2-BROMO-5-IODOBENZOIC ACID
- Product Name
- 2-BROMO-5-IODOBENZOIC ACID
- CAS No.
- 25252-00-0
- Chemical Name
- 2-BROMO-5-IODOBENZOIC ACID
- Synonyms
- 2-BROMO-5-IODOBENZOIC ACID;Benzoic acid, 2-bromo-5-iodo-;2-Bromo-5-iodobenzoic acid 97%;2-Bromine-5-Iodine Benzoic Acids
- CBNumber
- CB1114461
- Molecular Formula
- C7H4BrIO2
- Formula Weight
- 326.91
- MOL File
- 25252-00-0.mol
2-BROMO-5-IODOBENZOIC ACID Property
- Melting point:
- 171-175 °C
- Boiling point:
- 371.2±32.0 °C(Predicted)
- Density
- 2.331±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 2.50±0.10(Predicted)
- form
- Solid
- color
- Pale Brown to Brown
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C7H4BrIO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)
- InChIKey
- QPKKBDSNZFSSOD-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(I)=CC=C1Br
- CAS DataBase Reference
- 25252-00-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 665339
- Product name
- 2-Bromo-5-iodobenzoic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $222.3
- Updated
- 2025/07/31
- Product number
- B687778
- Product name
- 2-Bromo-5-iodobenzoic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J91850
- Product name
- 2-Bromo-5-iodobenzoic acid
- Packaging
- 25g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR4005
- Product name
- 2-Bromo-5-iodobenzoic acid
- Packaging
- 25g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- 2621-S-X1
- Product name
- 2-Bromo-5-iodobenzoic acid
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
2-BROMO-5-IODOBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Synthesis
88-65-3
25252-00-0
The general procedure for the synthesis of 2-bromo-5-iodobenzoic acid from o-bromobenzoic acid was as follows: Concentrated sulfuric acid (294.4 g) was added to the reaction flask and the temperature of the reaction system was lowered to 5-10 °C. Subsequently, o-bromobenzoic acid (126.9 g, 0.456 mol) and dichloromethane (687 g) were added. The reaction system was warmed to 15-20 °C and 1,3-diiodo-5,5-dimethyl-acetylurea (total 126.9 g, 0.25 mol, prepared according to Example 1) was added in 4 batches. After 2 hours of reaction at 15-20°C, the reaction solution was slowly poured into ice water (686.9 g) and the reactor temperature was controlled at 15-25°C. Next, 45.8 g ester kettle was added followed by methyl tertiary butyl ether (MTBE, 800 g) and the mixture was stirred for extraction for 20 min. After standing and stratifying, the upper organic phase was separated and collected. The aqueous phase was extracted one more time with MTBE (458 g) and after stirring for 20 min, the layers were separated and the upper organic phase was collected. All the organic phases were combined, kept at 15-25 °C, and treated by adding 5% aqueous sodium sulfite (126.04 g) for 30 min, and after layering, the organic phase was evaporated to dryness at 60 °C under atmospheric pressure. Subsequently, the MTBE in the residue was completely evaporated. Under reduced pressure, toluene (458 g) was added and the temperature of the system was raised to 95 °C to dissolve all substances. It was cooled to 18-22 °C and filtered and the filter cake was washed with toluene. Finally, it was dried at 50-55 °C under vacuum (-0.095 MPa) to give 109.4 g of off-white solid product with ≥98% purity and 73.5% yield.
References
[1] Patent: CN107954861, 2018, A. Location in patent: Paragraph 0094; 0095
[2] Tetrahedron, 2015, vol. 71, # 2, p. 283 - 292
2-BROMO-5-IODOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-BROMO-5-IODOBENZOIC ACID Suppliers
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
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View Lastest Price from 2-BROMO-5-IODOBENZOIC ACID manufacturers
- Product
- 2-BROMO-5-IODOBENZOIC ACID 25252-00-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- 2-BROMO-5-IODOBENZOIC ACID 25252-00-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 2-BROMO-5-IODOBENZOIC ACID 25252-00-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08