Diethyl squarate

Product Name: Diethyl squarate
CAS No.: 5231-87-8
Chemical Name: Diethyl squarate
Synonyms: DIETHYL SQUARATE;3,4-DiethoxycycL;DIETHYL SUQUARATE;DiethylSquarate98%;Diethyl quadratate;TIMTEC-BB SBB008498;obut-3-ene-1,2-dione;DIETHOXYCYCLOBUTENEDIONE;SQUARIC ACID DIETHYL ESTER;SUQUARIC ACID DIETHYL ESTER
CBNumber: CB1106356
Molecular Formula: C8H10O4
Formula Weight: 170.16
MOL File: 5231-87-8.mol

More

Less

Diethyl squarate Property

Melting point:: 13-18 °C
Boiling point:: 95 °C0.1 mm Hg(lit.)
Density: 1.15 g/mL at 25 °C(lit.)
refractive index: n20/D 1.509(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
form: Liquid
color: Clear yellow to light brownish
Water Solubility: insoluble
BRN: 640626
InChIKey: DFSFLZCLKYZYRD-UHFFFAOYSA-N
CAS DataBase Reference: 5231-87-8(CAS DataBase Reference)
NIST Chemistry Reference: 3,4-Diethoxy-3-cyclobutene-1,2-dione(5231-87-8)

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-42/43
Safety Statements: 7-26-37/39-24-23
WGK Germany: 3
RTECS: GU1772466
F: 10
Hazard Note: Irritant
HS Code: 29145090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 310778
Product name: 3,4-Diethoxy-3-cyclobutene-1,2-dione
Purity: 98%
Packaging: 5g
Price: $136
Updated: 2025/07/31

TCI Chemical

Product number: D3253
Product name: 3,4-Diethoxy-3-cyclobutene-1,2-dione
Purity: >98.0%(GC)
Packaging: 5g
Price: $78
Updated: 2025/07/31

TCI Chemical

Product number: D3253
Product name: 3,4-Diethoxy-3-cyclobutene-1,2-dione
Purity: >98.0%(GC)
Packaging: 25g
Price: $314
Updated: 2025/07/31

TRC

Product number: D441978
Product name: 3,4-Diethoxycyclobut-3-ene-1,2-dione
Packaging: 100mg
Price: $40
Updated: 2021/12/16

TRC

Product number: D441978
Product name: 3,4-Diethoxycyclobut-3-ene-1,2-dione
Packaging: 500mg
Price: $60
Updated: 2021/12/16

More

Less

Diethyl squarate Chemical Properties,Usage,Production

Chemical Properties

clear yellow to light brownish liquid

Uses

3,4-Dethoxy-3-cyclobutene-1,2-dione is used as a starting material for synthesis of furanones and quinones. It undergoes ethoxy substitution with amines and unsaturated organosilanes.

Uses

Diethyl squarate is an intermediate for pharma products, for photochemicals used in the dry-view process, in synthesis of photosensitive squaraine dyes (eg. laser dyes used in CD-Rom) and as intermediate for functional polymers.

General Description

The reaction of 3,4-diethoxy-3-cyclobutene-1,2-dione (squaric acid diethyl ester) with glycosylamines (formed by reducing oligosaccharides) was studied. The derivatives formed were linked to amino-functionalized lipids, solids or proteins.

Synthesis

64-17-5

2892-51-5

5231-87-8

1. Squaric acid (1.0023 g) was dissolved in 30 mL of anhydrous ethanol and heated to reflux overnight. After the reaction was completed, the reaction solution was concentrated and purified by fast column chromatography to give 0.7430 g of diethyl ester of squaric acid in 50% yield. 2. The resulting diethyl (ethyl) squarate, 2-aminopyridine (100 mg, 0.588 mmol) and triethylamine (10 drops) were dissolved in dichloromethane (10 mL) and stirred at room temperature overnight. After completion of the reaction, the reaction solution was concentrated under reduced pressure and purified by fast column chromatography (petroleum ether/ethyl acetate, 2:1) to afford compound 6 as a white solid in 73% yield. 3. The NMR data of compound 6 were as follows: 1H NMR (400 MHz, acetone-d6) δ 10.26 (s, 1H), 8.50-8.29 (m, 1H), 7.98-7.78 (m, 1H), 7.68 (d, J = 8.3 Hz, 1H), 7.14 (dd, J = 6.9, 5.3 Hz, 1H), 4.85 (q, J = 7.1 Hz, 2H), 1.48 (t, J = 7.1 Hz, 3H); 13C NMR (100 MHz, acetone-d6) δ 186.42, 180.83, 170.33, 166.86, 152.22, 149.33, 139.43, 120.17, 113.63, 70.65, 16.06.

