2-FLUORO-6-HYDROXYBENZALDEHYDE
- Product Name
- 2-FLUORO-6-HYDROXYBENZALDEHYDE
- CAS No.
- 38226-10-7
- Chemical Name
- 2-FLUORO-6-HYDROXYBENZALDEHYDE
- Synonyms
- 6-FLUOROSALICYLALDEHYDE;6-Fluorosalicylaldehyde>6-Fluorosalicylaldehyde,97%;4-Fluoro-4-nitroacetophneone;2-Fluor-6-Hydroxybenzaldehyde;2-FLUORO-6-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-6-hydroxy-;2-Fluoro-6-hydroxybenzaldehyde 98%;6-Fluorosalicylaldehyde, 3-Fluoro-2-formylphenol
- CBNumber
- CB4306380
- Molecular Formula
- C7H5FO2
- Formula Weight
- 140.11
- MOL File
- 38226-10-7.mol
2-FLUORO-6-HYDROXYBENZALDEHYDE Property
- Melting point:
- 37-39°C
- Boiling point:
- 201.3±20.0 °C(Predicted)
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to lump
- pka
- 7.18±0.10(Predicted)
- color
- White to Yellow to Orange
- Sensitive
- Air Sensitive
- BRN
- 1935289
- InChI
- InChI=1S/C7H5FO2/c8-6-2-1-3-7(10)5(6)4-9/h1-4,10H
- InChIKey
- FZIBGCDUHZBOLA-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C(O)C=CC=C1F
- CAS DataBase Reference
- 38226-10-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-36/37/39-27
- Hazard Note
- Irritant
- HS Code
- 2912490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0988
- Product name
- 6-Fluorosalicylaldehyde
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $142
- Updated
- 2025/07/31
- Product number
- F0988
- Product name
- 6-Fluorosalicylaldehyde
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $503
- Updated
- 2025/07/31
- Product number
- F595905
- Product name
- 6-Fluorosalicylaldehyde
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 012410
- Product name
- 6-Fluorosalicylaldehyde
- Packaging
- 100mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- W5897
- Product name
- 2-Fluoro-6-hydroxybenzaldehyde
- Packaging
- 25g
- Price
- $295
- Updated
- 2021/12/16
2-FLUORO-6-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-FLUORO-6-HYDROXYBENZALDEHYDE is used in the preparation of aromatic compounds as human PAI-1 inhibitors.
Synthesis
199388-02-8
38226-10-7
Step 3: Synthesis of 2-fluoro-6-hydroxybenzaldehyde A solution of 2-fluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde (6.5 g, 29.0 mmol) and p-toluenesulfonic acid (TsOH, 2 g, 11.6 mmol) in dichloromethane (DCM, 30 mL) was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was diluted with dichloromethane (100 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 100:1 to 20:1 gradient elution) to afford 2-fluoro-6-hydroxybenzaldehyde (3.0 g, 74% yield) as a light yellow solid. 1H NMR (400 MHz, CDCl3): δ 11.49 (s, 1H), 10.29 (s, 1H), 7.46-7.52 (m, 1H), 6.79 (d, J = 8.8 Hz, 1H), 6.63-6.68 (m, 1H).
References
[1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 19, p. 2925 - 2929
[2] Patent: US2017/37038, 2017, A1. Location in patent: Paragraph 0096; 0378; 0382; 0383
2-FLUORO-6-HYDROXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-6-HYDROXYBENZALDEHYDE manufacturers
- Product
- 2-FLUORO-6-HYDROXYBENZALDEHYDE 38226-10-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19