2-Chloro-5-hydroxypyrimidine

Product Name: 2-Chloro-5-hydroxypyrimidine
CAS No.: 4983-28-2
Chemical Name: 2-Chloro-5-hydroxypyrimidine
Synonyms: 2-Chloropyrimidin-5-ol;Piribedil Impurity 17;2-Chloro-5-pyrimidinol;5-PyriMidinol,2-chloro-;2-Chloro-5-hydroxypyrimid...;2-Chloro-5-hydroxypyrimidine;2-Chloro-5-hydroxypyrimidine 98%;5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI);2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH;TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2
CBNumber: CB0947875
Molecular Formula: C4H3ClN2O
Formula Weight: 130.53
MOL File: 4983-28-2.mol

More

Less

2-Chloro-5-hydroxypyrimidine Property

Melting point:: 195-196 °C
Boiling point:: 328.1±15.0 °C(Predicted)
Density: 1.513±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 6.17±0.23(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C4H3ClN2O/c5-4-6-1-3(8)2-7-4/h1-2,8H
InChIKey: BOGPIHXNWPTGNH-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(O)C=N1
CAS DataBase Reference: 4983-28-2(CAS DataBase Reference)

More

Less

Safety

HS Code: 29335990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: C3685
Product name: 2-Chloro-5-hydroxypyrimidine
Purity: min. 98.0 %
Packaging: 1G
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: C3685
Product name: 2-Chloro-5-hydroxypyrimidine
Purity: min. 98.0 %
Packaging: 5G
Price: $126
Updated: 2025/07/31

TRC

Product number: C373980
Product name: 2-Chloro-5-hydroxypyrimidine
Packaging: 1g
Price: $70
Updated: 2021/12/16

TRC

Product number: C373980
Product name: 2-Chloro-5-hydroxypyrimidine
Packaging: 10g
Price: $275
Updated: 2021/12/16

TRC

Product number: C373980
Product name: 2-Chloro-5-hydroxypyrimidine
Packaging: 25g
Price: $495
Updated: 2021/12/16

More

Less

2-Chloro-5-hydroxypyrimidine Chemical Properties,Usage,Production

Uses

2-Chloro-5-hydroxypyrimidine is an intermediate used to synthesize tandospirone derivatives with anxiolytic activities.

Synthesis

2-Chloro-5-methoxypyrimidine (0.46 g, 3.18 mmol) in methylene chloride (10 mL) was treated with 1.0 N boron tribromide (16 mL, 16 mmol) at room temperature. The solution was stirred overnight. After that, the reaction was partitioned between saturated NaHCO3 and DCM. The aqueous layer was extracted with additional DCM. Combined the organic layers and dried (MgSO4), filtered, and concentrated to obtain the crude product. The residue was purified by flash column chromatography on silica gel to give 2-Chloro-5-hydroxypyrimidine.

References

[1] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 225
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27
[3] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24-25
[4] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 50
[5] Patent: US5589478, 1996, A

2-Chloro-5-hydroxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Chloro-5-hydroxypyrimidine Suppliers

Austria 1 China 262 Europe 2 Germany 1 India 2 Japan 1 United Kingdom 3 United States 16 Global 288

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Email: marketing@pharmablock.com
Country: China
ProdList: 9126
Advantage: 58

Haimen Ruiyi Medical Tech Co., LTD

Tel: 021-54718086
Fax: 021-54711707
Email: sales5@ruiyitech.com
Country: China
ProdList: 271
Advantage: 58

Hangzhou Copiore Chemical Co., Ltd.

Tel: 0571-56501939;0571-56076030 13757145729
Fax: 0571-56501939
Email: sales@copiore.com
Country: China
ProdList: 299
Advantage: 58

Henan Dongyao Pharmaceutical Technology Co., Ltd

Tel: 18519331287; 18519331287
Email: 1751713684@qq.com
Country: China
ProdList: 220
Advantage: 58

Nanjing Intermate Technology Co., Ltd

Tel: 18501091076 18501091076
Email: 57715449@qq.com
Country: China
ProdList: 63
Advantage: 58

SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
Fax: 0838-5675535
Email: nbcxkj@126.com
Country: China
ProdList: 918
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from 2-Chloro-5-hydroxypyrimidine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 2-Chloro-5-hydroxypyrimidine? 4983-28-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Chloro-5-hydroxypyrimidine 4983-28-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-04

Dideu Industries Group Limited

Product: 2-Chloro-5-hydroxypyrimidine 4983-28-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-09

4983-28-2, 2-Chloro-5-hydroxypyrimidineRelated Search:

HYDROXYAPATITE TYPE I Glycolic acid 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Sulfadiazine 2-Chloropyrimidine Uracil Hydroxy silicone oil Chrysin Silver sulfadiazine 4-Hydroxybenzaldehyde 5-Hydroxypyrimidine 2-Chloro-5-fluoropyrimidine Tandospirone 1-N-Boc-4-pyriMidin-2-yl-piperazine (3aR,4R,7S,7aS)-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]hexahydro-1H-4,7-methanoisoindole-1,3-dione Difluorochloromethane Camptothecin Series--10-hydroxycamptothecin 2,4-Dichloro-5-methoxypyrimidine

2-Chloro-5-hydroxypyrimidine 98%

2-Chloro-5-hydroxypyrimidine

5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI)

2-Chloropyrimidin-5-ol

2-Chloro-5-hydroxypyrimid...

5-PyriMidinol,2-chloro-

2-Chloropyrimidin-5-ol, 2-Chloro-5-hydroxy-1,3-diazine

2-Chloro-5-pyrimidinol

2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH

Piribedil Impurity 17

TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2

4983-28-2

1983-28-2

Heterocycle-Pyrimidine series

PYRIMIDINE

pharmacetical

Pyrimidines