Bupranolol Property

Melting point:

71-74°C

Boiling point:

396.3±42.0 °C(Predicted)

Density 

1.098±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, Refrigerator, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

13.82±0.20(Predicted)

color 

White to Off-White

Hazard and Precautionary Statements (GHS)

Bupranolol Chemical Properties,Usage,Production

Originator

Betadrenol,Pharma-Schwarz,W. Germany,1969

Uses

Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.

Definition

ChEBI: Bupranolol is an aromatic ether.

Manufacturing Process

A mixture of 16.3 g of (2-chloro-5-methylphenyl)glycidic ether (from epichlorohydrin and 2-chloro-5-methylphenol) and 6.2 g of t-butylamine in 50 ml of ethanol is heated at reflux for 6 hours. The solvent is removed, the residue is washed with water and then extracted with benzene. The dried extract is evaporated to give 1-t-butylamino-3-(2-chloro-5-methylphenoxy)-2- propanol. Treatment of the free base in benzene solution with dry hydrogen chloride yields the hydrochloride salt.

Therapeutic Function

Antiarrhythmic