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Chalcone

Product Name
Chalcone
CAS No.
94-41-7
Chemical Name
Chalcone
Synonyms
(E)-CHALCONE;BENZALACETOPHENONE;CHALKONE;1,3-DIPHENYL-2-PROPENONE;CHALCONE;AI3-00946;NSC 26612;CCRIS 2213;Chalcone b;Chalcone,97%
CBNumber
CB0746254
Molecular Formula
C15H12O
Formula Weight
208.26
MOL File
94-41-7.mol
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Chalcone Property

Melting point:
55-59 °C
Boiling point:
208 °C25 mm Hg(lit.)
Density 
d462 1.0712
refractive index 
nD62 1.6458
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
dioxane: soluble1g/10 mL, clear, colorless
form 
Granular Powder
color 
Yellow
Merck 
14,2037
BRN 
1210466
LogP
3.080
CAS DataBase Reference
94-41-7(CAS DataBase Reference)
EPA Substance Registry System
2-Propen-1-one, 1,3-diphenyl- (94-41-7)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37
Safety Statements 
22-36/37/39-45
WGK Germany 
3
RTECS 
UD5576750
HS Code 
29143900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
11970
Product name
1,3-Diphenyl-2-propenone
Purity
≥98.0% (GC)
Packaging
100g
Price
$71.1
Updated
2023/06/20
TCI Chemical
Product number
C0071
Product name
Chalcone
Purity
>98.0%(GC)
Packaging
25g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
C0071
Product name
Chalcone
Purity
>98.0%(GC)
Packaging
100g
Price
$82
Updated
2024/03/01
TCI Chemical
Product number
C0071
Product name
Chalcone
Purity
>98.0%(GC)
Packaging
500g
Price
$200
Updated
2024/03/01
TRC
Product number
C291855
Product name
Chalcone
Packaging
250g
Price
$365
Updated
2021/12/16
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Chalcone Chemical Properties,Usage,Production

Description

Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.

Chemical Properties

light yellow powder

Uses

1,3-Diphenyl-2-propenone was used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines.

Uses

Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.

Definition

ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.

Preparation

Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.

This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).

Biological Activity

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Biochem/physiol Actions

1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.

Safety Profile

Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]

Chalcone Preparation Products And Raw materials

Raw materials

Acetone trans-Chalcone

Preparation Products

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Chalcone Suppliers

Americas 1 Belgium 1 China 145 Czech 1 Europe 3 Germany 4 India 24 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 9 United States 27 Global 225
TargetMol Chemicals Inc.
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View Lastest Price from Chalcone manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Chalcone 94-41-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-25
Hebei Weibang Biotechnology Co., Ltd
Product
Chalcone 94-41-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Henan Fengda Chemical Co., Ltd
Product
Chalcone 94-41-7
Price
US $8.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

94-41-7, ChalconeRelated Search:

2',4,4'-TRIHYDROXY-3-METHOXY CHALCONE 2',3,4,4'-Tetrahydroxy-trans-chalcone trans-Chalcone Styrene 4-Chloro-4'-methoxy-trans-chalcone (E)-2',4-Dihydroxy-4'-(β-D-glucopyranosyloxy)chalcone (E)-4'-(Dimethylamino)chalcone 4-Diethylamino-α-methyl-3',4',5'-trimethoxy-trans-chalcone 4-Amino-β-methyl-3',4',5'-trimethoxy-trans-chalcone α-Methyl-2',3',4'-trimethoxy-trans-chalcone 4-Acetylamino-3',4',5'-trimethoxy-trans-chalcone 4-Nitro-cis-chalcone 2'-HYDROXY-6'-METHYL-3,4-METHYLENEDIOXY CHALCONE 4-Butoxy-3',4',5'-trimethoxy-trans-chalcone 3-Dimethylamino-3',4',5'-trimethoxy-trans-chalcone 3,4'-Dinitro-trans-chalcone 4-Diethylamino-α-methyl-2',3',4'-trimethoxy-trans-chalcone 4-Nitro-3',4',5'-trimethoxy-trans-chalcone

  • styrylphenylketone
  • BENZALACETOPHENONE
  • BENZYLIDINEACETOPHENONE
  • (E)-CHALCONE
  • CHALKONE
  • 3-PHENYLACRYLOPHENONE
  • 1,3-DIPHENYLPROP-2-EN-1-ONE
  • 1,3-DIPHENYL-3-PROPEN-1-ONE
  • 1,3-DIPHENYL-2-PROPEN-I-ONE
  • 1,3-DIPHENYL-2-PROPENONE
  • (2E)-1,3-DIPHENYLPROP-2-EN-1-ONE
  • 2-BENZALACETOPHENONE
  • 2-BENZYLIDENEACETOPHENONE
  • Glycine USP24/Food grade
  • Benzylideneacetophenone97%Min
  • Chalcone, 96% (Benzylidenacetophenon)
  • Chalcone,98+%
  • trans-Chalcone,98+%
  • 2-Propen-1-one, 1,3-diphenyl-
  • (E)-1,3-diphenylprop-2-en-1-one
  • (2E)-1,3-Diphenyl-2-propen-1-one
  • 1,3-Diphenyl-1-propen-3-one
  • 1,3-diphenyl-2-propen-1-on
  • 1,3-Diphenylpropenone
  • 1-benzoyl-1-phenylethene
  • 1-Benzoyl-2-phenylethene
  • 1-Benzoyl-2-phenylethylene
  • 1-Phenyl-2-benzoylethylene
  • 3-phenyl-acrylophenon
  • Acrylophenone, 3-phenyl-
  • alpha-Benzylideneacetophenone
  • Benzylidenecetophenone
  • beta-Benzoylstyrene
  • beta-Phenylacrylophenone
  • Cinnamophenone
  • omega-Benzylideneacetophenone
  • Phenyl 2-phenylvinyl ketone
  • phenyl2-phenylvinylketone
  • Styryl phenyl ketone
  • PHENYL STYRYL KETONE
  • TRANS-BENZYLIDENEACETOPHENONE
  • BENZALACETOPHENONE pure
  • Chalcone,97%
  • Chalcone 97%
  • Chalcone 97% / trans-Benzylideneacetophenone
  • Chalcone, 97% 100GR
  • 2-Benzalacetophenone 2-Benzylideneacetophenone 1,3-Diphenyl-2-propen-1-one Phenyl Styryl Ketone
  • BENZYLIDENEACETOPHENONE FOR SYNTHESIS
  • 1,3-Diphenyl-2-propenone >=98.0% (GC)
  • Benzalacetophenone, 1,3-Diphenylprop-2-en-1-one
  • -2-propenone
  • (Z)-1,3-diphenylprop-2-en-1-one
  • AI3-00946
  • CCRIS 2213
  • NSC 26612
  • Chalcone &gt
  • Chalcone b
  • CHALCONE