Zelminemab

Product Name: Zelminemab
CAS No.: 2225850-33-7
Chemical Name: Zelminemab
Synonyms: Zelminemab;Zelminemab (anti-PAC1);Research Grade Zelminemab;Research Grade Zelminemab (DHE32801)
CBNumber: CB08081197
Formula Weight: 0
MOL File: Mol file

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Zelminemab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Zelminemab Chemical Properties,Usage,Production

Uses

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor[1].

in vivo

Zelminemab (10 mg/kg; i.v.; once) reduces nociceptive neu-ronal activity in the TCC^[2].

Animal Model:	Sprague-Dawley rats, electricalstimulation was performed on the intact dura mater abovethe middle meningeal artery^[2].
Dosage:	10 mg/kg
Administration:	i.v.; once
Result:	Induced an inhibition of stimulus-evoked nociceptive activity in the trigeminocervical com-plex (TCC).

References

[1] Eloisa Rubio-Beltrán, et al. PACAP38 and PAC1 receptor blockade: a new target for headache? J Headache Pain. 2018 Aug 7;19(1):64. DOI:10.1186/s10194-018-0893-8
[2] Hoffmann J, et al. PAC-1 receptor antibody modulates nociceptive trigeminal activity in rat. Cephalalgia. 2016;36(1S):141–141.

Zelminemab Preparation Products And Raw materials

Raw materials

Preparation Products

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Zelminemab Suppliers

China 14 Global 14

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Zelminemab

Research Grade Zelminemab (DHE32801)

Research Grade Zelminemab

Zelminemab (anti-PAC1)

2225850-33-7