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Saccharin sodium dihydrate

Product Name
Saccharin sodium dihydrate
CAS No.
6155-57-3
Chemical Name
Saccharin sodium dihydrate
Synonyms
SODIUM SACCHARIN;O-BENZOIC SULFIMIDE SODIUM SALT;2-SULFOBENZOIC AND IMIDE SODIUM SALT DIHYDRATE;SOLUBLE SACCHARIN;Sweetener Sodium Saccharin;SACCHARIN SODIUM SALT DIHYDRATE;O-SULFOBENZIMIDE SODIUM SALT DIHYDRATE;O-BENZOIC SULFIMIDE SODIUM SALT DIHYDRATE;1,1-DIOXIDE-1,2-BENZISOTHIAZOLE-3(2H)-ONE SODIUM SALT, DIHYDRATE;2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE
CBNumber
CB1115998
Molecular Formula
C7H8NNaO4S
Formula Weight
225.19
MOL File
6155-57-3.mol
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Saccharin sodium dihydrate Property

Melting point:
> 300℃
Flash point:
>200°C
storage temp. 
2-8°C
solubility 
1000g/l
form 
powder to crystaline
color 
White to Almost white
PH
6.0-7.5 (100g/l, H2O, 20℃)
Water Solubility 
Soluble in water. Slightly soluble in alcohol
Merck 
14,8311
InChI
InChI=1S/C7H5NO3S.Na.H2O.H/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;;/h1-4H,(H,8,9);;1H2;
InChIKey
BCWVKFPXENUOQA-UHFFFAOYSA-N
SMILES
O=S1(NC(=O)C2C=CC=CC1=2)=O.[NaH].O
CAS DataBase Reference
6155-57-3(CAS DataBase Reference)
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Safety

Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
2
RTECS 
DE4375000
TSCA 
Yes
HS Code 
29350090
Toxicity
LD50 orally in Rabbit: 14200 mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.17042
Product name
Saccharin sodium dihydrate
Purity
EMPROVE? ESSENTIAL, Ph. Eur., USP
Packaging
1KG
Price
$294
Updated
2024/03/01
Sigma-Aldrich
Product number
8.17042
Product name
Saccharin sodium dihydrate
Purity
EMPROVE? ESSENTIAL, Ph. Eur., USP
Packaging
5KG
Price
$733
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14114
Product name
Saccharin sodium salt dihydrate
Purity
for synthesis
Packaging
100G
Price
$36.1
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14114
Product name
Saccharin sodium salt dihydrate
Purity
for synthesis
Packaging
1KG
Price
$151
Updated
2024/03/01
TCI Chemical
Product number
B0131
Product name
o-Sulfobenzimide Sodium Salt Dihydrate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$36
Updated
2024/03/01
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Saccharin sodium dihydrate Chemical Properties,Usage,Production

Description

Saccharin sodium dihydrate is the sodium dihydrate form of saccharin, which belongs to the family of aromatic homomonocyclic compounds. It is an artificial sweetener that is hundreds times as sweet as sucrose. It is mainly used as a food additive to sweeten many products such as drinks, candies, cookies, and medicine. Saccharin is relatively safe for human beings without providing food energy and any nutritional value. It is also safe for diabetes patients to consume.

Chemical Properties

dihydrate granular

Chemical Properties

Saccharin sodium occurs as a white, odorless or faintly aromatic, efflorescent, crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin sodium with other sweeteners. Saccharin sodium can contain variable amounts of water.

Uses

Sweetener (non-nutritive).

Uses

Saccharin Sodium Salt Dihydrate is a non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing.

Production Methods

Saccharin is produced by the oxidation of o-toluene sulfonamide by potassium permanganate in a solution of sodium hydroxide. Acidification of the solution precipitates saccharin, which is then dissolved in water at 50℃ and neutralized by addition of sodium hydroxide. Rapid cooling of the solution initiates crystallization of saccharin sodium from the liquors.

brand name

Sucaryl (Ross).

Pharmaceutical Applications

Saccharin sodium is an intense sweetening agent used in beverages, food products, table-top sweeteners, and pharmaceutical formulations such as tablets, powders, medicated confectionery, gels, suspensions, liquids, and mouthwashes. It is also used in vitamin preparations.
Saccharin sodium is considerably more soluble in water than saccharin, and is more frequently used in pharmaceutical formulations. Its sweetening power is approximately 300–600 times that of sucrose. Saccharin sodium enhances flavor systems and may be used to mask some unpleasant taste characteristics.
Injection of saccharin sodium has been used to measure the armto- tongue circulation time.

Safety

There has been considerable controversy concerning the safety of saccharin and saccharin sodium in recent years; however, it is now generally regarded as a safe, intense sweetener. See Saccharin for further information.
The WHO has set a temporary acceptable daily intake of up to 2.5 mg/kg body-weight for saccharin, including its salts.(3) In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight.
LD50 (mouse, oral): 17.5 g/kg
LD50 (rat, IP): 7.1 g/kg
LD50 (rat, oral): 14.2 g/kg

storage

Saccharin sodium is stable under the normal range of conditions employed in formulations. Only when it is exposed to a high temperature (125℃) at a low pH (pH 2) for over 1 hour does significant decomposition occur. The 84% grade is the most stable form of saccharin sodium since the 76% form will dry further under ambient conditions. Solutions for injection can be sterilized by autoclave.
Saccharin sodium should be stored in a well-closed container in a dry place.

Incompatibilities

Saccharin sodium does not undergo Maillard browning.

Regulatory Status

Accepted for use as a food additive in Europe; ‘E954’ is applied to both saccharin and saccharin salts. Included in the FDA Inactive Ingredients Database (buccal and dental preparations; IM and IV injections; oral and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

References

https://en.wikipedia.org/wiki/Saccharin
https://pubchem.ncbi.nlm.nih.gov/compound/saccharin#section=Top

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Saccharin sodium dihydrate Suppliers

Wuhan yalong new materials co. LTD
Tel
027-86643577 15377507605
Fax
027-86643577
Email
1057540201@qq.com
Country
China
ProdList
136
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58
Wuhan Pinestone Fortune International Trading Co., Ltd.
Tel
27-85615902 13971435335
Email
imp.exp8@fengfan.net
Country
China
ProdList
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58
Wuhan Qingzijing New Materials
Tel
19879292797
Email
603611987@qq.com
Country
China
ProdList
75
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58
Xian Lavia Biotechnology Co., LTD
Tel
18629620162
Email
1600587581@qq.com
Country
China
ProdList
428
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
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Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
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View Lastest Price from Saccharin sodium dihydrate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Saccharin Sodium Dihydrate 6155-57-3
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 ton
Release date
2024-05-09
HebeiShuoshengImportandExportco.,Ltd
Product
Saccharin sodium dihydrate 6155-57-3
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-06
Hebei Weibang Biotechnology Co., Ltd
Product
Saccharin sodium 6155-57-3
Price
US $1.00/PCS
Min. Order
1PCS
Purity
99%
Supply Ability
10mt
Release date
2024-11-01

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