2-Fluoro-4-hydroxybenzaldehyde

Product Name: 2-Fluoro-4-hydroxybenzaldehyde
CAS No.: 348-27-6
Chemical Name: 2-Fluoro-4-hydroxybenzaldehyde
Synonyms: 3-Fluoro-4-formylphenol;2-Fluoro-6-nitroacetophenone;2-FLURO-4-HYDROXYBENZALDEHYDE;2-FLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-4-hydroxy-;2-Fluoro-4-hydroxybenzaldehyde,98%
CBNumber: CB2214861
Molecular Formula: C7H5FO2
Formula Weight: 140.11
MOL File: 348-27-6.mol

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2-Fluoro-4-hydroxybenzaldehyde Property

Melting point:: 168-170°C
Boiling point:: 254.2±20.0 °C(Predicted)
Density: 1.350±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystalline powder
pka: 6.78±0.18(Predicted)
color: Light tan
InChI: InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H
InChIKey: ONRPXRPUBXXCCM-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(O)C=C1F
CAS DataBase Reference: 348-27-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-37/38-41-52
Safety Statements: 26-39
Hazard Note: Irritant
HS Code: 2912490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H26218
Product name: 2-Fluoro-4-hydroxybenzaldehyde, 97%
Packaging: 100mg
Price: $99.65
Updated: 2024/03/01

Alfa Aesar

Product number: H26218
Product name: 2-Fluoro-4-hydroxybenzaldehyde, 97%
Packaging: 500mg
Price: $292.65
Updated: 2024/03/01

TRC

Product number: F597973
Product name: 2-Fluoro-4-hydroxybenzaldehyde
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 072823
Product name: 2-Fluoro-4-hydroxybenzaldehyde
Purity: 95+%
Packaging: 5g
Price: $69
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0019786
Product name: 2-FLUORO-4-HYDROXYBENZALDEHYDE
Purity: 95.00%
Packaging: 250MG
Price: $126
Updated: 2021/12/16

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2-Fluoro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production

Uses

2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

Uses

2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups.

Synthesis

Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting.

2-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-hydroxybenzaldehyde Suppliers

China 151 France 1 Germany 5 India 6 Italy 1 The Netherlands 1 United Kingdom 16 United States 31 Global 212

Hepharma Biology And Technology CO.,LTD.

Tel: 181-55150309 18155150309
Email: waimaobu@hepharma.cn
Country: China
ProdList: 2896
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2882
Advantage: 65

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35906
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9551
Advantage: 66

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View Lastest Price from 2-Fluoro-4-hydroxybenzaldehyde manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Fluoro-4-hydroxybenzaldehyde 348-27-6
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Hebei Mojin Biotechnology Co., Ltd

Product: 2-Fluoro-4-hydroxybenzaldehyde 348-27-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-07-27

Hebei Guanlang Biotechnology Co., Ltd.

Product: 2-Fluoro-4-hydroxybenzaldehyde 348-27-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2023-02-13

348-27-6, 2-Fluoro-4-hydroxybenzaldehydeRelated Search:

4-Hydroxybenzaldehyde Benzaldehyde Salicylaldehyde 3-(Trifluoromethyl)benzaldehyde 2-(Trifluoromethyl)benzaldehyde 3-Hydroxybenzaldehyde 2-Fluoro-4-hydroxybenzoic acid 2-Fluoro-4-methylbenzoic acid 3-FLUORO-4-HYDROXYBENZALDEHYDE Fluorine 2-Fluoro-4-methoxyacetophenone 2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid 2'-Fluoro-4'-hydroxyacetophenone 6-FLUOROVERATRALDEHYDE 3-FLUORO-2-HYDROXYBENZALDEHYDE,3-Fluoro-2-Hydroxybenzaldehyde 3-Fluoro Salicylaldehyde,3-Fluoro-2-hydroxybenzaldehyde ,99% 2-FLUORO-5-HYDROXYBENZALDEHYDE 5-Fluorosalicylaldehyde 3,5-Difluoro-4-hydroxybenzaldehyde

2-FLUORO-4-HYDROXYBENZALDEHYDE

2-FLURO-4-HYDROXYBENZALDEHYDE

2-Fluoro-4-hydroxybenzaldehyde,98%

3-Fluoro-4-formylphenol

Benzaldehyde, 2-fluoro-4-hydroxy-

2-Fluoro-6-nitroacetophenone

348-27-6

C7H5O2F

Aromatic Aldehydes & Derivatives (substituted)

API intermediates