ChemicalBook > CAS DataBase List > 2-Chloro-5-hydroxypyrimidine

2-Chloro-5-hydroxypyrimidine

Product Name
2-Chloro-5-hydroxypyrimidine
CAS No.
4983-28-2
Chemical Name
2-Chloro-5-hydroxypyrimidine
Synonyms
2-Chloropyrimidin-5-ol;Piribedil Impurity 17;2-Chloro-5-pyrimidinol;5-PyriMidinol,2-chloro-;2-Chloro-5-hydroxypyrimid...;2-Chloro-5-hydroxypyrimidine;2-Chloro-5-hydroxypyrimidine 98%;5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI);2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH;TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2
CBNumber
CB0947875
Molecular Formula
C4H3ClN2O
Formula Weight
130.53
MOL File
4983-28-2.mol
More
Less

2-Chloro-5-hydroxypyrimidine Property

Melting point:
195-196 °C
Boiling point:
328.1±15.0 °C(Predicted)
Density 
1.513±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
6.17±0.23(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C4H3ClN2O/c5-4-6-1-3(8)2-7-4/h1-2,8H
InChIKey
BOGPIHXNWPTGNH-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(O)C=N1
CAS DataBase Reference
4983-28-2(CAS DataBase Reference)
More
Less

Safety

HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
C3685
Product name
2-Chloro-5-hydroxypyrimidine
Purity
min. 98.0 %
Packaging
1G
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
C3685
Product name
2-Chloro-5-hydroxypyrimidine
Purity
min. 98.0 %
Packaging
5G
Price
$126
Updated
2025/07/31
TRC
Product number
C373980
Product name
2-Chloro-5-hydroxypyrimidine
Packaging
1g
Price
$70
Updated
2021/12/16
TRC
Product number
C373980
Product name
2-Chloro-5-hydroxypyrimidine
Packaging
10g
Price
$275
Updated
2021/12/16
TRC
Product number
C373980
Product name
2-Chloro-5-hydroxypyrimidine
Packaging
25g
Price
$495
Updated
2021/12/16
More
Less

2-Chloro-5-hydroxypyrimidine Chemical Properties,Usage,Production

Uses

2-Chloro-5-hydroxypyrimidine is an intermediate used to synthesize tandospirone derivatives with anxiolytic activities.

Synthesis

2-Chloro-5-methoxypyrimidine (0.46 g, 3.18 mmol) in methylene chloride (10 mL) was treated with 1.0 N boron tribromide (16 mL, 16 mmol) at room temperature. The solution was stirred overnight. After that, the reaction was partitioned between saturated NaHCO3 and DCM. The aqueous layer was extracted with additional DCM. Combined the organic layers and dried (MgSO4), filtered, and concentrated to obtain the crude product. The residue was purified by flash column chromatography on silica gel to give 2-Chloro-5-hydroxypyrimidine.

References

[1] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 225
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27
[3] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24-25
[4] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 50
[5] Patent: US5589478, 1996, A

2-Chloro-5-hydroxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Chloro-5-hydroxypyrimidine Suppliers

