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Risedronic acid

Product Name
Risedronic acid
CAS No.
105462-24-6
Chemical Name
Risedronic acid
Synonyms
RISEDRONATE;RISEDRONIC ACID;RESEDRONIC ACID;Risedronic Acid RS;Risedronate sodium≥97%;3-(Acetic acid)Pyridine;Risedronic acid (Actonel);RISEDRONIC ACID MONOHYDRATE;Risedronate (Risedronic Acid);Risedronic acid (Risedronate)
CBNumber
CB1118762
Molecular Formula
C7H11NO7P2
Formula Weight
283.11
MOL File
105462-24-6.mol
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Risedronic acid Property

Melting point:
>232°C (subl.)
Boiling point:
692.3±65.0 °C(Predicted)
Density 
1.870±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated)
form 
Solid
pka
1.41±0.10(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKey
IIDJRNMFWXDHID-UHFFFAOYSA-N
SMILES
C(P(=O)(O)O)(P(=O)(O)O)(O)CC1=CC=CN=C1
CAS DataBase Reference
105462-24-6(CAS DataBase Reference)
EPA Substance Registry System
Phosphonic acid, P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis- (105462-24-6)
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Safety

Hazardous Substances Data
105462-24-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Tocris
Product number
3504
Product name
Risedronate
Purity
≥99%(HPLC)
Packaging
50
Price
$90
Updated
2021/12/16
TRC
Product number
R521505
Product name
RisedronicAcid
Packaging
100mg
Price
$130
Updated
2021/12/16
TRC
Product number
R521505
Product name
RisedronicAcid
Packaging
250mg
Price
$180
Updated
2021/12/16
AK Scientific
Product number
J10418
Product name
Risedronicacidmonohydrate
Packaging
100mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
J10418
Product name
Risedronicacidmonohydrate
Packaging
5mg
Price
$19
Updated
2021/12/16
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Risedronic acid Chemical Properties,Usage,Production

Uses

Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor. It is a potentially useful biophosphonate for bone resorption analysis.

Definition

ChEBI: Risedronic acid is a member of pyridines. It is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone.

in vivo

Risedronic acid (Risedronate) (30 μg/kg; subcutaneous injection; once every other day; 3 weeks) prevents radiation-induced osteoporosis in female C57BL/6 mice irradiated with 2 Gy X-rays, inhibits trabecular bone loss and microstructural damage, and suppresses the increase in osteoclast number and serum TRAP5b2.
Risedronic acid (10-25 mg/kg; intraperitoneal injection; once a day; 7 days) inhibits parasitemia in BALB/c mice infected with?Plasmodium berghei?strain ANKA, but does not prolong the survival time of mice3.

Animal Model:Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body2
Dosage:30 μg/kg
Administration:Subcutaneous injection, once every other day, for 3 weeks
Result:Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b.
Animal Model:Male BALB/c mice (3-4 weeks old) infected with?Plasmodium berghei?strain ANKA by intraperitoneal injection of?1×106?blood-stage parasites3
Dosage:10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg
Administration:Intraperitoneal injection, once a day, for 7 days
Result:Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment.

Mode of action

Risedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption.

Risedronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Risedronic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Risedronic acid 105462-24-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
100kg
Release date
2023-01-05
Hebei Chuanghai Biotechnology Co., Ltd
Product
Risedronic acid 105462-24-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Shaanxi Dideu Medichem Co. Ltd
Product
Risedronic Acid 105462-24-6
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-01-16

105462-24-6, Risedronic acidRelated Search:

Amino tris(methylene phosphonic acid) Stearic acid Ethanol Ethylparaben Folic acid Hyaluronic acid 1-Hydroxyethylidene-1,1-diphosphonic acid CHLOROPHOSPHONAZO III ISOXADIFEN-ETHYL Trinexapac-ethyl 2-Ethoxyethanol Ethyl acetate Zoledronic acid Disodium pamidronate Ethyl 2-(Chlorosulfonyl)acetate Citric acid Ascoric Acid Diethyl ether

  • 1-Hydroxy-2-(3-pyridyl)-ethan-1,1-bis-phosphonic acid
  • RISEDRONIC ACID: RISEDRONIC ACID MONOHYDRATE
  • 1-Hydroxy-2-(3-pyridinyl)ethylidenebisphosphonicacidmonohydrate
  • 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE]BISPHOSPHONIC ACID
  • 3-(Acetic acid)Pyridine
  • Risedronic acid(Sodium risedronate intermediate)
  • Phosphonic acid,P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-
  • P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid
  • Risedronic acid (Actonel)
  • (1-Hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid monohydrate
  • RISEDRONIC ACID
  • RISEDRONIC ACID MONOHYDRATE
  • RISEDRONATE
  • RESEDRONIC ACID
  • Risedronate sodium≥97%
  • (1-HYDROXY-1-PHOSPHONO-2-PYRIDIN-3-YL-ETHYL)PHOSPHONIC ACID
  • Risedronic Acid RS
  • Phosphonic acid, [1-hydroxy-2-(3-pyridinyl)ethylidene]bis-
  • (1-Hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid
  • Risedronate (Risedronic Acid)
  • Risedronic acid (Risedronate)
  • TIANFUCHEM--105462-24-6--High purity Risedronic acid factory price
  • 5-(1H-Pyrrol-1-y1)-2- mercaptobenzimidazole
  • 105462-24-6
  • C7H11NO7P2
  • C7H7NO7P2D4
  • API
  • (intermediate of risedronate sodium
  • Risedronate