Diacerein

Immunosuppressive drugs Uses

Product Name: Diacerein
CAS No.: 13739-02-1
Chemical Name: Diacerein
Synonyms: DAR;Diacereine;SF 277;artrodar;Fisiodar;ICN17261;DIACEREIN;ICN 17261;ICN-17261;Diacetine
CBNumber: CB0755179
Molecular Formula: C19H12O8
Formula Weight: 368.29
MOL File: 13739-02-1.mol

More

Less

Diacerein Property

Melting point:: 217-2180C
Boiling point:: 631.5±55.0 °C(Predicted)
Density: 1.491±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 3.01±0.20(Predicted)
color: Light Yellow to Yellow
Water Solubility: 240μg/L at 25℃
Merck: 14,2960
InChIKey: TYNLGDBUJLVSMA-UHFFFAOYSA-N
LogP: 3.126 (est)
CAS DataBase Reference: 13739-02-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: CB8781000
HS Code: 29146990
Toxicity: rat,LD50,unreported,7500mg/kg (7500mg/kg),Drugs of the Future. Vol. 4, Pg. 445, 1979.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001595
Product name: Diacerein
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001595
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: D9302
Product name: Diacerein
Purity: ≥95% (HPLC)
Packaging: 50mg
Price: $85.6
Updated: 2024/03/01

TCI Chemical

Product number: D4061
Product name: Diacerein
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $101
Updated: 2024/03/01

TCI Chemical

Product number: D4061
Product name: Diacerein
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $261
Updated: 2024/03/01

Alfa Aesar

Product number: J63775
Product name: Diacerein
Packaging: 1g
Price: $167.65
Updated: 2024/03/01

More

Less

Diacerein Chemical Properties,Usage,Production

Immunosuppressive drugs

Diacerein is a novel interleukin (IL)-1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect.
Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform.
Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include:
1, inhibit the IL-1 synthesis of synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes .
3, inhibition of IL-1 activity.
4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide.
5, promote the synthesis of collagen and glycosaminoglycan.
6, inhibit the leukocyte chemotaxis and lysosomal stability.
Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate.
Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg/L, AUC is 21.3 mg • h/L, T1/2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food .
Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools.
The above information is edited by the chemicalbook of Tian Ye.

Uses

It is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance.
This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis.
It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.

Description

Diacerein is a disease-modifying antirheumatic drug (DMARD), reported to be useful in the treatment of various inflammatory conditions, including osteoarthritis. It forms water soluble chelates with calcium and copper, acting ultimately to reduce the activity of lysosomal enzymes and decrease the formation of rheumatoid factor.

Chemical Properties

Yellow Crystalline Solid

Originator

Proter (Italy)

Uses

A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic

Uses

antiinflammatory

Uses

A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.

Uses

Treatment of Osteoarthritis (Prevent cartilage destruction)

Uses

Diacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.

Definition

ChEBI: 4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid is an anthraquinone.

brand name

ARTRODAR

Diacerein Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Diacerein Suppliers

Americas 1 Brazil 3 Canada 3 China 370 Czech Republic 1 Egypt 1 Europe 3 France 1 Germany 4 Greece 1 India 91 Italy 7 Japan 1 Malaysia 1 Mexico 1 Nepal 1 Philippines 1 South Korea 1 Spain 2 Switzerland 3 United Kingdom 9 United States 39 USA 1 Global 546

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

CarboMer, Inc.

Tel: --
Fax: --
Email: sales@carbomer.com
Country: United States
ProdList: 4026
Advantage: 67

Focus Synthesis LLC

Tel: --
Fax: --
Email: acd@focussynthesis.com
Country: United States
ProdList: 2487
Advantage: 61

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Selleck Chemicals LLC

Tel: --
Fax: --
Email: sales@selleckchem.com
Country: United States
ProdList: 1848
Advantage: 58

NetQem

Tel: --
Fax: --
Email: sales@netqem.us
Country: United States
ProdList: 1641
Advantage: 38

Ivy Fine Chemicals

Tel: --
Fax: --
Email: sales@ivychem.com
Country: United States
ProdList: 6493
Advantage: 58

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

HBCChem Inc.

