fluoroanisole
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- B3875
- Product name
- 2-Bromo-5-fluoroanisole
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $442
- Updated
- 2025/07/31
- Product number
- B691890
- Product name
- 2-Bromo-5-fluoroanisole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB105377
- Product name
- 1-Bromo-4-fluoro-2-methoxybenzene
- Packaging
- 25g
- Price
- $110
- Updated
- 2021/12/16
2-Bromo-5-fluoroanisole Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid to pale yellow liquid
Uses
2-Bromo-5-fluoroanisole is a halogenated anisole compound, the chemical reactivity of which is mainly concentrated on the bromine atom on its benzene ring. It can be used as an organic synthesis intermediate and a synthetic raw material for drug molecules. For example, literature reports that the substance can be used for the preparation of the drug molecule anacetrapib.
Synthesis
77-78-1
147460-41-1
450-88-4
a) A suspension of 2-bromo-5-fluorophenol (20.0 g, 104.7 mmol) and potassium carbonate (21.71 g, 157.1 mmol) was formed in acetone (200 mL). To this suspension dimethyl sulfate (10.90 mL, 115.2 mmol) was slowly added. The reaction mixture was stirred at 60 °C for 2 h. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in a mixture of ether (200 mL) and water (100 mL) to separate the organic phase. The organic phase was washed sequentially with 2N aqueous hydrochloric acid (50 mL) and saturated sodium bicarbonate solution (50 mL), and then dried with anhydrous magnesium sulfate. The dried organic phase was evaporated from the solvent under reduced pressure to give the light yellow oily product 2-bromo-5-fluoroanisole (21.46 g, 100% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δ 7.45 (1H, dd, Ar-H), 6.70-6.55 (2H, m, Ar-H), 3.90 (3H, s, OCH3).
References
[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 29
[2] Patent: WO2004/43903, 2004, A1. Location in patent: Page 30
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 28
2-Bromo-5-fluoroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-5-fluoroanisole Suppliers
- Tel
- --
- Fax
- --
- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
- 58
View Lastest Price from 2-Bromo-5-fluoroanisole manufacturers
- Product
- 2-Bromo-5-fluoroanisole 450-88-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 2-Bromo-5-fluoroanisole 450-88-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.4%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 2-Bromo-5-fluoroanisole 450-88-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11