Nemorubicin

ChemicalBook > CAS DataBase List > Nemorubicin

Product Name: Nemorubicin
CAS No.: 108852-90-0
Chemical Name: Nemorubicin
Synonyms: MMRDX;DMM Dox;FCE 23762;PNU 152243;Nemorubicin;PNU-152243A;Nemorubicina;NeMorubincine;-Dichlorobenzophenone;Nemorubicin (PNU 152243)
CBNumber: CB11179292
Molecular Formula: C32H37NO13
Formula Weight: 643.64
MOL File: 108852-90-0.mol

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Nemorubicin Property

Boiling point:: 852.2±65.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);101.0(Max Conc. mM)
pka: 7.35±0.60(Predicted)
form: Powder
color: Orange to reddish brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: N389838
Product name: Nemorubicin
Packaging: 1mg
Price: $615
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024400
Product name: NEMORUBICIN
Purity: 95.00%
Packaging: 1MG
Price: $930.3
Updated: 2021/12/16

Crysdot

Product number: CD31004619
Product name: Nemorubicin
Purity: 98+%
Packaging: 10mg
Price: $977
Updated: 2021/12/16

Crysdot

Product number: CD31004619
Product name: Nemorubicin
Purity: 98+%
Packaging: 5mg
Price: $638
Updated: 2021/12/16

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Nemorubicin Chemical Properties,Usage,Production

Uses

Nemorubicin is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Of note, Nemorubicin is active in cells with upregulation of the nucleotide excision repair (NER) pathway, where current therapies fail. Nemorubicin is biotransformed in the liver into cytotoxic metabolites that may further contribute to render this drug highly active against primary liver tumors or liver metastases.

Definition

ChEBI: Nemorubicin is a member of morpholines, an anthracycline antibiotic, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It is functionally related to a doxorubicin.

in vivo

Nemorubicin is converted to PNU-159682 by human liver cytochrome P450 (CYP) 3A4 in rat, mouse, and dog liver microsomes^[2]. Nemorubicin (60 μg/kg) induces sifnificant tumor growth delay in scid mice bearing 9L/3A4 tumors, but shows no obvious effect on the tumor growth delay of 9L tumors in mice by i.v. or intratumoral injection (i.t.). Nemorubicin (40 μg/kg, i.p.) exhibits no antitumor activity and no host toxicity in mice bearing 9L/3A4 tumors^[4].

target

cancer

Nemorubicin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nemorubicin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Nemorubicin 108852-90-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Nemorubicin 108852-90-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: Nemorubicin 108852-90-0
Price: US $6.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 5kg, 50kg
Release date: 2020-01-09

108852-90-0, NemorubicinRelated Search:

1,8-Dihydroxyanthraquinone Adriamycin Doxorubicinone Nemorubicin Idarubicin Chrysophanic acid 2-Ethyl anthraquinone DIETHANOL PROPANOLAMINE N,N-BIS(2-HYDROXYETHYL)ISOPROPANOLAMINE 1,5-DIHYDROXYANTHRAQUINONE 2,4-DIMETHYL-2'-METHOXYBENZOPHENONE 2,4-DIMETHYL-3'-METHOXYBENZOPHENONE 2,5-DIMETHYL-3'-METHOXYBENZOPHENONE N-ETHYL-TETRAHYDRO-2H-PYRAN-4-AMINE 14-Hydroxy Carminomycin 2-METHOXY-3'-METHYLBENZOPHENONE ISLANDICIN Feudomycin A

Nemorubicin

5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-2,3,6-trideoxy-3-(2S)-2-methoxy-4-morpholinyl-.alpha.-L-lyxo-hexopyranosyloxy-, (8S,10S)-

methoxy-morpholynil-doxorubicin

NeMorubincine

PNU152243A; PNU-152243A; PNU 152243A; NEMORUBICIN; METHOXYMORPHOLINYL-DOXORUBICIN

(1S,3S)-3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 2,3,6-trideoxy-3-[(S)-2-methoxymorpholino]-alpha-L-lyxo-hexopyranoside

DMM Dox

FCE 23762

Methoxymorpholinyldoxorubicin

MMRDX

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranoside

PNU 152243

PNU-152243A

Nemorubicin (PNU 152243)

5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-

5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[(2S)-2-methoxy-4-morpholinyl]-a-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-

FCE 23762,FCE-23762,PNU-152243,PNU152243,inhibit,Methoxymorpholinyl doxorubicin,Inhibitor,Nemorubicin,FCE23762

Nemorubicina

-Dichlorobenzophenone

(8S,10S)-6,8,11-Trihydroxy-10-(((2R,4S,5S,6S)-5-hydroxy-4-((S)-2-methoxymorpholino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

108852-90-0

108852-90-1

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