ChemicalBook > CAS DataBase List > Ethyl 5-cyanoindole-2-carboxylate

Ethyl 5-cyanoindole-2-carboxylate

Product Name
Ethyl 5-cyanoindole-2-carboxylate
CAS No.
105191-13-7
Chemical Name
Ethyl 5-cyanoindole-2-carboxylate
Synonyms
Ethyl 5-cyanoindole-2-carboxylate;Ethyl 5-cyano-1H-indol-2-carboxylate;ETHYL 5-CYANO-1H-INDOLE-2-CARBOXYLATE;Methyl 5-cyano-1H-indole-2-carboxylate;5-CYANOINDOLE-2-CARBOXYLIC ACID ETHYL ESTER;5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;5-cyano-1H-indole-2-carboxylic acid methyl ester;1H-Indole-2-carboxylic acid, 5-cyano-, ethyl ester;5-cyano-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI);2-Hydroxy-4-methyl-6-oxo-1,6-dihydro-3-pyridinecarbonitrile
CBNumber
CB0756873
Molecular Formula
C12H10N2O2
Formula Weight
214.22
MOL File
105191-13-7.mol
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Ethyl 5-cyanoindole-2-carboxylate Property

Boiling point:
419.3±25.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
13.63±0.30(Predicted)
Appearance
Off-white to light brown Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
E938105
Product name
Ethyl5-Cyanoindole-2-carboxylate
Packaging
100mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC56769
Product name
5-Cyanoindole-2-carboxylic acid ethyl ester
Packaging
100mg
Price
$82
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC56769
Product name
5-Cyanoindole-2-carboxylic acid ethyl ester
Packaging
250mg
Price
$97.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC56769
Product name
5-Cyanoindole-2-carboxylic acid ethyl ester
Packaging
500mg
Price
$155
Updated
2021/12/16
AK Scientific
Product number
X8742
Product name
Ethyl5-cyanoindole-2-carboxylate
Packaging
1g
Price
$192
Updated
2021/12/16
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Ethyl 5-cyanoindole-2-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 5-cyanoindole-2-carboxylate is an important chemical raw material for the preparation of pril drugs and dye products, and is also widely used in the pharmaceutical industry.

Synthesis

16732-70-0

544-92-3

105191-13-7

General procedure for the synthesis of ethyl 5-cyano-1H-indole-2-carboxylate: a suspension of cuprous cyanide (27 mg, 0.3 mmol) and ethyl 5-bromoindole-2-carboxylate (138) in 500 μL of DMF was stirred and reacted for 7 hours at 155 °C. After completion of the reaction, it was purified by silica gel column chromatography (3 × 15 cm, SiO?, 20% EtOAc/hexane as eluent) to afford the target product, ethyl 5-cyano-1H-indole-2-carboxylate (139) (34 mg, 63% yield), as a white solid with melting point of 181-182 °C.

References

[1] Patent: US2005/26987, 2005, A1. Location in patent: Page 23

Ethyl 5-cyanoindole-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 5-cyanoindole-2-carboxylate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl 5-cyanoindole-2-carboxylate 105191-13-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl 5-cyanoindole-2-carboxylate 105191-13-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Ethyl 5-cyanoindole-2-carboxylate 105191-13-7
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-09

105191-13-7, Ethyl 5-cyanoindole-2-carboxylateRelated Search:

Indole-3-acetic acid Ethanol Ethyl acetate Ethyl N-cyanoethanimideate Indole-2-carboxylic acid Ethylparaben Trinexapac-ethyl Tris(trimethylsilyl)phosphate Indole-3-butyric acid RESMETHRIN Ethyl cyanoacetate Indole ETHYL 2-CYANOACRYLATE Ethyl formate ISOXADIFEN-ETHYL Indometacin 2-Ethoxyethanol Diethyl ether

  • Ethyl 5-cyanoindole-2-carboxylate
  • Methyl 5-cyano-1H-indole-2-carboxylate
  • 1H-Indole-2-carboxylic acid, 5-cyano-, ethyl ester
  • ETHYL 5-CYANO-1H-INDOLE-2-CARBOXYLATE
  • 5-CYANOINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
  • 5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
  • 5-cyano-1H-indole-2-carboxylic acid methyl ester
  • 2-Hydroxy-4-methyl-6-oxo-1,6-dihydro-3-pyridinecarbonitrile
  • 1H-Indole-2-carboxylic acid, 5-cyano-, ethyl ester (9CI, ACI)
  • 5-cyano-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI)
  • Ethyl 5-cyano-1H-indol-2-carboxylate
  • 105191-13-7