References

[1] Journal of Materials Chemistry A, 2015, vol. 3, # 6, p. 2883 - 2894
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 22, p. 6181 - 6186
[3] Angew. Chem., 2017, vol. 129, # 22, p. 6277 - 6282,6
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 2, p. 263 - 272
[5] Chemical Communications, 2013, vol. 49, # 89, p. 10465 - 10467

Diethyl squarate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Diethyl squarate Suppliers

Americas 1 Belgium 4 China 164 Europe 4 Germany 5 India 5 Japan 3 Switzerland 3 United Kingdom 13 United States 40 Global 242

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Chemexcel (Zhangjiakou) Fine Chemicals Co., Ltd

Tel: 86-10-62944695-809
Fax: 86-10-82415873
Email: sales@chemexcel.com.cn
Country: China
ProdList: 80
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

More

Less

View Lastest Price from Diethyl squarate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Diethyl squarate 5231-87-8
Price: US $2.00-5.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-10

Hebei Chuanghai Biotechnology Co., Ltd

Product: Diethyl squarate 5231-87-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Henan Aochuang Chemical Co.,Ltd.

Product: Diethyl squarate 5231-87-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-19

5231-87-8, Diethyl squarateRelated Search:

Diethyl succinosuccinate Diethyl cyanomethylphosphonate Clethodim Diethyl methylmalonate Methyl acrylate Tris(trimethylsilyl)phosphate Androstenedione DIETHYL PHOSPHATE Diethyl maleate Quinocetone Diethyl ethylmalonate Norandrostenedione Trenbolone Gestodene BUTYL OLEATE Diethyl malonate Diethyl pimelate Squaric acid

3,4-DIETHOXYCYCLOBUTANE-1,2-DIONE

Diethyl squarate, Squaric acid diethyl ester

SQUARIC ACID DIETHYL ESTER,(DIETHYL SQUARATE, 3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE)

DIETHOXYCYCLOBUTENEDIONE

3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE 98%

SQUARICACIDDIETHYLESTER/3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE

3,4-Diethoxy-3-cyclobuten-1,2-dion

Diethyl quadratate

3,4-Diethoxy-3-Cyclobutene-1,2-Dione Diethyl Squarate

3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE, 98 %

DiethylSquarate98%

Diethyl squarate, 1,2-Diethoxy-3,4-dioxocyclobut-1-ene

Diethyl Suquarate Suquaric Acid Diethyl Ester

3,4-Diethoxy-3-cyclobuten-1,2-dione

Diethylsquarate[3,4-Diethoxy-3-cyclobutene-1,2-dione]

DIETHYL SQUARATE

DIETHYL SUQUARATE

3,4-DIETHOXY-3-CYCLOBUTENE-1,2-DIONE

3,4-DIETHOXYCYCLOBUT-3-ENE-1,2-DIONE

1,2-DIETHOXYCYCLOBUTENEDIONE

SQUARIC ACID DIETHYL ESTER

SUQUARIC ACID DIETHYL ESTER

TIMTEC-BB SBB008498

3-Cyclobutene-1,2-dione, 3,4-diethoxy-

SQUARIC ACID DIETHYL ESTER,(DIETHYL SQUARATE, 3,4-DIETHOXY-3-CYCLO

SQUARIC ACID DIETHYL ESTER,(DIETHYL SQUARATE, 3,4-DIETHOXY-

Diethyl squarate in stock Factory

3,4-Diethoxycyclobut-3-ene-1,2-dione 98%

diethoxycyclobut-3-ene-1,2-dione

3,4-Diethoxy-3-cyclobutene-1,2-dione&gt

3,4-DiethoxycycL

obut-3-ene-1,2-dione

TIANFU-CHEM CAS:5231-87-8 Diethyl squarate

5231-87-8

C2H5O2C4O2

Simple 4-Membered Ring Compounds

C7 to C8

Carbonyl Compounds

Building Blocks

Cyclobutanes & Cyclobutenes

Organic Building Blocks

Ketones

Cyclobutanes & Cyclobutenes

Simple 4-Membered Ring Compounds

Ring Systems

Aluminium foil bag/Fluoride bottle or on your request