Ethyl 5-cyanoindole-2-carboxylate
- Product Name
- Ethyl 5-cyanoindole-2-carboxylate
- CAS No.
- 105191-13-7
- Chemical Name
- Ethyl 5-cyanoindole-2-carboxylate
- Synonyms
- Ethyl 5-cyanoindole-2-carboxylate;Ethyl 5-cyano-1H-indol-2-carboxylate;ETHYL 5-CYANO-1H-INDOLE-2-CARBOXYLATE;Methyl 5-cyano-1H-indole-2-carboxylate;5-CYANOINDOLE-2-CARBOXYLIC ACID ETHYL ESTER;5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;5-cyano-1H-indole-2-carboxylic acid methyl ester;1H-Indole-2-carboxylic acid, 5-cyano-, ethyl ester;5-cyano-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI);2-Hydroxy-4-methyl-6-oxo-1,6-dihydro-3-pyridinecarbonitrile
- CBNumber
- CB0756873
- Molecular Formula
- C12H10N2O2
- Formula Weight
- 214.22
- MOL File
- 105191-13-7.mol
Ethyl 5-cyanoindole-2-carboxylate Property
- Boiling point:
- 419.3±25.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.63±0.30(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- E938105
- Product name
- Ethyl5-Cyanoindole-2-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC56769
- Product name
- 5-Cyanoindole-2-carboxylic acid ethyl ester
- Packaging
- 100mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- FC56769
- Product name
- 5-Cyanoindole-2-carboxylic acid ethyl ester
- Packaging
- 250mg
- Price
- $97.5
- Updated
- 2021/12/16
- Product number
- FC56769
- Product name
- 5-Cyanoindole-2-carboxylic acid ethyl ester
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- X8742
- Product name
- Ethyl5-cyanoindole-2-carboxylate
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
Ethyl 5-cyanoindole-2-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 5-cyanoindole-2-carboxylate is an important chemical raw material for the preparation of pril drugs and dye products, and is also widely used in the pharmaceutical industry.
Synthesis
16732-70-0
544-92-3
105191-13-7
General procedure for the synthesis of ethyl 5-cyano-1H-indole-2-carboxylate: a suspension of cuprous cyanide (27 mg, 0.3 mmol) and ethyl 5-bromoindole-2-carboxylate (138) in 500 μL of DMF was stirred and reacted for 7 hours at 155 °C. After completion of the reaction, it was purified by silica gel column chromatography (3 × 15 cm, SiO?, 20% EtOAc/hexane as eluent) to afford the target product, ethyl 5-cyano-1H-indole-2-carboxylate (139) (34 mg, 63% yield), as a white solid with melting point of 181-182 °C.
References
[1] Patent: US2005/26987, 2005, A1. Location in patent: Page 23
Ethyl 5-cyanoindole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 5-cyanoindole-2-carboxylate Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from Ethyl 5-cyanoindole-2-carboxylate manufacturers
- Product
- Ethyl 5-cyanoindole-2-carboxylate 105191-13-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Ethyl 5-cyanoindole-2-carboxylate 105191-13-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Ethyl 5-cyanoindole-2-carboxylate 105191-13-7
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-09