4-BROMO-6-FLUOROINDAN-1-ONE
- Product Name
- 4-BROMO-6-FLUOROINDAN-1-ONE
- CAS No.
- 174603-56-6
- Chemical Name
- 4-BROMO-6-FLUOROINDAN-1-ONE
- Synonyms
- 4-BROMO-6-FLUOROINDAN-1-ONE;4-Bromo-6-fluoro-1-indanone;4-bromo-6-fluoro-2,3-dihydroinden-1-one;4-broMo-6-fluoro-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one,4-broMo-6-fluoro-2,3-dihydro-
- CBNumber
- CB0842154
- Molecular Formula
- C9H6BrFO
- Formula Weight
- 229.05
- MOL File
- 174603-56-6.mol
4-BROMO-6-FLUOROINDAN-1-ONE Property
- Boiling point:
- 301.1±42.0 °C(Predicted)
- Density
- 1.691±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C9H6BrFO/c10-8-4-5(11)3-7-6(8)1-2-9(7)12/h3-4H,1-2H2
- InChIKey
- KBBCLUTZUIWTON-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C(Br)=CC(F)=C2)CC1
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B293365
- Product name
- 4-Bromo-6-fluoroindan-1-one
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- HCH0036676
- Product name
- 4-BROMO-6-FLUOROINDAN-1-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1437.98
- Updated
- 2021/12/16
- Product number
- W3816
- Product name
- 4-Bromo-6-fluoroindan-1-one
- Packaging
- 10g
- Price
- $2255
- Updated
- 2021/12/16
- Product number
- HCH0036676
- Product name
- 4-BROMO-6-FLUOROINDAN-1-ONE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $3228.23
- Updated
- 2021/12/16
- Product number
- A113575
- Product name
- 4-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $9
- Updated
- 2021/12/16
4-BROMO-6-FLUOROINDAN-1-ONE Chemical Properties,Usage,Production
Synthesis
174603-55-5
174603-56-6
Under argon protection, 3-(2-bromo-4-fluorophenyl)propionic acid (1.2 g) was added to trifluoromethanesulfonic acid (15 mL) in batches and the reaction was carried out at room temperature. Subsequently, the reaction mixture was stirred at 60°C for 2 hours, then warmed to 80°C and continued stirring for 16 hours. After completion of the reaction, it was cooled to room temperature and the mixture was slowly poured into ice water. The aqueous phase was extracted twice with ethyl acetate. The organic phase was combined and washed sequentially with saturated aqueous Na2CO3 and brine. The organic phase was dried over anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. The resulting residue was stirred with dichloromethane (40 mL), filtered and washed with dichloromethane. The dichloromethane phase was combined and concentrated to give the target compound 4-bromo-6-fluoro-2,3-dihydro-1H-inden-1-one. Yield: 970 mg; liquid chromatography (Method 3): tR = 0.60 min; mass spectrometry (ESI+): m/z = 229 [M + H]+.
References
[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 409 - 416
[2] Patent: WO2013/144098, 2013, A1. Location in patent: Page/Page column 114; 115
[3] Patent: WO2015/36759, 2015, A1
4-BROMO-6-FLUOROINDAN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-6-FLUOROINDAN-1-ONE Suppliers
- Tel
- 0512-63101022 13912623614
- Fax
- 86-512-6310 1035
- sales@chontech.com
- Country
- Austria
- ProdList
- 220
- Advantage
- 58
View Lastest Price from 4-BROMO-6-FLUOROINDAN-1-ONE manufacturers
- Product
- 4-Bromo-6-fluoro-1-indanone 174603-56-6
- Price
- US $0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 5kgs/month
- Release date
- 2021-07-11
- Product
- 4-BROMO-6-FLUOROINDAN-1-ONE 174603-56-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13