4-FLUORO-2-HYDROXYBENZALDEHYDE

Product Name: 4-FLUORO-2-HYDROXYBENZALDEHYDE
CAS No.: 348-28-7
Chemical Name: 4-FLUORO-2-HYDROXYBENZALDEHYDE
Synonyms: 4-FLUOROSALICYLALDEHYDE;SW-40;SWF-40;4-Fluorosalicyladehyde;4-FLUORO-2-HYDROXYBENZALDEHYDE;2-HYDROXY-4-FLUOROBENZALDEHYDE;Benzaldehyde, 4-fluoro-2-hydroxy-;4-Fluoro-2-hydroxybenzaldehyde ,98%;4-Fluorosalicylaldehyde, 5-Fluoro-2-formylphenol;2-Hydroxy-4-Fluorobenzaldehyde 4-Fluoro Salicylaldehyde
CBNumber: CB2437912
Molecular Formula: C7H5FO2
Formula Weight: 140.11
MOL File: 348-28-7.mol

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4-FLUORO-2-HYDROXYBENZALDEHYDE Property

Melting point:: 70-72°C
Boiling point:: 208.2±20.0 °C(Predicted)
Density: 1.350±0.06 g/cm3(Predicted)
Flash point:: 110°
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystalline solid
pka: 7.18±0.10(Predicted)
color: Pale yellow
Sensitive: Air Sensitive
CAS DataBase Reference: 348-28-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37
Hazard Note: Irritant
HS Code: 29122990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: F596205
Product name: 4-Fluorosalicylaldehyde
Packaging: 1g
Price: $40
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2620-3-42
Product name: 4-Fluoro-2-hydroxybenzaldehyde
Purity: 99%
Packaging: 1g
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2620-3-42
Product name: 4-Fluoro-2-hydroxybenzaldehyde
Purity: 99%
Packaging: 5G
Price: $98
Updated: 2021/12/16

Matrix Scientific

Product number: 072824
Product name: 4-Fluorosalicylaldehyde
Purity: 95+%
Packaging: 5g
Price: $160
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK540611
Product name: 4-Fluoro-2-hydroxybenzaldehyde
Purity: 95%
Packaging: 1g
Price: $222
Updated: 2021/12/16

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4-FLUORO-2-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

4-Fluorosalicylaldehyde is used as a reagent to synthesize quinoline derivatives that have potential antibacterial and antituberculosis effects. 4-Fluorosalicylaldehyde is also used as a reagent to prepare chromones (e.g. 4-Oxo-4H-1-benzopyran-2-carboxylic acid [B205670]).

Synthesis

50-00-0

372-20-3

348-28-7

The general procedure for the synthesis of 4-fluoro-2-hydroxybenzaldehyde from formaldehyde and 3-fluorophenol was as follows: to a mixture containing 3-fluorophenol (5 mL, 55.3 mmol) and anhydrous acetonitrile (250 mL) were added MgCl2 (14.2 g, 149 mmol), anhydrous trimethylamine (27 mL) and paraformaldehyde (11 g). The reaction mixture was stirred under reflux conditions for 5 h and subsequently cooled to room temperature. The reaction was quenched by addition of 5% hydrochloric acid (250 mL) and extracted with ethyl acetate (100 mL × 3). The combined organic layers were washed sequentially with 5% hydrochloric acid, water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 50:1 to 20:1) to afford 4-fluoro-2-hydroxybenzaldehyde (5 g, 65% yield) as a light yellow solid.1H NMR (400 MHz, CDCl3) data were as follows: δ 11.37 (d, J = 1.6 Hz, 1H), 9.83 (s, 1H), 7.55- 7.59 (m, 1H), 6.65-6.75 (m, 2H).

References

[1] Patent: WO2004/87686, 2004, A2. Location in patent: Page 504
[2] Patent: WO2004/87687, 2004, A1. Location in patent: Page 504
[3] Patent: WO2017/55860, 2017, A1. Location in patent: Page/Page column 138-139
[4] Patent: US2017/37038, 2017, A1. Location in patent: Paragraph 0375; 0376; 0377
[5] Patent: KR101679262, 2016, B1. Location in patent: Paragraph 0156-0158

4-FLUORO-2-HYDROXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FLUORO-2-HYDROXYBENZALDEHYDE Suppliers

China 178 Europe 2 Germany 3 India 4 Italy 1 United Kingdom 12 United States 22 Global 222

J & K SCIENTIFIC LTD.

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View Lastest Price from 4-FLUORO-2-HYDROXYBENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-FLUORO-2-HYDROXYBENZALDEHYDE 348-28-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-25

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Fluoro-2-hydroxybenzaldehyde 348-28-7
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Career Henan Chemical Co

Product: 4-FLUORO-2-HYDROXYBENZALDEHYDE 348-28-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

348-28-7, 4-FLUORO-2-HYDROXYBENZALDEHYDERelated Search:

tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride No Chinese name rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE 1-METHYL-5-NITRO-1H-INDAZOLE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Pyrrolidine-3-carboxaMide hydrochloride 5-Bromoindazole (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate 2-cyclopylcyclopropane-1-carboxylic acid 4-CYANO-7-AZAINDOLE 5-Bromoindole (+/-)-BOC-ALPHA-PHOSPHONOGLYCINE TRIMETHYL ESTER 1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine 4-CYANOPYRAZOLE

2-HYDROXY-4-FLUOROBENZALDEHYDE

4-FLUORO-2-HYDROXYBENZALDEHYDE

4-FLUOROSALICYLALDEHYDE

2-Hydroxy-4-Fluorobenzaldehyde 4-Fluoro Salicylaldehyde

4-FLUOROSALICYLALDEHYDE (4-FLUORO-2-HYDROXYBENZALDEHYDE)

4-Fluoro-2-hydroxybenzaldehyde ,98%

4-Fluorosalicyladehyde

4-Fluorosalicylaldehyde, 5-Fluoro-2-formylphenol

Benzaldehyde, 4-fluoro-2-hydroxy-

SWF-40

SW-40

348-28-7

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde