ChemicalBook > CAS DataBase List > 2-Fluoro-4-methylbenzoic acid
2-Fluoro-4-methylbenzoic acid
- Product Name
- 2-Fluoro-4-methylbenzoic acid
- CAS No.
- 7697-23-6
- Chemical Name
- 2-Fluoro-4-methylbenzoic acid
- Synonyms
- RARECHEM AL BO 2237;2-Fluoro-p-toluic Acid;4-Carboxy-3-fluorotoluene;2-Fluoro-4-methylbenzoicaci;2-FLUORO-4-METHYLBENZOIC ACID;2-Fluoro-4-methylbenzoicAcid>Benzoic acid, 2-fluoro-4-methyl-;4-Carboxy-3-fluorotoluene, 2-Fluoro-p-toluic acid
- CBNumber
- CB0754783
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 7697-23-6.mol
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2-Fluoro-4-methylbenzoic acid Property
- Melting point:
- 186-189°C
- Boiling point:
- 271.7±20.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3.44±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C8H7FO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)
- InChIKey
- ALFWHEYHCZRVLO-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(C)C=C1F
- CAS DataBase Reference
- 7697-23-6(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36-37
- HazardClass
- IRRITANT
- HS Code
- 29163990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- F0813
- Product name
- 2-Fluoro-4-methylbenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0813
- Product name
- 2-Fluoro-4-methylbenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $128
- Updated
- 2025/07/31
TRC
- Product number
- F596645
- Product name
- 2-Fluoro-4-methylbenzoic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2721-3-06
- Product name
- 2-Fluoro-4-methylbenzoic acid
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC5934
- Product name
- 2-Fluoro-4-methylbenzoic Acid
- Packaging
- 5g
- Price
- $19
- Updated
- 2021/12/16
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2-Fluoro-4-methylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Light yellow to dark yellow solid
Uses
2-Fluoro-4-methylbenzoic Acid is a useful reagent for preparing tubulin inhibitors for antitumor agents.
Synthesis
352-70-5
865-47-4
7697-23-6
Step A: 3-Fluorotoluene (Compound 1, 18.7 g, 170 mmol) was added to a 500 mL three-necked flask under nitrogen protection and cooled to -78 °C. Subsequently, a THF solution of potassium tert-butoxide (11.0 g, 170 mmol) was slowly added via syringe.After 10 min, a pentane solution of tert-butyllithium (19.0 g, 170 mmol) was slowly added via cannula. The reaction mixture was stirred at -78 °C for 2.5 hours. Upon completion of the reaction, the reaction was quenched with a large amount of crushed fresh dry ice, removed from the -78 °C bath and manually stirred with a metal spatula until the dark brown substance was transformed into a light yellow slurry. After 20 minutes of manual mixing, approximately 500 mL of water was added and the reaction mixture continued to be stirred. Subsequently, the reaction mixture was washed with ether (Et2O) and then acidified with 6N hydrochloric acid to pH less than 3 and extracted again with ether. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give compound 2 (10 g, 45% yield).1H NMR (400 MHz, CDCl3) δ 7.90 (t, 1H), 7.04 (d, 1H), 6.97 (d, 1H), 2.39 (s, 3H).
References
[1] Patent: US2004/176325, 2004, A1. Location in patent: Page/Page column 31; sheet 33
2-Fluoro-4-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-methylbenzoic acid manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 2-Fluoro-4-methylbenzoic acid 7697-23-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
Speranza Chemical Co., Ltd.
- Product
- 2-fluoro-4-methylbenzoic acid 7697-23-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100MT/Year
- Release date
- 2024-11-06
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Fluoro-4-methylbenzoic acid 7697-23-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
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