4-Morpholinoaniline
- Product Name
- 4-Morpholinoaniline
- CAS No.
- 2524-67-6
- Chemical Name
- 4-Morpholinoaniline
- Synonyms
- N-(4-AMINOPHENYL)MORPHOLINE;AKOS B025582;AKOS BB-8569;ASISCHEM Z37706;AKOS BBS-00006991;4-MORPHOLINOANILINE;ART-CHEM-BB B025582;P-MORPHOLINOANILINE;4-MORPHOLIONOANILINE;4-Morpholine Aniline
- CBNumber
- CB1102565
- Molecular Formula
- C10H14N2O
- Formula Weight
- 178.23
- MOL File
- 2524-67-6.mol
4-Morpholinoaniline Property
- Melting point:
- 132-135 °C(lit.)
- Boiling point:
- 310.47°C (rough estimate)
- Density
- 1.0777 (rough estimate)
- refractive index
- 1.5250 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in chloroform, ethyl acetate.
- pka
- 6.72±0.40(Predicted)
- form
- Crystalline Powder
- color
- Purple to brown
- BRN
- 150957
- InChI
- InChI=1S/C10H14N2O/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8,11H2
- InChIKey
- PHNDZBFLOPIMSM-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(N2CCOCC2)C=C1
- CAS DataBase Reference
- 2524-67-6(CAS DataBase Reference)
- EPA Substance Registry System
- 4-(4-Morpholino)aniline (2524-67-6)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-22
- RIDADR
- UN2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 6.1
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 197157
- Product name
- 4-Morpholinoaniline
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $57
- Updated
- 2023/01/07
- Product number
- M1466
- Product name
- 4-Morpholinoaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- M1466
- Product name
- 4-Morpholinoaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- M723745
- Product name
- 4-Morpholinoaniline
- Packaging
- 100g
- Price
- $595
- Updated
- 2021/12/16
- Product number
- 60535
- Product name
- 4-Morpholinoaniline
- Packaging
- 10g
- Price
- $650
- Updated
- 2021/12/16
4-Morpholinoaniline Chemical Properties,Usage,Production
Chemical Properties
PURPLE TO BROWN CRYSTALLINE POWDER
Uses
4-(4-Morpholinyl)aniline is used in the preparation of central nervous system (CNS) active agents, also used in the color developing process in photographs.
Uses
4-Morpholinoaniline is a morpholine derivative used in the preparation of central nervous system (CNS) active agents. 4-Morpholinoaniline is also one of the primary aromatic amines used in the colour developing process in photographs.
Synthesis
10389-51-2
2524-67-6
The general procedure for the synthesis of 4-(4-morpholinyl)aniline from 4-(4-nitrophenyl)morpholine was as follows: referring to the method of Example 20, 4-(4-nitrophenyl)morpholine (10.3 g, 49.5 mmol; purchased from Lancaster Synthesis) was suspended in methanol (130 mL) and a methanolic solution of 2 M ammonia (70 mL). 1 mL of water and 5% palladium carbon catalyst (100 mg) were added. The mixture was placed in a Paar hydrogenation unit and hydrogenated at 50 psi hydrogen pressure for 1 hour. Upon completion of the reaction, the reaction mixture was allowed to cool to room temperature, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by solvent recrystallization from a mixture of ethyl acetate/hexane to give 4-(4-morpholinyl)aniline as a light purple solid (6.2 g, 70% yield, melting point 132-133 °C). The product was analyzed by GC/MS (EI, M+) and showed a molecular ion peak m/z=178.
References
[1] Applied Organometallic Chemistry, 2018, vol. 32, # 1,
[2] Chemistry - An Asian Journal, 2017, vol. 12, # 7, p. 785 - 791
[3] Patent: EP2949647, 2015, A1. Location in patent: Paragraph 0120
[4] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 896 - 905
[5] Patent: US2013/45977, 2013, A1. Location in patent: Paragraph 0215; 0216; 0217; 0218
4-Morpholinoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Morpholinoaniline Suppliers
- Tel
- --
- Fax
- --
- sales21@chemicalland21.com
- Country
- South Korea
- ProdList
- 6303
- Advantage
- 74
View Lastest Price from 4-Morpholinoaniline manufacturers
- Product
- 4-Morpholinoaniline 2524-67-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-28
- Product
- 4-Morpholinoaniline 2524-67-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-Morpholinoaniline 2524-67-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99.99%
- Supply Ability
- 1kg-10MT
- Release date
- 2019-05-24