Austria 1 China 262 Europe 2 Germany 1 India 2 Japan 1 United Kingdom 3 United States 16 Global 288
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188
Email
marketing@pharmablock.com
Country
China
ProdList
9126
Advantage
58
Haimen Ruiyi Medical Tech Co., LTD
Tel
021-54718086
Fax
021-54711707
Email
sales5@ruiyitech.com
Country
China
ProdList
271
Advantage
58
Hangzhou Copiore Chemical Co., Ltd.
Tel
0571-56501939;0571-56076030 13757145729
Fax
0571-56501939
Email
sales@copiore.com
Country
China
ProdList
299
Advantage
58
Henan Dongyao Pharmaceutical Technology Co., Ltd
Tel
18519331287; 18519331287
Email
1751713684@qq.com
Country
China
ProdList
220
Advantage
58
Nanjing Intermate Technology Co., Ltd
Tel
18501091076 18501091076
Email
57715449@qq.com
Country
China
ProdList
63
Advantage
58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
918
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Changzhou Huanling Chemical Co., Ltd.
Tel
0519-89803565 13776850645
Fax
0519-89803575
Email
info4@huanlingchem.com
Country
China
ProdList
891
Advantage
68
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
28-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
510
Advantage
57
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
PSN Pharmaceutical Technology Co., Ltd.
Tel
86-25-57062118
Fax
86-25-57065896
Email
sales@jspsn.com
Country
China
ProdList
496
Advantage
57
NanTong Chemistar Chemical Co.,Ltd
Tel
025-52643182 13914798241
Fax
025-52643184
Email
doria@chemipioneer.com.cn
Country
China
ProdList
56
Advantage
62
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
993
Advantage
62
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Acorn PharmaTech Co., Ltd.
Tel
025-58395930
Fax
025-5861-9182
Email
sales@acornpharma.com
Country
China
ProdList
982
Advantage
60
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
+86-021-54824098 15317552526
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
254
Advantage
55
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Changzhou Chemscaler Pharmtech Co., Ltd.
Tel
0519-81096292 15312577869
Email
chemscaler@yahoo.com.cn
Country
China
ProdList
311
Advantage
60
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Suzhou Ryan Pharmachem Technology Co.,Ltd
Tel
0512-66585217 13962137180
Fax
0512-82177549
Email
sales@ryanchem.com
Country
China
ProdList
384
Advantage
55
Hebei Summedchem Co.,Ltd
Tel
0319-5801333-8008 15630992918
Email
sales@summedchem.com
Country
China
ProdList
965
Advantage
58
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1839
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3853
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Chemfun Medical Technology(Shanghai) Co., Ltd.
Tel
021-67220633 021-54824098
Fax
+86-21-54824069
Email
chemfun@chemfun.net
Country
China
ProdList
491
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shandong Juntai Pharmaceutical Co., LTD.
Tel
15853135817
Fax
0531-66958526
Email
sales@h2opharm.com
Country
China
ProdList
201
Advantage
55
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Nanjing Duolong Bio-tech Co.,Ltd.
Tel
18905173768
Fax
025-83263139
Email
52513593@qq.com
Country
China
ProdList
2331
Advantage
50
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Shanghai Rong Lin Medical Technology Co., Ltd.
Tel
18602194589
Email
lincy-110@163.com
Country
China
ProdList
863
Advantage
58
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
More
Less

View Lastest Price from 2-Chloro-5-hydroxypyrimidine manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
2-Chloro-5-hydroxypyrimidine? 4983-28-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-27
Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-5-hydroxypyrimidine 4983-28-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-04
Dideu Industries Group Limited
Product
2-Chloro-5-hydroxypyrimidine 4983-28-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-09

4983-28-2, 2-Chloro-5-hydroxypyrimidineRelated Search:

HYDROXYAPATITE TYPE I Glycolic acid 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Sulfadiazine 2-Chloropyrimidine Uracil Hydroxy silicone oil Chrysin Silver sulfadiazine 4-Hydroxybenzaldehyde 5-Hydroxypyrimidine 2-Chloro-5-fluoropyrimidine Tandospirone 1-N-Boc-4-pyriMidin-2-yl-piperazine (3aR,4R,7S,7aS)-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]hexahydro-1H-4,7-methanoisoindole-1,3-dione Difluorochloromethane Camptothecin Series--10-hydroxycamptothecin 2,4-Dichloro-5-methoxypyrimidine

  • 2-Chloro-5-hydroxypyrimidine 98%
  • 2-Chloro-5-hydroxypyrimidine
  • 5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI)
  • 2-Chloropyrimidin-5-ol
  • 2-Chloro-5-hydroxypyrimid...
  • 5-PyriMidinol,2-chloro-
  • 2-Chloropyrimidin-5-ol, 2-Chloro-5-hydroxy-1,3-diazine
  • 2-Chloro-5-pyrimidinol
  • 2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH
  • Piribedil Impurity 17
  • TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2
  • 4983-28-2
  • 1983-28-2
  • Heterocycle-Pyrimidine series
  • PYRIMIDINE
  • pharmacetical
  • Pyrimidines