Ethyl 1H-1,2,3-triazole-5-carboxylate
- Product Name
- Ethyl 1H-1,2,3-triazole-5-carboxylate
- CAS No.
- 40594-98-7
- Chemical Name
- Ethyl 1H-1,2,3-triazole-5-carboxylate
- Synonyms
- ethyl 2H-triazole-4-carboxylate;Ethyl 1H-1,2,3-triazole-5-carboxylate;ethyl 1H-1,2,3-triazole-4-carboxylate;1H-1,2,3-Triazole-5-carboxylic acid, ethyl ester;1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID, ETHYL ESTER;3H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;1H-1,2,3-Triazole-4-carboxylicacid,ethylester(9CI)
- CBNumber
- CB0841995
- Molecular Formula
- C5H7N3O2
- Formula Weight
- 141.13
- MOL File
- 40594-98-7.mol
Ethyl 1H-1,2,3-triazole-5-carboxylate Property
- Melting point:
- 102-104 °C
- Boiling point:
- 284.7±13.0 °C(Predicted)
- Density
- 1.299±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.94±0.70(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T767415
- Product name
- 1H-1,2,3-Triazole-5-carboxylicAcidEthylEster
- Packaging
- 250mg
- Price
- $415
- Updated
- 2021/12/16
- Product number
- 089677
- Product name
- Ethyl 1H-1,2,3-triazole-4-carboxylate
- Packaging
- 1g
- Price
- $466
- Updated
- 2021/12/16
- Product number
- CS-0037024
- Product name
- Ethyl1H-1,2,3-triazole-5-carboxylate
- Purity
- 99.07%
- Packaging
- 5g
- Price
- $321
- Updated
- 2021/12/16
- Product number
- 67343
- Product name
- 1H-1,2,3-Triazole-5-carboxylicAcidEthylEster
- Packaging
- 250mg
- Price
- $875
- Updated
- 2021/12/16
- Product number
- CHM0078687
- Product name
- 1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID, ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
Ethyl 1H-1,2,3-triazole-5-carboxylate Chemical Properties,Usage,Production
Uses
1H-1,2,3-Triazole-5-carboxylic Acid Ethyl Ester is used in the synthesis potent inhibitors of bacterial β-lactamase.
Synthesis
4648-54-8
623-47-2
40594-98-7
Ethyl propargylate and trimethylmethylsilyl azide were injected through a 2 mL loop in a Vapourtec R2+/R4 flow system equipped with three PTFE reactor coils (10 mL) and a 250 psi back pressure regulator. The flow rate was set at 0.5 mL/min and the residence time was 1.5 hours. The system was heated to 140°C. Injections were performed every 40 min and the solvent used was acetonitrile. The total mixture flowing from the reactor was collected and a total of 5 injections were performed. The collected mixtures were combined and the acetonitrile was removed under vacuum by rotary evaporator (the collection flask of the rotary evaporator was pre-filled with saturated aqueous NaHCO3 solution to quench any HN3 that might be generated). The residual solid was dissolved in ethyl acetate and the organic phase was washed with saturated brine (3 times), dried over anhydrous sodium sulfate, filtered and the solvent evaporated. The crude product was stirred with a minimal amount of ether, filtered and dried to give ethyl 1H-1,2,3-triazole-5-carboxylate (8.65 g, 81% yield) as a white solid. Mass spectrum (ESI): m/z=142.1 [M+H]+.
References
[1] Journal of Heterocyclic Chemistry, 2009, vol. 46, # 1, p. 131 - 133
[2] Patent: WO2017/89389, 2017, A1. Location in patent: Page/Page column 35
Ethyl 1H-1,2,3-triazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 1H-1,2,3-triazole-5-carboxylate manufacturers
- Product
- Ethyl 1H-1,2,3-triazole-5-carboxylate 40594-98-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23