6-(Trifluoromethyl)-1-indanone
- Product Name
- 6-(Trifluoromethyl)-1-indanone
- CAS No.
- 68755-37-3
- Chemical Name
- 6-(Trifluoromethyl)-1-indanone
- Synonyms
- 6-(trifluoromethyl)indan-1-one;6-(Trifluoromethyl)-1-indanone;6-(Trifluoromethyl)-1-indanone 97%;6-(Trifluoromethyl)-2,3-dihydro-1-indenone;6-(trifluoromethyl)-2,3-dihydroinden-1-one;2,3-Dihydro-6-(trifluoromethyl)-1H-inden-1-one;6-(trifluoroMethyl)-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-6-(trifluoroMethyl)-
- CBNumber
- CB0966203
- Molecular Formula
- C10H7F3O
- Formula Weight
- 200.16
- MOL File
- 68755-37-3.mol
6-(Trifluoromethyl)-1-indanone Property
- Boiling point:
- 76-78 °C/0.2 mmHg
- Density
- 1.321 g/mL at 25 °C
- refractive index
- n20/D 1.496
- Flash point:
- 110 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to brown Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 681652
- Product name
- 6-(Trifluoromethyl)-1-indanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $115
- Updated
- 2022/05/15
- Product number
- T899628
- Product name
- 6-(Trifluoromethyl)-1-indanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC906472
- Product name
- 6-(Trifluoromethyl)-1-indanone
- Purity
- 98%
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- PC906472
- Product name
- 6-(Trifluoromethyl)-1-indanone
- Purity
- 98%
- Packaging
- 1g
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 0618AC
- Product name
- 6-(Trifluoromethyl)-1-indanone
- Packaging
- 5g
- Price
- $397
- Updated
- 2021/12/16
6-(Trifluoromethyl)-1-indanone Chemical Properties,Usage,Production
Uses
6-(Trifluoromethyl)-1-indanone is a useful research chemical compound used as a reactant in the enantioselective synthesis of homoallylic azides and nitriles.
Synthesis
68755-36-2
68755-37-3
Step D: Synthesis of 6-(trifluoromethyl)-1-indanone To a mixed solution of 3-(2-bromo-4-(trifluoromethyl)phenyl)propanoic acid (6.40 g, 21.5 mmol) in THF (300 mL) and hexane (80 mL) was slowly added a 2.5 M n-butyllithium hexane solution (19 mL) at -78°C. The reaction mixture was stirred at this temperature for 15 minutes and then carefully poured into 2N HCl solution (150 mL) to terminate the reaction. The organic and aqueous layers were separated and the aqueous layer was extracted with ether. All organic layers were combined, washed sequentially with NaHCO3 solution, water and brine, dried over anhydrous MgSO4 and concentrated. Purification by silica gel column chromatography (eluent: 10-20% ethyl acetate in hexane solution) afforded 6-(trifluoromethyl)-1-indanone (2.2 g, yield 51%) as an oil.MS (ESI) calculated value of C10H7F3O(M+H)+: 201.0; measured value: 201.0.
References
[1] Patent: US2005/261310, 2005, A1. Location in patent: Page/Page column 22
[2] Patent: US4132737, 1979, A
6-(Trifluoromethyl)-1-indanone Preparation Products And Raw materials
Raw materials
Preparation Products
6-(Trifluoromethyl)-1-indanone Suppliers
- Tel
- --
- Fax
- --
- Country
- United Kingdom
- ProdList
- 6309
- Advantage
- 46
View Lastest Price from 6-(Trifluoromethyl)-1-indanone manufacturers
- Product
- 6-(Trifluoromethyl)-1-indanone 68755-37-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09