Mirzotamab
- Product Name
- Mirzotamab
- CAS No.
- 2229859-11-2
- Chemical Name
- Mirzotamab
- Synonyms
- Mirzotamab;Mirzotamab (anti-CD276);Research Grade Mirzotamab;Research Grade Mirzotamab (DHJ04003)
- CBNumber
- CB38081178
- Formula Weight
- 0
- MOL File
- Mol file
Mirzotamab Property
- form
- Liquid
- color
- Colorless to light yellow
Mirzotamab Chemical Properties,Usage,Production
Uses
Mirzotamab is an IgG1κ monoclonal antibody targeting to CD276/B7-H3 with anti-tumor activity. Mirzotamab conjugates with Clezutoclax (HY-137774), a BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC)[1][2][3].
References
[1] Tolcher A W, et al. A first-in-human study of mirzotamab clezutoclax as monotherapy and in combination with taxane therapy in relapsed/refractory solid tumors: Dose escalation results. 2021.
[2] Cai Jiaqiang, et al. Antibody-drug conjugate containing BCL-2 family proteolysis agent, preparation method therefor, and use thereof. WO2024153185. 2024.07.25.
[3] Nathanson, David A., et al. Combination therapy for treating glioblastoma. WO2022231996. 2022.11.03.
Mirzotamab Preparation Products And Raw materials
Raw materials
Preparation Products
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