ChemicalBook > CAS DataBase List > Pygenic acid A

Pygenic acid A

Product Name: Pygenic acid A
CAS No.: 52213-27-1
Chemical Name: Pygenic acid A
Synonyms: Pygenic acid A;PUNICALAGINS A&B(P);3-Epicorosolic acid;2,3-Dihydroxy-12-ursen-28-oic acid;(2α,3α)-2,3-Dihydroxyurs- 12-en-28-oic acid;(2alpha,3alpha)-2,3-Dihydroxy-urs-12-en-28-oic acid;2α,3α-Dihydroxy-19β-methyl-30-noroleana-12-ene-28-oic acid
CBNumber: CB0947158
Molecular Formula: C30H48O4
Formula Weight: 472.7
MOL File: 52213-27-1.mol

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Pygenic acid A Property

solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PXT0002837
Product name: PYGENIC ACID A
Purity: 95.00%
Packaging: 5MG
Price: $505.36
Updated: 2021/12/16

Crysdot

Product number: CD32001117
Product name: 3-Epicorosolicacid
Purity: 95+%
Packaging: 5mg
Price: $730
Updated: 2021/12/16

Arctom

Product number: CFN98851
Product name: 3-Epicorosolicacid
Purity: ≥98%
Packaging: 5mg
Price: $463
Updated: 2021/12/16

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Pygenic acid A Chemical Properties,Usage,Production

Description

3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction. 3-Epicorosolic acid shows both potent α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 30.18 and 4.08 μg/ml respectively. 3. 3-Epicorosolic acid shows mixed type inhibition against PTP1B, while it shows uncompetitive inhibition against α-glucosidase; suggests that it has potential antidiabetic activity. 4. 3-Epicorosolic acid possesses the ability to inhibit the expression of one or more inflammatory genes induced by 12-O-tetradecanoylphorbol-13 acetate in mouse skin, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.

Uses

Pygenic acid A is a natural compound that can be found in Prunella vulgaris. Pygenic acid A induces apoptosis in metastatic breast cancer cells. Pygenic acid A can be used for the research of diabetes, inflammatory diseases, and cancers[1].

target

Immunology & Inflammation related

References

[1] Ga-Eun Lim, et al. Pygenic Acid A (PA) Sensitizes Metastatic Breast Cancer Cells to Anoikis and Inhibits Metastasis In Vivo. Int J Mol Sci. 2020 Nov; 21(22): 8444. DOI:10.3390/ijms21228444

Pygenic acid A Preparation Products And Raw materials

Raw materials

Preparation Products

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52213-27-1, Pygenic acid ARelated Search:

hydroxygenkwanin beta-Eudesmol alpha-Terpineol beta-Sitosterol Hydroxyecdysone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one alpha-Cyperone Artemether MOSLOFLAVONE euscaphic acid Pygenic acid A 1B,2A,3A,24-TETRAHYDROXY-12-URSEN-28-OIC ACID 2,3-DIHYDROXY-(2ALPHA,3ALPHA)-URS-12-EN-28-OIC ACID METHYL ESTER 2,3-BIS(ACETYLOXY)-(2ALPHA,3ALPHA)-URS-12-EN-28-OIC ACID 2A,3A,24-TRIHYDROXY-12-URSEN-28-OIC ACID 2,3-BIS(ACETYLOXY)-(2ALPHA,3ALPHA)-URS-12-EN-28-OIC ACID METHYL ESTER

(2alpha,3alpha)-2,3-Dihydroxy-urs-12-en-28-oic acid

Pygenic acid A

2α,3α-Dihydroxy-19β-methyl-30-noroleana-12-ene-28-oic acid

PUNICALAGINS A&B(P)

2,3-Dihydroxy-12-ursen-28-oic acid

3-Epicorosolic acid

(2α,3α)-2,3-Dihydroxyurs- 12-en-28-oic acid

52213-27-1

Pentacyclic Triterpenes