5-Fluorosalicylaldehyde
- Product Name
- 5-Fluorosalicylaldehyde
- CAS No.
- 347-54-6
- Chemical Name
- 5-Fluorosalicylaldehyde
- Synonyms
- 5-FLUORO-2-HYDROXYBENZALDEHYDE;5-FLUOROSALICYLALDEHYDE;5-FluoroSalicylicAldehyde;5-Fluorosalicylaldehyde>5-Fluorosalicylaldehyde 97%;5-FLUORO-2-HYDROXYBENZALDEHY;5-Fluorosalicylaldehyde, 98+%;5-Fluorosalicylaldehyde, 97%,;Benzaldehyde, 5-fluoro-2-hydroxy-;5-Fluoro-2-hydroxybenzaldehyde,97%
- CBNumber
- CB7388152
- Molecular Formula
- C7H5FO2
- Formula Weight
- 140.11
- MOL File
- 347-54-6.mol
5-Fluorosalicylaldehyde Property
- Melting point:
- 82-85 °C (lit.)
- Boiling point:
- 56 °C / 1mmHg
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 8.18±0.18(Predicted)
- form
- Powder or Flakes
- color
- White to Orange to Green
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C7H5FO2/c8-6-1-2-7(10)5(3-6)4-9/h1-4,10H
- InChIKey
- FDUBQNUDZOGOFE-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(F)=CC=C1O
- CAS DataBase Reference
- 347-54-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 526274
- Product name
- 5-Fluorosalicylaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $82.6
- Updated
- 2025/07/31
- Product number
- F0574
- Product name
- 5-Fluorosalicylaldehyde
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- F0574
- Product name
- 5-Fluorosalicylaldehyde
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $206
- Updated
- 2025/07/31
- Product number
- F598075
- Product name
- 5-Fluoro-2-hydroxybenzaldehyde
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C229
- Product name
- 5-Fluoro-2-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
5-Fluorosalicylaldehyde Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
5-Fluorosalicylaldehyde may be used to synthesize:
- managanese (III) complex [MnLa(μ1,3-N3)]n [H2La = N,N′-bis(5-fluorosalicylidene)-1,2-diaminoethane]
- enantiopure 4-amino-6-fluoro-3-(hydroxymethyl)chromanes
- 4,4′-difluoro-2,2′-[(hydrazine-1,2-diylidene)bis(methanylylidene)]-diphenol
- N,N′-bis(5-fluoro-2-hydroxybenzylidene)ethylenediamine
- N,N′-(2-hydroxypropane-1,3-diyl)-bis(salicylaldimine (H2L)
General Description
5-Fluorosalicylaldehyde can be synthesized from 4-fluorophenol.
Synthesis
371-41-5
67-66-3
347-54-6
The general procedure for the synthesis of 5-fluorosalicylaldehyde from 4-fluorophenol and trichloromethane is as follows: Step A: To a solution of water (400mL) containing NaOH (78g, 1950mmol) was added a mixture of 4-fluorophenol (50g, 446.43mmol) in water (200mL) and ethanol (150mL). After heating the mixture to 70°C, trichloromethane (110 mL) was slowly added dropwise through the addition funnel (approximately 2 hours to complete the drop) and the reaction mixture was continuously stirred at this temperature overnight (approximately 16 hours). Upon completion of the reaction, the mixture was cooled to room temperature and acidified with 3M HCl solution. Subsequently, the reaction mixture was partitioned between saturated saline and dichloromethane, the organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluent: 3% ethyl acetate/hexane) to afford 13.6 g of 5-fluorosalicylaldehyde (22% yield, white solid).
References
[1] Journal of the American Chemical Society, 1998, vol. 120, # 33, p. 8340 - 8347
[2] Patent: WO2005/37763, 2005, A1. Location in patent: Page/Page column 126
[3] Patent: US2017/37038, 2017, A1. Location in patent: Paragraph 0372; 0373; 0374
[4] Journal of the American Chemical Society, 1946, vol. 68, p. 2502
[5] European Journal of Medicinal Chemistry, 1996, vol. 31, # 6, p. 449 - 460
5-Fluorosalicylaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluorosalicylaldehyde manufacturers
- Product
- 5-Fluorosalicylaldehyde 347-54-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-11-15
- Product
- 5-Fluoro-2-hydroxybenzaldehyde 347-54-6
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-10-08
- Product
- 5-Fluorosalicylaldehyde 347-54-6
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-10-17