ChemicalBook > CAS DataBase List > 2-BROMO-5-IODOBENZOIC ACID

2-BROMO-5-IODOBENZOIC ACID

Product Name: 2-BROMO-5-IODOBENZOIC ACID
CAS No.: 25252-00-0
Chemical Name: 2-BROMO-5-IODOBENZOIC ACID
Synonyms: 2-BROMO-5-IODOBENZOIC ACID;Benzoic acid, 2-bromo-5-iodo-;2-Bromo-5-iodobenzoic acid 97%;2-Bromine-5-Iodine Benzoic Acids
CBNumber: CB1114461
Molecular Formula: C7H4BrIO2
Formula Weight: 326.91
MOL File: 25252-00-0.mol

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2-BROMO-5-IODOBENZOIC ACID Property

Melting point:: 171-175 °C
Boiling point:: 371.2±32.0 °C(Predicted)
Density: 2.331±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 2.50±0.10(Predicted)
form: Solid
color: Pale Brown to Brown
Sensitive: Light Sensitive
InChI: InChI=1S/C7H4BrIO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)
InChIKey: QPKKBDSNZFSSOD-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(I)=CC=C1Br
CAS DataBase Reference: 25252-00-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 665339
Product name: 2-Bromo-5-iodobenzoic acid
Purity: 97%
Packaging: 10g
Price: $222.3
Updated: 2025/07/31

TRC

Product number: B687778
Product name: 2-Bromo-5-iodobenzoic acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J91850
Product name: 2-Bromo-5-iodobenzoic acid
Packaging: 25g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR4005
Product name: 2-Bromo-5-iodobenzoic acid
Packaging: 25g
Price: $73
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2621-S-X1
Product name: 2-Bromo-5-iodobenzoic acid
Packaging: 25g
Price: $80
Updated: 2021/12/16

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2-BROMO-5-IODOBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Synthesis

88-65-3

25252-00-0

The general procedure for the synthesis of 2-bromo-5-iodobenzoic acid from o-bromobenzoic acid was as follows: Concentrated sulfuric acid (294.4 g) was added to the reaction flask and the temperature of the reaction system was lowered to 5-10 °C. Subsequently, o-bromobenzoic acid (126.9 g, 0.456 mol) and dichloromethane (687 g) were added. The reaction system was warmed to 15-20 °C and 1,3-diiodo-5,5-dimethyl-acetylurea (total 126.9 g, 0.25 mol, prepared according to Example 1) was added in 4 batches. After 2 hours of reaction at 15-20°C, the reaction solution was slowly poured into ice water (686.9 g) and the reactor temperature was controlled at 15-25°C. Next, 45.8 g ester kettle was added followed by methyl tertiary butyl ether (MTBE, 800 g) and the mixture was stirred for extraction for 20 min. After standing and stratifying, the upper organic phase was separated and collected. The aqueous phase was extracted one more time with MTBE (458 g) and after stirring for 20 min, the layers were separated and the upper organic phase was collected. All the organic phases were combined, kept at 15-25 °C, and treated by adding 5% aqueous sodium sulfite (126.04 g) for 30 min, and after layering, the organic phase was evaporated to dryness at 60 °C under atmospheric pressure. Subsequently, the MTBE in the residue was completely evaporated. Under reduced pressure, toluene (458 g) was added and the temperature of the system was raised to 95 °C to dissolve all substances. It was cooled to 18-22 °C and filtered and the filter cake was washed with toluene. Finally, it was dried at 50-55 °C under vacuum (-0.095 MPa) to give 109.4 g of off-white solid product with ≥98% purity and 73.5% yield.

References

[1] Patent: CN107954861, 2018, A. Location in patent: Paragraph 0094; 0095
[2] Tetrahedron, 2015, vol. 71, # 2, p. 283 - 292

2-BROMO-5-IODOBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-BROMO-5-IODOBENZOIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-BROMO-5-IODOBENZOIC ACID 25252-00-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-BROMO-5-IODOBENZOIC ACID 25252-00-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 2-BROMO-5-IODOBENZOIC ACID 25252-00-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

25252-00-0, 2-BROMO-5-IODOBENZOIC ACIDRelated Search:

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2-BROMO-5-IODOBENZOIC ACID

2-Bromo-5-iodobenzoic acid 97%

2-Bromine-5-Iodine Benzoic Acids

Benzoic acid, 2-bromo-5-iodo-

25252-00-0

C7H4BrIO2

Building Blocks

Carboxylic Acids

Carbonyl Compounds

Organic Building Blocks

Acids & Esters

Bromine Compounds

Iodine Compounds

Carbonyl Compounds

Carboxylic Acids