Methylbutyric acid Property

Melting point:

-70°C

Boiling point:

176-177 °C(lit.)

Density 

0.936 g/mL at 25 °C(lit.)

vapor pressure 

0.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.405(lit.)

FEMA 

2695 | 2-METHYLBUTYRIC ACID

Flash point:

165 °F

pka

4.8(at 25℃)

CAS DataBase Reference

600-07-7(CAS DataBase Reference)

NIST Chemistry Reference

2-Methylbutyric acid(600-07-7)

EPA Substance Registry System

Butanoic acid, 2-methyl-(600-07-7)

Safety

Hazard Codes 

C

Risk Statements 

21/22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 3

WGK Germany 

1

RTECS 

EK7897000

F 

13

HazardClass 

8

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P404Store in a closed container.

P405Store locked up.

P501Dispose of contents/container to..…

Methylbutyric acid Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid. The boiling point is 177°C, 84°C (2.8kPa), the relative density (20/17°C) is 0.938, and the refractive index (nD20) is 1.4055. Soluble in water, ethanol, ether.

Uses

Methylbutyric acid can be used as an organic synthesis intermediate.

Definition

ChEBI: 2-methylbutyric acid is a methylbutyric acid comprising a butyric acid core carrying a 2-methyl substituent. Produced from amino acid leucine during nutrient starvation in bacteria. It has a role as a bacterial metabolite and a human metabolite. It is a conjugate acid of a 2-methylbutyrate.

Synthesis

2-Chlorobutane is made into Grignard reagent, which is then reacted with carbon dioxide, and the reaction mixture is hydrolyzed with 25% sulfuric acid to generate Methylbutyric acid. Yield 76-86%.