Description References
ChemicalBook > CAS DataBase List > Pyridazine, 3-bromo- (9CI)

Pyridazine, 3-bromo- (9CI)

Description References
Product Name
Pyridazine, 3-bromo- (9CI)
CAS No.
88491-61-6
Chemical Name
Pyridazine, 3-bromo- (9CI)
Synonyms
3-bromopyridazine;3-bromo- (9CI);Pyridazine, 3-broMo-;3-Bromopyridazine ,97%;Pyridazine, 3-bromo- (9CI);3-broMopyridazine hydrobroMide;Pyridazine, 3-bromo- (9CI) ISO 9001:2015 REACH
CBNumber
CB11044310
Molecular Formula
C4H3BrN2
Formula Weight
158.98
MOL File
88491-61-6.mol
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Pyridazine, 3-bromo- (9CI) Property

Melting point:
73-74 °C
Boiling point:
270.0±13.0 °C(Predicted)
Density 
1.726±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
solid
pka
0.99±0.10(Predicted)
color 
Yellow to reddish brown
CAS DataBase Reference
88491-61-6
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
B695863
Product name
3-Bromopyridazine
Packaging
100mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-W004020
Product name
3-Bromopyridazine
Purity
99.83%
Packaging
1g
Price
$55
Updated
2021/12/16
Oakwood
Product number
078228
Product name
3-Bromopyridazine
Packaging
250mg
Price
$26
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB72022
Product name
3-Bromopyridazine
Packaging
250mg
Price
$65
Updated
2021/12/16
Oakwood
Product number
078228
Product name
3-Bromopyridazine
Packaging
1g
Price
$76
Updated
2021/12/16
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Pyridazine, 3-bromo- (9CI) Chemical Properties,Usage,Production

Description

3-Bromopyridine can undergo lithiation with LDA at low temperatures in the 4-position: Heterocycles, involved in formation of the Grignard by Mg exchange with i-PrMgCl and in transmetallation of the lithiated derivative with zinc chloride followed by treatment with an electrophile as a route to 4-substituted 3-bromopyridines1-4. 3-Bromopyridine is also used as an intermediate in the synthesis of Active Pharmaceutical Ingredients especially Abiraterone acetate (an antiandrogen medication which is used in the treatment of prostate cancer) and Zimelidine (selective serotonin reuptake inhibitor (SSRI) antidepressants)5.

References

  1. Jennifer A. Love Dr.; John P. Morgan.;Tina M. Trnka.;Robert H. Grubbs Prof. A Practical and Highly Active Ruthenium-Based Catalyst that Effects the Cross Metathesis of Acrylonitrile. Angewandte Chemie International Edition. 2002, 41 (21), 4035-4037.
  2. Wenjie Li.; Dorian P. Nelson.; Mark S. Jensen.; R. Scott Hoerrner.; Dongwei Cai.; Robert D. Larsen.; Paul J. Reider. An Improved Protocol for the Preparation of 3-Pyridyland Some Arylboronic Acids. J. Org. Chem. 2002, 57 (16), 5394-5397.
  3. https://www.alfa.com/en/catalog/A12894/
  4. Cai, Dongwei, R. D. Larsen, and P. J. Reider. "Effective lithiation of 3-bromopyridine: synthesis of 3-pyridine boronic acid and variously 3-substituted pyridines." Cheminform 33.38(2002):4285-4287.
  5. www.jubl.com/uploads/files/48msds_msds-3-bromopyridine.pdf

Pyridazine, 3-bromo- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pyridazine, 3-bromo- (9CI) manufacturers

Henan Fengda Chemical Co., Ltd
Product
3-Bromopyridazine 88491-61-6
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-02
Shanghai Rlavie Technology Co ltd
Product
3-bromopyridazine 88491-61-6
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
100kgs/month
Release date
2021-11-27
Dideu Industries Group Limited
Product
Pyridazine, 3-bromo- (9CI) 88491-61-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-02