ChemicalBook > CAS DataBase List > 3-ACETYL-2-CHLOROPYRIDINE

3-ACETYL-2-CHLOROPYRIDINE

Product Name: 3-ACETYL-2-CHLOROPYRIDINE
CAS No.: 55676-21-6
Chemical Name: 3-ACETYL-2-CHLOROPYRIDINE
Synonyms: 2-chloro-3-acetylpyridine;3-ACETYL-2-CHLOROPYRIDINE;3-Acetyl-2-chloropyridine 95%;3-Acetyl-2-chloropyridine >1-(2-chloro-3-pyridinyl)ethanone;1-(2-CHLOROPYRIDIN-3-YL)ETHANONE;Ethanone, 1-(2-chloro-3-pyridinyl)-;1-(2-chloro-3-pyridinyl)-1-ethanone;1-(2-chloropyridin-3-yl)ethan-1-one;1-(2-Chloropyridin-3-yl)-1-ethanone
CBNumber: CB0781372
Molecular Formula: C7H6ClNO
Formula Weight: 155.58
MOL File: 55676-21-6.mol

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3-ACETYL-2-CHLOROPYRIDINE Property

Boiling point:: 114°C/15mmHg(lit.)
Density: 1.233±0.06 g/cm3(Predicted)
refractive index: 1.5440-1.5480
Flash point:: >110℃
storage temp.: Inert atmosphere,Room Temperature
form: clear liquid
pka: -1.65±0.10(Predicted)
color: Colorless to Brown
InChI: InChI=1S/C7H6ClNO/c1-5(10)6-3-2-4-9-7(6)8/h2-4H,1H3
InChIKey: WIWIOUAFBHZLNQ-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=CN=C1Cl)C
CAS DataBase Reference: 55676-21-6

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2795
Product name: 3-Acetyl-2-chloropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: A2795
Product name: 3-Acetyl-2-chloropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $175
Updated: 2025/07/31

TRC

Product number: A168625
Product name: 3-Acetyl-2-chloropyridine
Packaging: 1g
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: W6955
Product name: 3-Acetyl-2-chloropyridine
Packaging: 25g
Price: $239
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA55531
Product name: 3-Acetyl-2-chloropyridine
Packaging: 25g
Price: $280
Updated: 2021/12/16

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3-ACETYL-2-CHLOROPYRIDINE Chemical Properties,Usage,Production

Uses

3-Acetyl-2-chloropyridine is a reagent used in the synthesis of Volitinib, a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor as an anti-cancer agent.

Synthesis

131674-39-0

55676-21-6

Step 2: Synthesis of 1-(2-chloropyridin-3-yl)ethanone 1-(2-Chloropyridin-3-yl)ethanol (10 g, 0.0635 mol) was dissolved in anhydrous acetone (200 mL), transferred to a 1-liter flask and the reaction was carried out under argon protection. The reaction mixture was cooled to -30 °C, followed by slow addition of pure crushed chromic anhydride (19 g, 0.19 mol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, 2-propanol (100 mL) was added to quench the reaction, followed by adjusting the pH with aqueous sodium bicarbonate to 8. The reaction mixture was filtered and the solid was washed with chloroform. The organic and aqueous layers were separated and the aqueous layer was further extracted with chloroform (2 x 100 mL). All organic phases were combined and dried with anhydrous sodium sulfate, followed by concentration under reduced pressure to give the crude 1-(2-chloropyridin-3-yl)ethanone as an oil. The crude product was purified by column chromatography to afford the pure 1-(2-chloropyridin-3-yl)ethanone (8 g, 81% yield). * 1H NMR (CDCl3) δ 8.44 (dd, J = 5 and 2 Hz, 1H), 7.91 (dd, J = 7.5 and 2 Hz, 1H), 7.34 (dd, J = 7.5 and 5 Hz, 1H), 2.68 (s, 3H).

References

[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990, # 9, p. 2409 - 2415
[2] Patent: US2006/47126, 2006, A1. Location in patent: Page/Page column 30
[3] Patent: WO2011/5759, 2011, A2. Location in patent: Page/Page column 77
[4] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 110-111
[5] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0494

3-ACETYL-2-CHLOROPYRIDINE Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Phosphorus oxitrichloride Chloroform Diethyl ether Acetic acid 3-Acetylpyridine

Preparation Products

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3-ACETYL-2-CHLOROPYRIDINE Suppliers

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View Lastest Price from 3-ACETYL-2-CHLOROPYRIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-3-acetyl-pyridine 55676-21-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Nanjing Fred Technology Co., Ltd

Product: 3-Acetyl-2-chloropyridine 55676-21-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%HPLC&GC
Supply Ability: 10ton
Release date: 2023-11-27

Dideu Industries Group Limited

Product: 3-ACETYL-2-CHLOROPYRIDINE 55676-21-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-02

55676-21-6, 3-ACETYL-2-CHLOROPYRIDINERelated Search:

5-Acetyl-2-chloropyridine 4-ACETYL-2-CHLOROPYRIDINE 2-ACETYL-3-CHLOROPYRIDINE 3-Acetylpyridine 2-CHLORO-3-(5-ETHOXYCARBONYL-2-THENOYL)PYRIDINE ETHYL 4-(2-CHLORO-3-PYRIDYL)-4-OXOBUTYRATE 2-CHLORO-3-(3-ETHOXYCARBONYLBENZOYL)PYRIDINE ETHYL 3-(2,6-DICHLORO-5-FLUOROPYRIDIN-3-YL)-3-OXOPROPANOATE 4-(2-CHLORO-3-PYRIDYL)-4-OXOBUTYRONITRILE ETHYL 5-(2-CHLORO-3-PYRIDYL)-5-OXOVALERATE 2-CHLORO-3-(3-METHYL-2-THENOYL)PYRIDINE 2-CHLORO-3-(2-CYANOBENZOYL)PYRIDINE ETHYL 8-(2-CHLORO-3-PYRIDYL)-8-OXOOCTANOATE 2-CHLORO-3-(2-THIAZOLYLCARBONYL)PYRIDINE 2-CHLORO-3-(5-ETHOXYCARBONYL-2-FUROYL)PYRIDINE 2-CHLORO-3-(4-ETHOXYCARBONYLBENZOYL)PYRIDINE ETHYL 7-(2-CHLORO-3-PYRIDYL)-7-OXOHEPTANOATE ETHYL 6-(2-CHLORO-3-PYRIDYL)-6-OXOHEXANOATE

1-(2-chloro-3-pyridinyl)-1-ethanone

2-chloro-3-acetylpyridine

1-(2-chloro-3-pyridinyl)ethanone

1-(2-chloro-3-pyridinyl)ethanone(SALTDATA: FREE)

1-(2-chloropyridin-3-yl)ethan-1-one

1-(2-Chloropyridin-3-yl)ethan-1-one, 2-Chloro-3-ethanoylpyridine

3-Acetyl-2-chloropyridine 95%

Ethanone, 1-(2-chloro-3-pyridinyl)-

3-ACETYL-2-CHLOROPYRIDINE

1-(2-CHLOROPYRIDIN-3-YL)ETHANONE

3-Acetyl-2-chloropyridine &gt

3-ACETYL-2-CHLOROPYRIDINE ISO 9001：2015 REACH

1-(2-Chloropyridin-3-yl)-1-ethanone

55676-21-6

55767-21-6

pharmacetical

Pyridine series

alkyl chloride