ChemicalBook > CAS DataBase List > Fluorescein Sodium

Fluorescein Sodium

Product Name
Fluorescein Sodium
CAS No.
518-47-8
Chemical Name
Fluorescein Sodium
Synonyms
FLUORESCEIN SODIUM SALT;SODIUM FLUORESCEIN;CI 45350;ACID YELLOW 73;FLUORESCEIN DISODIUM SALT;URANINE;Fluorin;YELLOW 8;Fluorescite;aizenuranine
CBNumber
CB0753559
Molecular Formula
C20H13NaO5
Formula Weight
356.31
MOL File
518-47-8.mol
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Fluorescein Sodium Property

Melting point:
320 °C
Density 
0.579[at 20℃]
vapor pressure 
2.133hPa
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: soluble1mg/mL
form 
Powder
pka
2.2, 4.4, 6.7(at 25℃)
Colour Index 
45350
color 
Rust-orange
PH Range
Pink uorescence (4.0) to green uorescence (6.0)
PH
8.3 (10g/l, H2O, 20℃)
Odor
Odorless
Water Solubility 
500 g/L (20 ºC)
λmax
491nm, 493.5nm, 490nm
Merck 
14,4159
BRN 
3833041
Stability:
Stable.
Major Application
Nanolithography, nanoparticles, thin films, fuel cells, inks, laser, colored bubbles, cleansing products, identifying leaks in coolant, suntanning agent, hair dyes, cosmetics, dermatology, dental material, diagnosis of diabetic retinopathy, antitumor agent
InChIKey
NJDNXYGOVLYJHP-UHFFFAOYSA-L
LogP
0.34
CAS DataBase Reference
518-47-8(CAS DataBase Reference)
EPA Substance Registry System
Fluorescein, disodium salt (518-47-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
22-24/25-37/39-26-36/37/39-27
WGK Germany 
1
RTECS 
LM5425000
3
TSCA 
Yes
HS Code 
32041200
Hazardous Substances Data
518-47-8(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (mg/kg): 4738, 6721 orally (Yankel, Loux)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
46970
Product name
Fluorescein sodium salt
Purity
p.a., for source staining
Packaging
100g
Price
$47.2
Updated
2024/03/01
Sigma-Aldrich
Product number
46960
Product name
Fluorescein sodium salt
Purity
BioReagent, suitable for fluorescence
Packaging
25g
Price
$18.4
Updated
2024/03/01
Sigma-Aldrich
Product number
46970
Product name
Fluorescein sodium salt
Purity
p.a., for source staining
Packaging
500g
Price
$167
Updated
2024/03/01
Sigma-Aldrich
Product number
46960
Product name
Fluorescein sodium salt
Purity
BioReagent, suitable for fluorescence
Packaging
100g
Price
$47.7
Updated
2024/03/01
Sigma-Aldrich
Product number
46960
Product name
Fluorescein sodium salt
Purity
BioReagent, suitable for fluorescence
Packaging
500g
Price
$148
Updated
2024/03/01
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Fluorescein Sodium Chemical Properties,Usage,Production

Chemical Properties

Orange-red powder; odorless. Hygroscopic, soluble in water; sparingly soluble in alcohol.

Uses

Fluorescein sodium salt is a sodium salt of fluorescein. It can also be used in technical or engineered material use in-situ photochemical fabrication of transition metal-?promoted amorphous molybdenum sulfide catalysts for enhanced photosensitized hydrogen evolution. Dyes and metabolites, Environmental Testing

Uses

In examining subterranean waters. Serves to ascertain source of springs, connections between streams and sea, determining approx vol of water delivered by a spring, detecting source of contamination of drinking water, infiltration of soil with waste waters of factories. In externally applied drugs and cosmetics. Analytical reagent (protein label). Clinical reagent (immuno-histological stain, immuno-fluorescent label).

General Description

Fluorescein sodium is an orange-red to dark red powder. Water-soluble form of fluorescein. Odorless and almost tasteless. pH (5% solution) 7.8. May be sensitive to prolonged exposure to light and to heat.

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Fluorescein disodium salt is incompatible with strong oxidizers. Also incompatible with acids, acid salts and salts of heavy metals .

Fire Hazard

Flash point data for Fluorescein disodium salt are not available; however, Fluorescein disodium salt is probably combustible.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Human systemic effects by intravenous route: arrhythmias, eye hemorrhage, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.

Veterinary Drugs and Treatments

Fluorescein sodium is a yellow water-soluble dye that fluoresces under a Wood’s Lamp, but is plainly visible after binding to corneal stroma through an ophthalmic examination light source. It is used most commonly to delineate full thickness loss of corneal epithelium indicating the presence of a corneal ulceration. In this instance it will stain the corneal stroma. The epithelium is not stained because its outer lipid cell membrane repels the stain. Descemet’s membrane will not stain with fluorescein stain and this is used to indicate descemetocele formation, an ocular emergency.
Fluorescein stain is applied to the precorneal tear film in dogs and cats and the break-up of this stain with time, as observed through a slit lamp biomicroscope using a cobalt blue light source, is used to determine the tear film break-up time (normal 19 seconds), an indicator of tear film quality.
Fluorescein stain is applied to the tear film of dogs to determine patency of the nasolacrimal outflow system. The normal wait time is 2 – 5 minutes in dogs and up to 10 minutes in cats. A positive test indicates patency of the system. A negative test is not indicative of disease as the test is negative in a large percentage of normal animals. Fluorescein stain, then, can be added to irrigating solution to flush the nasolacrimal system, making detecting the irrigation solution at the nose more obvious during flushing of the system.

Properties and Applications

brilliant yellow. Soluble in water and ethanol (with strong green fluorescent), water-soluble good. In strong sulfuric acid with weak for fluorescence yellow, it will be diluted with yellow precipitation. Its water solution and sodium hydroxide with dark green fluorescence for brunet solution. Mainly used for sea of target that fluorescent, facilitate aerial reconnaissance search. And can use significantly for the exploration of fluorescent groundwater. Can also be used for medicine and cosmetics shading, rarely used for silk printing and dyeing things.

Fluorescein Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fluorescein Sodium manufacturers

Shenyang Simchoice Chemical Co.,Ltd
Product
Fluorescein Sodium 518-47-8
Min. Order
25KG
Purity
99%
Supply Ability
1000kgs per month
Release date
2020-08-09
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Fluorescein sodium 518-47-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99.91%
Supply Ability
200000
Release date
2024-04-25
Henan Fengda Chemical Co., Ltd
Product
Fluorescein Sodium 518-47-8
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

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