2-FLUORO-5-HYDROXYBENZALDEHYDE
- Product Name
- 2-FLUORO-5-HYDROXYBENZALDEHYDE
- CAS No.
- 103438-84-2
- Chemical Name
- 2-FLUORO-5-HYDROXYBENZALDEHYDE
- Synonyms
- 2-FLUORO-5-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-5-hydroxy-;2-Fluoro-5-hydroxybenzaldehyde, 98%min
- CBNumber
- CB3802582
- Molecular Formula
- C7H5FO2
- Formula Weight
- 140.11
- MOL File
- 103438-84-2.mol
2-FLUORO-5-HYDROXYBENZALDEHYDE Property
- Melting point:
- 74-75 °C
- Boiling point:
- 257.6±20.0 °C(Predicted)
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.25±0.18(Predicted)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C7H5FO2/c8-7-2-1-6(10)3-5(7)4-9/h1-4,10H
- InChIKey
- SNILBNSNKISKLU-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(O)=CC=C1F
Safety
- HS Code
- 2912490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F591755
- Product name
- 2-Fluoro-5-hydroxybenzaldehyde
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 072319
- Product name
- 2-Fluoro-5-hydroxybenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- 076097
- Product name
- 2-Fluoro-5-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- PC49096
- Product name
- 2-Fluoro-5-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 076097
- Product name
- 2-Fluoro-5-hydroxybenzaldehyde
- Packaging
- 10g
- Price
- $225
- Updated
- 2021/12/16
2-FLUORO-5-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
2-Fluoro-5-hydroxybenzaldehyde is solid at room temperature and pressure, with weak acidity and good chemical reaction activity, it is difficult to dissolve in water but can be dissolved in common organic solvents, including ethyl acetate, dichloromethane and so on.
Uses
2-Fluoro-5-hydroxybenzaldehyde is used in the enantioselective synthesis of 1,?1''-?spirobiindane-?7,?7''-?diol (SPINOL) derivatives.
Synthesis
105728-90-3
103438-84-2
General procedure for the synthesis of 2-fluoro-5-hydroxybenzaldehyde from 2-fluoro-5-methoxybenzaldehyde: Step 1: BBr3 (4 mL, 4 mmol, 1.0 M solution in heptane) was slowly added dropwise to a dichloromethane solution of 2-fluoro-5-methoxybenzaldehyde at -78 °C. The reaction mixture was stirred continuously at -78 °C for 1 hour, followed by slow warming to 0 °C and continued stirring for 2 hours. Upon completion of the reaction, the mixture was poured into water and extracted with ethyl acetate (3 x 10 mL). The organic phases were combined, washed sequentially with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting residue was purified by silica gel column chromatography with 0-20% ethyl acetate-hexane mixed solvent as eluent, resulting in a white solid target product 2-fluoro-5-hydroxybenzaldehyde (142 mg, 25% yield). Mass spectrometry analysis showed m/z 141 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 3, p. 677 - 694
[2] Patent: WO2005/82890, 2005, A1. Location in patent: Page/Page column 69-70
[3] Patent: US2008/9533, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: WO2005/9940, 2005, A1. Location in patent: Page 183
[5] Patent: WO2013/61052, 2013, A1. Location in patent: Page/Page column 64
2-FLUORO-5-HYDROXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-5-HYDROXYBENZALDEHYDE manufacturers
- Product
- 2-FLUORO-5-HYDROXYBENZALDEHYDE 103438-84-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-09-18
- Product
- 2-FLUORO-5-HYDROXYBENZALDEHYDE 103438-84-2
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-14