Tel: --
Fax: --
Email: sales@hbcchem-inc.com
Country: United States
ProdList: 4569
Advantage: 30

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

Molcan Corporation

Tel: --
Fax: --
Email: info@molcan.com
Country: United States
ProdList: 686
Advantage: 60

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

Chembargains

Tel: --
Fax: --
Email: info@chembargains.com
Country: United States
ProdList: 178
Advantage: 69

Fine Chem Trading LTD

Tel: --
Fax: --
Email: chemfinder@chemfinder.co.uk
Country: United States
ProdList: 1609
Advantage: 64

ChromaDex

Tel: --
Fax: --
Email: sales@chromadex.com
Country: United States
ProdList: 2501
Advantage: 76

More

Less

View Lastest Price from Diacerein manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Diacerein 13739-02-1
Price: US $500.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2021-06-07

BINBO BIOLOGICAL CO.,LTD

Product: Diacerein 13739-02-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: >98%
Supply Ability: 1000 kg
Release date: 2024-04-25

Hebei Weibang Biotechnology Co., Ltd

Product: Diacerein 13739-02-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-31

13739-02-1, DiacereinRelated Search:

Meloxicam 4-Acetylbenzoic acid Aloe emodin 4-ETHYL-3-HYDROXYBENZOIC ACID Chrysophanic acid 3'-Acetoxyacetophenone 3-ACETOXYBENZOIC ACID Diacerein ANTHRAQUINONE-2-CARBOXYLIC ACID 4-FORMYL-3-HYDROXYBENZOIC ACID 1-methoxyanthraquinone 3-Methoxy-4-methylbenzoic acid 3-Hydroxy-4-methylbenzoic acid Rhein 2-ANTHRACENECARBOXYLIC ACID 3-METHOXY-3'-METHYLBENZOPHENONE 2-ACETOXYBENZOPHENONE 3-ACETOXY-3'-METHOXYBENZOPHENONE

1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE

DIACEREIN

DIACERHEIN

DIACETYL RHEIN

9,10-dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylicacid

9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicaciddiacetate

9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroicacidiacetate

artrodar

rhein,diacetate

4,5-Bis(acetyloxy)-9,10-dioxo-2-anthracenecarboxylic acid

4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic Acid

Diacereine

Diacerein, ≥95%（HPLC)

4,5-diacetyloxy-9,10-dioxo-2-anthracenecarboxylic acid

Diacerein 13739-02-1

1,8-diacetoxyanthraquinone-3-carboxylicacid

4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylicaci

4,5-diacetylrhein

4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid

4,5-Diacetoxy-9,10-dioxo-2-anthracenecarboxylic acid

4,5-diacetoxy-9,10-diketo-anthracene-2-carboxylic acid

4,5-diacetyloxy-9,10-dioxo-anthracene-2-carboxylic acid

4,5-diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid

Diacerein (1,8-Diacetoxy-3-carboxyanthraquinone)

4,5-Diacetoxyanthraquinone-2-carboxylic Acid

DAR

Fisiodar

SF 277

4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

DIACETYL RHEIN(P)

DIACERHEIN;DIACETYLRHEIN;FISIODAR;ARTRODAR

Diacerein CRS

Diacerein&gt

Diacerein impurity mixture CRS

2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-

Diacerein for Arthritis Treatment

Diacerein USP/EP/BP

Diacerein (Diacerhein)

Diacerein(Y0001595)

DiacereinQ: What is Diacerein Q: What is the CAS Number of Diacerein Q: What is the storage condition of Diacerein Q: What are the applications of Diacerein

Diacerein API

ICN 17261

ICN17261

ICN-17261

Diacerein, ≥ 98.0%

Diacerhein|||Fisiodar|||Diacetylrhein

Diacerein IP/EP

Diacetine

13739-02-1

C19H12O8

Analytical Standards

Analytical Chromatography Product Catalog

Drug Standards

Chromatography

Forensic and Veterinary Standards

Miscellaneous Biochemicals

Aromatics Compounds

Aromatics