Amivantamab

Product Name: Amivantamab
CAS No.: 2171511-58-1
Chemical Name: Amivantamab
Synonyms: Amivantamab;Amivantamab (anti-c-Met);Research Grade Amivantamab;Research Grade Amivantamab (DHB86907)
CBNumber: CB08081157
Formula Weight: 0
MOL File: Mol file

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Amivantamab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Amivantamab Chemical Properties,Usage,Production

Uses

Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells[1].

in vivo

Amivantamab (JNJ-61186372)(i.p, 30 mg/kg, twice a week, 15 days)effectively reduces tumour volume in female thymus-free BALB-c/nu mouse xenograft model of NSCLC with EGFR Exon20ins mutation and has in vivo anti-tumour effects^[2].

References

[1] Keunchil Park, et al. Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study. J Clin Oncol. 2021 Oct 20;39(30):3391-3402. DOI:10.1200/JCO.21.00662
[2] Jiyeon Yun, et al. Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of?EGFR?Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209. DOI:10.1158/2159-8290.CD-20-0116

Amivantamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Amivantamab Suppliers

China 16 United States 1 Global 17

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Amivantamab

Research Grade Amivantamab (DHB86907)

Research Grade Amivantamab

Amivantamab (anti-c-Met)

2171511-58-1