4-Hydroxycoumarin
- Product Name
- 4-Hydroxycoumarin
- CAS No.
- 1076-38-6
- Chemical Name
- 4-Hydroxycoumarin
- Synonyms
- 4-HYDROXY-2H-CHROMEN-2-ONE;HydroxyCoumarin;4-Coumaryl alcohol;4-hydroxy-2h-1-benzopyran-2-on;COUMARINOL;4-HYDROXY-2H-1-BENZOPYRAN-2-ONE;4-Coumarinol;COUMARIN KIT;4-HydroxycouMa;4-HYDROXYCUMARIN
- CBNumber
- CB0760607
- Molecular Formula
- C9H6O3
- Formula Weight
- 162.14
- MOL File
- 1076-38-6.mol
4-Hydroxycoumarin Property
- Melting point:
- 211-213 °C (lit.)
- Boiling point:
- 228.82°C (rough estimate)
- Density
- 1.1734 (rough estimate)
- vapor pressure
- 0.02Pa at 25℃
- refractive index
- 1.4500 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.50±1.00(Predicted)
- form
- Liquid
- color
- Clear colorless to slightly yellow
- Odor
- Very faint woody-medicinal odor with a with Aluminum chloride. nut-like, hcrbaccous tone
- Water Solubility
- PRACTICALLY INSOLUBLE
- BRN
- 129768
- InChIKey
- VXIXUWQIVKSKSA-UHFFFAOYSA-N
- LogP
- 1.6-2.31 at 21.2℃
- CAS DataBase Reference
- 1076-38-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Hydroxycoumarin(1076-38-6)
- EPA Substance Registry System
- 2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- DJ3100000
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29322980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H23805
- Product name
- 4-Hydroxycoumarin
- Purity
- 98%
- Packaging
- 100g
- Price
- $67.6
- Updated
- 2024/03/01
- Product number
- H23805
- Product name
- 4-Hydroxycoumarin
- Purity
- 98%
- Packaging
- 500g
- Price
- $79.6
- Updated
- 2024/03/01
- Product number
- 40863
- Product name
- 4-Hydroxycoumarin
- Purity
- analytical standard
- Packaging
- 100MG
- Price
- $69.1
- Updated
- 2024/03/01
- Product number
- H0235
- Product name
- 4-Hydroxycoumarin
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $37
- Updated
- 2024/03/01
- Product number
- H0235
- Product name
- 4-Hydroxycoumarin
- Purity
- >98.0%(GC)(T)
- Packaging
- 250g
- Price
- $266
- Updated
- 2024/03/01
4-Hydroxycoumarin Chemical Properties,Usage,Production
Chemical Properties
Yellow powder or chunks or Slightly yellow needle-like crystals. freely soluble in ethanol, ether and hot water. brown in color with ferric chloride.
Uses
4-Hydroxycoumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase. 4-Hydroxycoumarins are a very important class of biologically active drugs which are widely used as anticoagulants-Warfarin and Acenocoumarol.
Uses
4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.
Uses
4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes.
Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium(III) chloride hydrate as a versatile homogeneous catalyst.
Definition
ChEBI: 4-hydroxycoumarin is a hydroxycoumarin that is coumarin in which the hydrogen at position 4 is replaced by a hydroxy group. It is a conjugate acid of a 4-hydroxycoumarin(1-).
Synthesis Reference(s)
The Journal of Organic Chemistry, 25, p. 677, 1960 DOI: 10.1021/jo01074a630
Flammability and Explosibility
Not classified
Synthesis
4-Hydroxycoumarin is prepared by the reaction of o-hydroxyacetophenone and Diethyl carbonate. The steps are as follows:
General procedure: To a stirred mixture (1.15 mmol) and sodium hydride (138 mg, 5.75 mmol) in 5 ml dry toluene, a solution of the diethyl carbonate (1.15 mmol) in dry toluene was dropped. The mixture was reacted at 0°C for 30 min, then heated to reflux and reacted for another 4 h. The reaction mixture was quenched with water (20 mL) at ice bath and neutralized to pH 7 with 2 N HCl. The precipitate was filtered, washed with cold water and dried to get 6a-f. 1.2.1.1. 4-Hydroxy-2H-chromen-2-one (6a) White solidyield: 95; 1H NMR (600 MHz, DMSO-d6) δ 12.53 (s, 1H), 7.83 (d, J = 7.2 Hz, 1H), 7.65 (d, J = 7.8 Hz, 1H), 7.38-7.34 (m, 2H), 5.60 (s, 1H).
Purification Methods
Crystallise 4-hydroxycoumarin from water and dry it in a vacuum desiccator over pKEst Sicapent. [Beilstein 18/1 V 378.]
4-Hydroxycoumarin Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxycoumarin Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
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- 23671
- Advantage
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- Fax
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- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
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- Sales@kemikalieimport.dk
- Country
- Europe
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View Lastest Price from 4-Hydroxycoumarin manufacturers
- Product
- 4-Hydroxycoumarin 1076-38-6
- Price
- US $100.00-75.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-20
- Product
- 4-Hydroxycoumarin 1076-38-6
- Price
- US $180.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-30
- Product
- 4-Hydroxycoumarin 1076-38-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min HPLC
- Supply Ability
- 10kgs
- Release date
- 2021-08-18