5-Bromo-2-iodobenzoic acid
- Product Name
- 5-Bromo-2-iodobenzoic acid
- CAS No.
- 21740-00-1
- Chemical Name
- 5-Bromo-2-iodobenzoic acid
- Synonyms
- NSC 190696;RARECHEM AL BO 0892;5-BROMO-2-IODOBENZOIC ACID;5-Bromo-2-iodobenzoicAcid>Benzoic acid, 5-broMo-2-iodo-;5-Bromo-2-iodobenzoic acid 97+%;5-
BroMo- 2- iodobenzoic acid - CBNumber
- CB7222623
- Molecular Formula
- C7H4BrIO2
- Formula Weight
- 326.91
- MOL File
- 21740-00-1.mol
5-Bromo-2-iodobenzoic acid Property
- Melting point:
- 161-163°C
- Boiling point:
- 133-134 °C(Press: 1 Torr)
- Density
- 2.331±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 2.47±0.10(Predicted)
- color
- White to Light yellow
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C7H4BrIO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)
- InChIKey
- IGBNDUKRHPTOBP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Br)=CC=C1I
- CAS DataBase Reference
- 21740-00-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 763462
- Product name
- 5-Bromo-2-iodobenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $82
- Updated
- 2022/05/15
- Product number
- B4296
- Product name
- 5-Bromo-2-iodobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- B687793
- Product name
- 5-Bromo-2-iodobenzoic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B687793
- Product name
- 5-Bromo-2-iodobenzoic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 112100
- Product name
- 5-Bromo-2-iodobenzoic Acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
5-Bromo-2-iodobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
off-white light yellow powder
Uses
It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.
Synthesis
5794-88-7
21740-00-1
General procedure for the synthesis of 5-bromo-2-iodobenzoic acid from 2-amino-5-bromobenzoic acid: a solution of 2-amino-5-bromobenzoic acid (3.9 g, 0.018 mol), sodium nitrite (NaNO2, 1.5 g, 0.022 mol) and sodium hydroxide (NaOH, 0.90 g, 0.023 mmol) in water (55 mL) was added dropwise to a stirred of a concentrated hydrochloric acid solution. The hydrochloric acid (HCl, 6.4 mL) in water (9 mL) solution was cooled at 0°C for 1.5 hours. After dropwise addition, stirring was continued for 30 minutes at 0°C. The formed diazonium salt suspension was added to a stirred solution of potassium iodide (KI, 4.5 g, 0.027 mol) and concentrated hydrochloric acid. A solution of sulfuric acid (H2SO4, 1.1 mL) in water (7.4 mL) was slowly added over 20 minutes at 35 to 40°C. The mixture was then heated to 90 °C and stirred for 30 min. Unreacted iodine was removed by steam distillation. The mixture was stirred and cooled. The crude product was filtered and washed with cold water, then dissolved in 40% aqueous sodium hydroxide. The polymer fraction was separated by decantation and the clarified solution was acidified with concentrated hydrochloric acid. The product was extracted with ether (Et2O). The extract was dried with anhydrous magnesium sulfate (MgSO4) and concentrated in vacuum. The residue was crystallized from a solvent mixture of methanol (MeOH) and water (H2O) (1:1, v/v) to give 5-bromo-2-iodobenzoic acid (3.56 g, 0.0109 mol, 60% yield) as a light yellow solid.
References
[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 46, p. 10851 - 10854
[2] Organic Letters, 2008, vol. 10, # 14, p. 3001 - 3004
[3] Tetrahedron, 2011, vol. 67, # 1, p. 125 - 143
[4] Angewandte Chemie - International Edition, 2012, vol. 51, # 12, p. 2925 - 2929
[5] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
5-Bromo-2-iodobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-iodobenzoic acid manufacturers
- Product
- 5-Bromo-2-iodobenzoic acid 21740-00-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-11
- Product
- 5-Bromo-2-Iodobenzoic Acid 21740-00-1
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- 5-Bromo-2-iodobenzoic acid 21740-00-1
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30